Multi-parameter single-cell kinetic analysis reveals multiple modes of cell death in primary pancreatic β-cells

Programmed β-cell death plays an important role in both type 1 and type 2 diabetes. Most of what is known about the mechanisms of β-cell death comes from single time-point, single parameter measurements of bulk populations of mixed cells. Such approaches are inadequate for determining the true exten...

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Veröffentlicht in:	Journal of cell science 2013-09, Vol.126 (Pt 18), p.4286-4295
Hauptverfasser:	Yang, Yu Hsuan Carol, Johnson, James D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Cell Death Diabetes Mellitus, Type 1 - genetics Diabetes Mellitus, Type 1 - metabolism Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - metabolism Endoplasmic Reticulum Stress Humans Insulin-Secreting Cells - cytology Insulin-Secreting Cells - metabolism Insulin-Secreting Cells - physiology Kinetics Mice Mice, Inbred C57BL
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