IgG4-related disease–like fibrosis as an indicator of IgG4-related lymphadenopathy
Abstract The significance of IgG4-related diseases including IgG4-related lymphadenopathy has recently been recognized worldwide. Inflammatory pseudotumors in lymph nodes, as well as in other organs, are also recognized as IgG4-related diseases. Only a few case reports have described IgG4-related ly...
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| Veröffentlicht in: | Annals of diagnostic pathology 2013-10, Vol.17 (5), p.416-420 |
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| creator | Uehara, Takeshi, MD, PhD Masumoto, Junya, MD, PhD Yoshizawa, Akihiko, MD, PhD Kobayashi, Yukihiro, MT, PhD Hamano, Hideaki, MD, PhD Kawa, Shigeyuki, MD, PhD Oki, Keiko, MT Oikawa, Nao, MT Honda, Takayuki, MD, PhD Ota, Hiroyoshi, MD, PhD |
| description | Abstract The significance of IgG4-related diseases including IgG4-related lymphadenopathy has recently been recognized worldwide. Inflammatory pseudotumors in lymph nodes, as well as in other organs, are also recognized as IgG4-related diseases. Only a few case reports have described IgG4-related lymphadenopathy with fibrosis (IgG4-fibrosing lymphadenopathy), and IgG4-fibrosing lymphadenopathy has not been compared clinicopathologically with non–IgG4-related lymphadenopathy with fibrosis. We have evaluated the pathologic features in 13 patients with IgG4-fibrosing lymphadenopathy, including IgG4 and IgG expression in lymph nodes, and compared these features with those of patients with non–IgG4-related lymphadenopathy with fibrosis with reactive inguinal lymphadenopathy and focal fibrosis and lymph nodes at least 10 mm in diameter. IgG4-fibrosing lymphadenopathy was characterized by lymphoplasmacytic and eosinophilic infiltration, many IgG4-positive plasma cells in fibrotic areas, and high serum IgG4 concentrations. The IgG4-positive/IgG-positive plasma cell ratio was significantly higher in the IgG4-fibrosing lymphadenopathy than in the non–IgG4-fibrosing lymphadenopathy group. The presence of even minor fibrosis with characteristics of IgG4-related disease such as IgG4-fibrosing lymphadenopathy may facilitate the diagnosis of IgG4-related lymphadenopathy. |
| doi_str_mv | 10.1016/j.anndiagpath.2013.04.010 |
| format | Article |
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Inflammatory pseudotumors in lymph nodes, as well as in other organs, are also recognized as IgG4-related diseases. Only a few case reports have described IgG4-related lymphadenopathy with fibrosis (IgG4-fibrosing lymphadenopathy), and IgG4-fibrosing lymphadenopathy has not been compared clinicopathologically with non–IgG4-related lymphadenopathy with fibrosis. We have evaluated the pathologic features in 13 patients with IgG4-fibrosing lymphadenopathy, including IgG4 and IgG expression in lymph nodes, and compared these features with those of patients with non–IgG4-related lymphadenopathy with fibrosis with reactive inguinal lymphadenopathy and focal fibrosis and lymph nodes at least 10 mm in diameter. IgG4-fibrosing lymphadenopathy was characterized by lymphoplasmacytic and eosinophilic infiltration, many IgG4-positive plasma cells in fibrotic areas, and high serum IgG4 concentrations. The IgG4-positive/IgG-positive plasma cell ratio was significantly higher in the IgG4-fibrosing lymphadenopathy than in the non–IgG4-fibrosing lymphadenopathy group. The presence of even minor fibrosis with characteristics of IgG4-related disease such as IgG4-fibrosing lymphadenopathy may facilitate the diagnosis of IgG4-related lymphadenopathy.</description><identifier>ISSN: 1092-9134</identifier><identifier>EISSN: 1532-8198</identifier><identifier>DOI: 10.1016/j.anndiagpath.2013.04.010</identifier><identifier>PMID: 23702322</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; Aged, 80 and over ; Female ; Fibrosis - immunology ; Fibrosis - pathology ; Humans ; IgG4-positive plasma cell/IgG-positive plasma cell ratio ; IgG4-related diseases ; IgG4-related lymphadenopathy ; IgG4-related lymphadenopathy with fibrosis ; Immunoglobulin G - immunology ; Immunohistochemistry ; Inflammation - immunology ; Inflammation - pathology ; Lymphatic Diseases - immunology ; Lymphatic Diseases - pathology ; Male ; Middle Aged ; Pathology</subject><ispartof>Annals of diagnostic pathology, 2013-10, Vol.17 (5), p.416-420</ispartof><rights>Elsevier Inc.</rights><rights>2013 Elsevier Inc.</rights><rights>Copyright © 2013 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c432t-a11ed422014d5d0d506ec222d55d5fac3c659f3e1dcc128039ea9da8184ee7213</citedby><cites>FETCH-LOGICAL-c432t-a11ed422014d5d0d506ec222d55d5fac3c659f3e1dcc128039ea9da8184ee7213</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.anndiagpath.2013.04.010$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23702322$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Uehara, Takeshi, MD, PhD</creatorcontrib><creatorcontrib>Masumoto, Junya, MD, PhD</creatorcontrib><creatorcontrib>Yoshizawa, Akihiko, MD, PhD</creatorcontrib><creatorcontrib>Kobayashi, Yukihiro, MT, PhD</creatorcontrib><creatorcontrib>Hamano, Hideaki, MD, PhD</creatorcontrib><creatorcontrib>Kawa, Shigeyuki, MD, PhD</creatorcontrib><creatorcontrib>Oki, Keiko, MT</creatorcontrib><creatorcontrib>Oikawa, Nao, MT</creatorcontrib><creatorcontrib>Honda, Takayuki, MD, PhD</creatorcontrib><creatorcontrib>Ota, Hiroyoshi, MD, PhD</creatorcontrib><title>IgG4-related disease–like fibrosis as an indicator of IgG4-related lymphadenopathy</title><title>Annals of diagnostic pathology</title><addtitle>Ann Diagn Pathol</addtitle><description>Abstract The significance of IgG4-related diseases including IgG4-related lymphadenopathy has recently been recognized worldwide. Inflammatory pseudotumors in lymph nodes, as well as in other organs, are also recognized as IgG4-related diseases. Only a few case reports have described IgG4-related lymphadenopathy with fibrosis (IgG4-fibrosing lymphadenopathy), and IgG4-fibrosing lymphadenopathy has not been compared clinicopathologically with non–IgG4-related lymphadenopathy with fibrosis. We have evaluated the pathologic features in 13 patients with IgG4-fibrosing lymphadenopathy, including IgG4 and IgG expression in lymph nodes, and compared these features with those of patients with non–IgG4-related lymphadenopathy with fibrosis with reactive inguinal lymphadenopathy and focal fibrosis and lymph nodes at least 10 mm in diameter. IgG4-fibrosing lymphadenopathy was characterized by lymphoplasmacytic and eosinophilic infiltration, many IgG4-positive plasma cells in fibrotic areas, and high serum IgG4 concentrations. The IgG4-positive/IgG-positive plasma cell ratio was significantly higher in the IgG4-fibrosing lymphadenopathy than in the non–IgG4-fibrosing lymphadenopathy group. The presence of even minor fibrosis with characteristics of IgG4-related disease such as IgG4-fibrosing lymphadenopathy may facilitate the diagnosis of IgG4-related lymphadenopathy.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Female</subject><subject>Fibrosis - immunology</subject><subject>Fibrosis - pathology</subject><subject>Humans</subject><subject>IgG4-positive plasma cell/IgG-positive plasma cell ratio</subject><subject>IgG4-related diseases</subject><subject>IgG4-related lymphadenopathy</subject><subject>IgG4-related lymphadenopathy with fibrosis</subject><subject>Immunoglobulin G - immunology</subject><subject>Immunohistochemistry</subject><subject>Inflammation - immunology</subject><subject>Inflammation - pathology</subject><subject>Lymphatic Diseases - immunology</subject><subject>Lymphatic Diseases - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pathology</subject><issn>1092-9134</issn><issn>1532-8198</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc9OGzEQxi0EIjTwCmh747LbGf9Jdi-VqqhQpEg9AGfLsWeJk81usDdIufUdeMM-Sb0KVLQnJEvjw_fNN_Mbxj4jFAg4-bIqTNs6bx63pl8WHFAUIAtAOGJnqATPS6zK4_SHiucVCjlin2JcASBKNT1lIy6mwAXnZ-z-9vFG5oEa05PLnI9kIv3-9dL4NWW1X4Qu-piZ9NrMp0xr-i5kXZ3942v2m-3SOGq7YaL9OTupTRPp4rWO2cP19_vZj3z-8-Z29m2eWyl4nxtEcpKn-aVTDpyCCVnOuVPKqdpYYSeqqgWhsxZ5CaIiUzlTYimJphzFmF0d-m5D97Sj2OuNj5aaxrTU7aJGKQSfKpRlklYHqU0bxUC13ga_MWGvEfQAVa_0O6h6gKpB6gQ1eS9fY3aLDbm_zjeKSTA7CCgt--wp6Gg9tZacD2R77Tr_oZiv_3WxjW8T8WZNe4qrbhfaRFOjjlyDvhuuOxwXBQAIMRF_AKlvo6E</recordid><startdate>20131001</startdate><enddate>20131001</enddate><creator>Uehara, Takeshi, MD, PhD</creator><creator>Masumoto, Junya, MD, PhD</creator><creator>Yoshizawa, Akihiko, MD, PhD</creator><creator>Kobayashi, Yukihiro, MT, PhD</creator><creator>Hamano, Hideaki, MD, PhD</creator><creator>Kawa, Shigeyuki, MD, PhD</creator><creator>Oki, Keiko, MT</creator><creator>Oikawa, Nao, MT</creator><creator>Honda, Takayuki, MD, PhD</creator><creator>Ota, Hiroyoshi, MD, PhD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20131001</creationdate><title>IgG4-related disease–like fibrosis as an indicator of IgG4-related lymphadenopathy</title><author>Uehara, Takeshi, MD, PhD ; Masumoto, Junya, MD, PhD ; Yoshizawa, Akihiko, MD, PhD ; Kobayashi, Yukihiro, MT, PhD ; Hamano, Hideaki, MD, PhD ; Kawa, Shigeyuki, MD, PhD ; Oki, Keiko, MT ; Oikawa, Nao, MT ; Honda, Takayuki, MD, PhD ; Ota, Hiroyoshi, MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c432t-a11ed422014d5d0d506ec222d55d5fac3c659f3e1dcc128039ea9da8184ee7213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Female</topic><topic>Fibrosis - immunology</topic><topic>Fibrosis - pathology</topic><topic>Humans</topic><topic>IgG4-positive plasma cell/IgG-positive plasma cell ratio</topic><topic>IgG4-related diseases</topic><topic>IgG4-related lymphadenopathy</topic><topic>IgG4-related lymphadenopathy with fibrosis</topic><topic>Immunoglobulin G - immunology</topic><topic>Immunohistochemistry</topic><topic>Inflammation - immunology</topic><topic>Inflammation - pathology</topic><topic>Lymphatic Diseases - immunology</topic><topic>Lymphatic Diseases - pathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Uehara, Takeshi, MD, PhD</creatorcontrib><creatorcontrib>Masumoto, Junya, MD, PhD</creatorcontrib><creatorcontrib>Yoshizawa, Akihiko, MD, PhD</creatorcontrib><creatorcontrib>Kobayashi, Yukihiro, MT, PhD</creatorcontrib><creatorcontrib>Hamano, Hideaki, MD, PhD</creatorcontrib><creatorcontrib>Kawa, Shigeyuki, MD, PhD</creatorcontrib><creatorcontrib>Oki, Keiko, MT</creatorcontrib><creatorcontrib>Oikawa, Nao, MT</creatorcontrib><creatorcontrib>Honda, Takayuki, MD, PhD</creatorcontrib><creatorcontrib>Ota, Hiroyoshi, MD, PhD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of diagnostic pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Uehara, Takeshi, MD, PhD</au><au>Masumoto, Junya, MD, PhD</au><au>Yoshizawa, Akihiko, MD, PhD</au><au>Kobayashi, Yukihiro, MT, PhD</au><au>Hamano, Hideaki, MD, PhD</au><au>Kawa, Shigeyuki, MD, PhD</au><au>Oki, Keiko, MT</au><au>Oikawa, Nao, MT</au><au>Honda, Takayuki, MD, PhD</au><au>Ota, Hiroyoshi, MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>IgG4-related disease–like fibrosis as an indicator of IgG4-related lymphadenopathy</atitle><jtitle>Annals of diagnostic pathology</jtitle><addtitle>Ann Diagn Pathol</addtitle><date>2013-10-01</date><risdate>2013</risdate><volume>17</volume><issue>5</issue><spage>416</spage><epage>420</epage><pages>416-420</pages><issn>1092-9134</issn><eissn>1532-8198</eissn><abstract>Abstract The significance of IgG4-related diseases including IgG4-related lymphadenopathy has recently been recognized worldwide. Inflammatory pseudotumors in lymph nodes, as well as in other organs, are also recognized as IgG4-related diseases. Only a few case reports have described IgG4-related lymphadenopathy with fibrosis (IgG4-fibrosing lymphadenopathy), and IgG4-fibrosing lymphadenopathy has not been compared clinicopathologically with non–IgG4-related lymphadenopathy with fibrosis. We have evaluated the pathologic features in 13 patients with IgG4-fibrosing lymphadenopathy, including IgG4 and IgG expression in lymph nodes, and compared these features with those of patients with non–IgG4-related lymphadenopathy with fibrosis with reactive inguinal lymphadenopathy and focal fibrosis and lymph nodes at least 10 mm in diameter. IgG4-fibrosing lymphadenopathy was characterized by lymphoplasmacytic and eosinophilic infiltration, many IgG4-positive plasma cells in fibrotic areas, and high serum IgG4 concentrations. The IgG4-positive/IgG-positive plasma cell ratio was significantly higher in the IgG4-fibrosing lymphadenopathy than in the non–IgG4-fibrosing lymphadenopathy group. The presence of even minor fibrosis with characteristics of IgG4-related disease such as IgG4-fibrosing lymphadenopathy may facilitate the diagnosis of IgG4-related lymphadenopathy.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>23702322</pmid><doi>10.1016/j.anndiagpath.2013.04.010</doi><tpages>5</tpages></addata></record> |
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| subjects | Aged Aged, 80 and over Female Fibrosis - immunology Fibrosis - pathology Humans IgG4-positive plasma cell/IgG-positive plasma cell ratio IgG4-related diseases IgG4-related lymphadenopathy IgG4-related lymphadenopathy with fibrosis Immunoglobulin G - immunology Immunohistochemistry Inflammation - immunology Inflammation - pathology Lymphatic Diseases - immunology Lymphatic Diseases - pathology Male Middle Aged Pathology |
| title | IgG4-related disease–like fibrosis as an indicator of IgG4-related lymphadenopathy |
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