LDLR-mediated peptide-22-conjugated nanoparticles for dual-targeting therapy of brain glioma

Abstract Chemotherapy for brain glioma has been of limited benefit due to the inability of drugs to penetrate the blood–brain barrier (BBB) and non-selective drug accumulation in the entire brain. To obviate these limitations, dual-targeting paclitaxel-loaded nanoparticles were developed by decorati...

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Veröffentlicht in:	Biomaterials 2013-12, Vol.34 (36), p.9171-9182
Hauptverfasser:	Zhang, Bo, Sun, Xiyang, Mei, Heng, Wang, Yu, Liao, Ziwei, Chen, Jun, Zhang, Qizhi, Hu, Yu, Pang, Zhiqing, Jiang, Xinguo
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Animals Blood-Brain Barrier - drug effects Blood-Brain Barrier - metabolism Brain glioma Brain Neoplasms - drug therapy Dentistry Drug Delivery Systems Dual targeting Endothelial Cells - drug effects Endothelial Cells - metabolism Fluorescence Glioma - drug therapy In Situ Nick-End Labeling Kaplan-Meier Estimate Low-density lipoprotein receptor Male Mice Mice, Inbred BALB C Mice, Nude Nanoparticles Nanoparticles - chemistry Nanoparticles - ultrastructure Particle Size Peptide-22 Peptides - pharmacology Peptides - therapeutic use Rats Receptors, LDL - metabolism Static Electricity Targeting therapy Tissue Distribution - drug effects
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