Efficacy of bath psoralen plus ultraviolet A (PUVA) vs. system PUVA in psoriasis: a prospective, open, randomized, multicentre study
Summary Background Plaque psoriasis is an inflammatory disease affecting approximately 2% of the population. The clinical hallmarks of psoriasis are sharply demarcated, erythematous plaques with thick scales. Photochemotherapy (psoralen plus ultraviolet A, PUVA) is one of the most effective therapie...
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| Veröffentlicht in: | British journal of dermatology (1951) 2013-09, Vol.169 (3), p.704-708 |
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| container_title | British journal of dermatology (1951) |
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| creator | Berneburg, M. Herzinger, T. Rampf, J. Hoetzenecker, W. Guenova, E. Meisner, C. Maetzke, J. Schaefer, T. Eberlein, B. Scharffetter-Kochanek, K. Rocken, M. |
| description | Summary
Background
Plaque psoriasis is an inflammatory disease affecting approximately 2% of the population. The clinical hallmarks of psoriasis are sharply demarcated, erythematous plaques with thick scales. Photochemotherapy (psoralen plus ultraviolet A, PUVA) is one of the most effective therapies of psoriasis. The photosensitizer 8‐methoxypsoralen (8‐MOP) can be applied either orally (system PUVA) or topically in a warm water bath (bath PUVA).
Objectives
To compare bath PUVA and system PUVA in the treatment of plaque psoriasis.
Methods
This was a randomized, open, prospective, multicentre trial. We included 74 patients with moderate‐to‐severe plaque psoriasis during a 6‐week treatment and a 4‐week follow‐up period. Of the patients enrolled in the study, 38 received bath PUVA and 36 system PUVA.
Results
Both treatment modalities significantly reduced the median Psoriasis Area and Severity Index (PASI) score in the intention‐to‐treat population. Within 6 weeks bath PUVA reduced the median PASI by 74% (16·4 to 4·2) while system PUVA did so by 62% (15·3 to 5·8). The difference between the two modalities was not significant with regard to treatment efficacy (P = 0·389).
Conclusion
There is no difference between bath PUVA and system PUVA in the treatment of psoriasis.
What's already known about this topic?
System photochemotherapy (oral psoralen plus ultraviolet A, system PUVA) is known to be highly effective in psoriasis.
What does this study add?
There was no significant difference between bath PUVA and system PUVA in treating psoriasis in a prospective, randomized, multicentre trial. |
| doi_str_mv | 10.1111/bjd.12466 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1433273613</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1433273613</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4596-35f6de3339b84e1b0b37e90a5cc0a77ba0ad097901f337f710eb83082ed2ed313</originalsourceid><addsrcrecordid>eNp1kc9v0zAUxy0EYqVw4B9AviBtUtPZeUkccytltKAJdmDjaDnOs_DIL-KkEM784bhrN05YlixZn-97zx8T8pKzJQ_rvLgtlzxOsuwRmXHI0ijmAI_JjDEmIiYzOCHPvL9ljANL2VNyEoMQsZRiRv5cWOuMNhNtLS308I12vu11hQ3tqtHTsRp6vXNthQNd0dOr65vVGd35JfWTH7Cm-wvqmruU0975N1TTrm99h2ZwO1zQtsNmQXvdlG3tfmO5oHUo6gw2Q4_UD2M5PSdPrK48vjiec3L9_uLLehtdft58WK8uI5OkMosgtVmJACCLPEFesAIESqZTY5gWotBMl0wKybgFEFZwhkUOLI-xDBs4zMnpoW4Y8MeIflC18warSjfYjl7xBCAWkAV7c3J2QE14i-_Rqq53te4nxZnaS1dBurqTHthXx7JjUWP5QN5bDsDrI6C90ZUNMozz_zghklzme-78wP10FU7_76jefnx33zo6JFz4jV8PCd1_V5kAkaqvnzYqhe3NVbzeqg38BY-yp1A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1433273613</pqid></control><display><type>article</type><title>Efficacy of bath psoralen plus ultraviolet A (PUVA) vs. system PUVA in psoriasis: a prospective, open, randomized, multicentre study</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><source>Oxford University Press Journals All Titles (1996-Current)</source><creator>Berneburg, M. ; Herzinger, T. ; Rampf, J. ; Hoetzenecker, W. ; Guenova, E. ; Meisner, C. ; Maetzke, J. ; Schaefer, T. ; Eberlein, B. ; Scharffetter-Kochanek, K. ; Rocken, M.</creator><creatorcontrib>Berneburg, M. ; Herzinger, T. ; Rampf, J. ; Hoetzenecker, W. ; Guenova, E. ; Meisner, C. ; Maetzke, J. ; Schaefer, T. ; Eberlein, B. ; Scharffetter-Kochanek, K. ; Rocken, M.</creatorcontrib><description>Summary
Background
Plaque psoriasis is an inflammatory disease affecting approximately 2% of the population. The clinical hallmarks of psoriasis are sharply demarcated, erythematous plaques with thick scales. Photochemotherapy (psoralen plus ultraviolet A, PUVA) is one of the most effective therapies of psoriasis. The photosensitizer 8‐methoxypsoralen (8‐MOP) can be applied either orally (system PUVA) or topically in a warm water bath (bath PUVA).
Objectives
To compare bath PUVA and system PUVA in the treatment of plaque psoriasis.
Methods
This was a randomized, open, prospective, multicentre trial. We included 74 patients with moderate‐to‐severe plaque psoriasis during a 6‐week treatment and a 4‐week follow‐up period. Of the patients enrolled in the study, 38 received bath PUVA and 36 system PUVA.
Results
Both treatment modalities significantly reduced the median Psoriasis Area and Severity Index (PASI) score in the intention‐to‐treat population. Within 6 weeks bath PUVA reduced the median PASI by 74% (16·4 to 4·2) while system PUVA did so by 62% (15·3 to 5·8). The difference between the two modalities was not significant with regard to treatment efficacy (P = 0·389).
Conclusion
There is no difference between bath PUVA and system PUVA in the treatment of psoriasis.
What's already known about this topic?
System photochemotherapy (oral psoralen plus ultraviolet A, system PUVA) is known to be highly effective in psoriasis.
What does this study add?
There was no significant difference between bath PUVA and system PUVA in treating psoriasis in a prospective, randomized, multicentre trial.</description><identifier>ISSN: 0007-0963</identifier><identifier>EISSN: 1365-2133</identifier><identifier>DOI: 10.1111/bjd.12466</identifier><identifier>PMID: 23772997</identifier><identifier>CODEN: BJDEAZ</identifier><language>eng</language><publisher>Oxford: Blackwell Publishing Ltd</publisher><subject>Administration, Cutaneous ; Administration, Oral ; Adult ; Aged ; Baths ; Biological and medical sciences ; Dermatology ; Female ; Humans ; Male ; Medical sciences ; Methoxsalen - administration & dosage ; Middle Aged ; Photosensitizing Agents - administration & dosage ; Prospective Studies ; Psoriasis - drug therapy ; Psoriasis. Parapsoriasis. Lichen ; PUVA Therapy - methods ; Treatment Outcome ; Young Adult</subject><ispartof>British journal of dermatology (1951), 2013-09, Vol.169 (3), p.704-708</ispartof><rights>2013 British Association of Dermatologists</rights><rights>2014 INIST-CNRS</rights><rights>2013 British Association of Dermatologists.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4596-35f6de3339b84e1b0b37e90a5cc0a77ba0ad097901f337f710eb83082ed2ed313</citedby><cites>FETCH-LOGICAL-c4596-35f6de3339b84e1b0b37e90a5cc0a77ba0ad097901f337f710eb83082ed2ed313</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fbjd.12466$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fbjd.12466$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27748987$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23772997$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Berneburg, M.</creatorcontrib><creatorcontrib>Herzinger, T.</creatorcontrib><creatorcontrib>Rampf, J.</creatorcontrib><creatorcontrib>Hoetzenecker, W.</creatorcontrib><creatorcontrib>Guenova, E.</creatorcontrib><creatorcontrib>Meisner, C.</creatorcontrib><creatorcontrib>Maetzke, J.</creatorcontrib><creatorcontrib>Schaefer, T.</creatorcontrib><creatorcontrib>Eberlein, B.</creatorcontrib><creatorcontrib>Scharffetter-Kochanek, K.</creatorcontrib><creatorcontrib>Rocken, M.</creatorcontrib><title>Efficacy of bath psoralen plus ultraviolet A (PUVA) vs. system PUVA in psoriasis: a prospective, open, randomized, multicentre study</title><title>British journal of dermatology (1951)</title><addtitle>Br J Dermatol</addtitle><description>Summary
Background
Plaque psoriasis is an inflammatory disease affecting approximately 2% of the population. The clinical hallmarks of psoriasis are sharply demarcated, erythematous plaques with thick scales. Photochemotherapy (psoralen plus ultraviolet A, PUVA) is one of the most effective therapies of psoriasis. The photosensitizer 8‐methoxypsoralen (8‐MOP) can be applied either orally (system PUVA) or topically in a warm water bath (bath PUVA).
Objectives
To compare bath PUVA and system PUVA in the treatment of plaque psoriasis.
Methods
This was a randomized, open, prospective, multicentre trial. We included 74 patients with moderate‐to‐severe plaque psoriasis during a 6‐week treatment and a 4‐week follow‐up period. Of the patients enrolled in the study, 38 received bath PUVA and 36 system PUVA.
Results
Both treatment modalities significantly reduced the median Psoriasis Area and Severity Index (PASI) score in the intention‐to‐treat population. Within 6 weeks bath PUVA reduced the median PASI by 74% (16·4 to 4·2) while system PUVA did so by 62% (15·3 to 5·8). The difference between the two modalities was not significant with regard to treatment efficacy (P = 0·389).
Conclusion
There is no difference between bath PUVA and system PUVA in the treatment of psoriasis.
What's already known about this topic?
System photochemotherapy (oral psoralen plus ultraviolet A, system PUVA) is known to be highly effective in psoriasis.
What does this study add?
There was no significant difference between bath PUVA and system PUVA in treating psoriasis in a prospective, randomized, multicentre trial.</description><subject>Administration, Cutaneous</subject><subject>Administration, Oral</subject><subject>Adult</subject><subject>Aged</subject><subject>Baths</subject><subject>Biological and medical sciences</subject><subject>Dermatology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Methoxsalen - administration & dosage</subject><subject>Middle Aged</subject><subject>Photosensitizing Agents - administration & dosage</subject><subject>Prospective Studies</subject><subject>Psoriasis - drug therapy</subject><subject>Psoriasis. Parapsoriasis. Lichen</subject><subject>PUVA Therapy - methods</subject><subject>Treatment Outcome</subject><subject>Young Adult</subject><issn>0007-0963</issn><issn>1365-2133</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc9v0zAUxy0EYqVw4B9AviBtUtPZeUkccytltKAJdmDjaDnOs_DIL-KkEM784bhrN05YlixZn-97zx8T8pKzJQ_rvLgtlzxOsuwRmXHI0ijmAI_JjDEmIiYzOCHPvL9ljANL2VNyEoMQsZRiRv5cWOuMNhNtLS308I12vu11hQ3tqtHTsRp6vXNthQNd0dOr65vVGd35JfWTH7Cm-wvqmruU0975N1TTrm99h2ZwO1zQtsNmQXvdlG3tfmO5oHUo6gw2Q4_UD2M5PSdPrK48vjiec3L9_uLLehtdft58WK8uI5OkMosgtVmJACCLPEFesAIESqZTY5gWotBMl0wKybgFEFZwhkUOLI-xDBs4zMnpoW4Y8MeIflC18warSjfYjl7xBCAWkAV7c3J2QE14i-_Rqq53te4nxZnaS1dBurqTHthXx7JjUWP5QN5bDsDrI6C90ZUNMozz_zghklzme-78wP10FU7_76jefnx33zo6JFz4jV8PCd1_V5kAkaqvnzYqhe3NVbzeqg38BY-yp1A</recordid><startdate>201309</startdate><enddate>201309</enddate><creator>Berneburg, M.</creator><creator>Herzinger, T.</creator><creator>Rampf, J.</creator><creator>Hoetzenecker, W.</creator><creator>Guenova, E.</creator><creator>Meisner, C.</creator><creator>Maetzke, J.</creator><creator>Schaefer, T.</creator><creator>Eberlein, B.</creator><creator>Scharffetter-Kochanek, K.</creator><creator>Rocken, M.</creator><general>Blackwell Publishing Ltd</general><general>Wiley-Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201309</creationdate><title>Efficacy of bath psoralen plus ultraviolet A (PUVA) vs. system PUVA in psoriasis: a prospective, open, randomized, multicentre study</title><author>Berneburg, M. ; Herzinger, T. ; Rampf, J. ; Hoetzenecker, W. ; Guenova, E. ; Meisner, C. ; Maetzke, J. ; Schaefer, T. ; Eberlein, B. ; Scharffetter-Kochanek, K. ; Rocken, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4596-35f6de3339b84e1b0b37e90a5cc0a77ba0ad097901f337f710eb83082ed2ed313</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Administration, Cutaneous</topic><topic>Administration, Oral</topic><topic>Adult</topic><topic>Aged</topic><topic>Baths</topic><topic>Biological and medical sciences</topic><topic>Dermatology</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Methoxsalen - administration & dosage</topic><topic>Middle Aged</topic><topic>Photosensitizing Agents - administration & dosage</topic><topic>Prospective Studies</topic><topic>Psoriasis - drug therapy</topic><topic>Psoriasis. Parapsoriasis. Lichen</topic><topic>PUVA Therapy - methods</topic><topic>Treatment Outcome</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Berneburg, M.</creatorcontrib><creatorcontrib>Herzinger, T.</creatorcontrib><creatorcontrib>Rampf, J.</creatorcontrib><creatorcontrib>Hoetzenecker, W.</creatorcontrib><creatorcontrib>Guenova, E.</creatorcontrib><creatorcontrib>Meisner, C.</creatorcontrib><creatorcontrib>Maetzke, J.</creatorcontrib><creatorcontrib>Schaefer, T.</creatorcontrib><creatorcontrib>Eberlein, B.</creatorcontrib><creatorcontrib>Scharffetter-Kochanek, K.</creatorcontrib><creatorcontrib>Rocken, M.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of dermatology (1951)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Berneburg, M.</au><au>Herzinger, T.</au><au>Rampf, J.</au><au>Hoetzenecker, W.</au><au>Guenova, E.</au><au>Meisner, C.</au><au>Maetzke, J.</au><au>Schaefer, T.</au><au>Eberlein, B.</au><au>Scharffetter-Kochanek, K.</au><au>Rocken, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficacy of bath psoralen plus ultraviolet A (PUVA) vs. system PUVA in psoriasis: a prospective, open, randomized, multicentre study</atitle><jtitle>British journal of dermatology (1951)</jtitle><addtitle>Br J Dermatol</addtitle><date>2013-09</date><risdate>2013</risdate><volume>169</volume><issue>3</issue><spage>704</spage><epage>708</epage><pages>704-708</pages><issn>0007-0963</issn><eissn>1365-2133</eissn><coden>BJDEAZ</coden><abstract>Summary
Background
Plaque psoriasis is an inflammatory disease affecting approximately 2% of the population. The clinical hallmarks of psoriasis are sharply demarcated, erythematous plaques with thick scales. Photochemotherapy (psoralen plus ultraviolet A, PUVA) is one of the most effective therapies of psoriasis. The photosensitizer 8‐methoxypsoralen (8‐MOP) can be applied either orally (system PUVA) or topically in a warm water bath (bath PUVA).
Objectives
To compare bath PUVA and system PUVA in the treatment of plaque psoriasis.
Methods
This was a randomized, open, prospective, multicentre trial. We included 74 patients with moderate‐to‐severe plaque psoriasis during a 6‐week treatment and a 4‐week follow‐up period. Of the patients enrolled in the study, 38 received bath PUVA and 36 system PUVA.
Results
Both treatment modalities significantly reduced the median Psoriasis Area and Severity Index (PASI) score in the intention‐to‐treat population. Within 6 weeks bath PUVA reduced the median PASI by 74% (16·4 to 4·2) while system PUVA did so by 62% (15·3 to 5·8). The difference between the two modalities was not significant with regard to treatment efficacy (P = 0·389).
Conclusion
There is no difference between bath PUVA and system PUVA in the treatment of psoriasis.
What's already known about this topic?
System photochemotherapy (oral psoralen plus ultraviolet A, system PUVA) is known to be highly effective in psoriasis.
What does this study add?
There was no significant difference between bath PUVA and system PUVA in treating psoriasis in a prospective, randomized, multicentre trial.</abstract><cop>Oxford</cop><pub>Blackwell Publishing Ltd</pub><pmid>23772997</pmid><doi>10.1111/bjd.12466</doi><tpages>5</tpages></addata></record> |
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| ispartof | British journal of dermatology (1951), 2013-09, Vol.169 (3), p.704-708 |
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| source | MEDLINE; Access via Wiley Online Library; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Administration, Cutaneous Administration, Oral Adult Aged Baths Biological and medical sciences Dermatology Female Humans Male Medical sciences Methoxsalen - administration & dosage Middle Aged Photosensitizing Agents - administration & dosage Prospective Studies Psoriasis - drug therapy Psoriasis. Parapsoriasis. Lichen PUVA Therapy - methods Treatment Outcome Young Adult |
| title | Efficacy of bath psoralen plus ultraviolet A (PUVA) vs. system PUVA in psoriasis: a prospective, open, randomized, multicentre study |
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