Capsaicin stimulates glucose uptake in C2C12 muscle cells via the reactive oxygen species (ROS)/AMPK/p38 MAPK pathway

•We provide the molecular mechanism by which capsaicin increases glucose uptake.•Capsaicin increases glucose uptake directly by activating AMPK in C2C12 muscle cells.•Capsaicin treatment generates ROS and subsequently activates AMPK and p38 MAPK.•Glucose uptake by capsaicin is independent of insulin...

Ausführliche Beschreibung