Active Crohn's disease is associated with low vitamin D levels
Crohn's disease prevalence increases with increasing latitude. Because most vitamin D comes from sunlight exposure and murine models of intestinal inflammation have demonstrated beneficial effects of 1,25-(OH)2 vitamin D treatment, we hypothesised that Crohn's disease activity is associate...
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| Veröffentlicht in: | Journal of Crohn's and colitis 2013-11, Vol.7 (10), p.e407-e413 |
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| container_title | Journal of Crohn's and colitis |
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| creator | Jørgensen, Søren Peter Hvas, Christian Lodberg Agnholt, Jørgen Christensen, Lisbet Ambrosius Heickendorff, Lene Dahlerup, Jens Frederik |
| description | Crohn's disease prevalence increases with increasing latitude. Because most vitamin D comes from sunlight exposure and murine models of intestinal inflammation have demonstrated beneficial effects of 1,25-(OH)2 vitamin D treatment, we hypothesised that Crohn's disease activity is associated with low vitamin D levels.
In a cross-sectional study of 182 CD patients and 62 healthy controls, we measured serum 25-OH vitamin D. Stratified analysis was used to compare 25-OH vitamin D levels with Crohn's disease activity index, C-reactive protein, smoking status, intake of oral vitamin D supplements and seasonal variation in CD patients and healthy controls.
Serum 25-OH vitamin D was inversely associated with disease activity: Median 25-OH vitamin D levels of Crohn's disease in remission, mildly, and moderately active diseases evaluated by Crohn's disease activity index were 64, 49, and 21nmol/l (p |
| doi_str_mv | 10.1016/j.crohns.2013.01.012 |
| format | Article |
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In a cross-sectional study of 182 CD patients and 62 healthy controls, we measured serum 25-OH vitamin D. Stratified analysis was used to compare 25-OH vitamin D levels with Crohn's disease activity index, C-reactive protein, smoking status, intake of oral vitamin D supplements and seasonal variation in CD patients and healthy controls.
Serum 25-OH vitamin D was inversely associated with disease activity: Median 25-OH vitamin D levels of Crohn's disease in remission, mildly, and moderately active diseases evaluated by Crohn's disease activity index were 64, 49, and 21nmol/l (p<0.01) and by CRP 68, 76, and 35nmol/l (p<0.05), respectively. Patients who took oral vitamin D supplementation had lower Crohn's disease activity index (p<0.05) and C-reactive protein (p=0.07) than non-users. Crohn's disease patients who smoked had lower vitamin D levels (51nmol/l) than patients who did not smoke (76nmol/l), p<0.01. Overall, Crohn's disease patients did not differ from healthy controls regarding 25-OH vitamin D levels.
Active Crohn's disease was associated with low serum 25-OH vitamin D. Patients who smoked had lower 25-OH vitamin D levels than patients who did not smoke, independently of disease activity.</description><identifier>ISSN: 1873-9946</identifier><identifier>EISSN: 1876-4479</identifier><identifier>DOI: 10.1016/j.crohns.2013.01.012</identifier><identifier>PMID: 23403039</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>Adolescent ; Adult ; Aged ; C-Reactive Protein - metabolism ; Case-Control Studies ; Crohn Disease - blood ; Crohn's disease ; Cross-Sectional Studies ; Dietary Supplements ; Female ; Humans ; Male ; Middle Aged ; Seasons ; Severity of Illness Index ; Smoking ; Smoking - blood ; Vitamin D ; Vitamin D - administration & dosage ; Vitamin D - analogs & derivatives ; Vitamin D - blood ; Vitamins - administration & dosage ; Young Adult</subject><ispartof>Journal of Crohn's and colitis, 2013-11, Vol.7 (10), p.e407-e413</ispartof><rights>2013 European Crohn's and Colitis Organisation</rights><rights>Copyright © 2013 European Crohn's and Colitis Organisation. Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c277t-9f9b7fbf2312ca1446379e2f8c41abdb9d90e5040995c6337f7acaa8044727533</citedby><cites>FETCH-LOGICAL-c277t-9f9b7fbf2312ca1446379e2f8c41abdb9d90e5040995c6337f7acaa8044727533</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23403039$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jørgensen, Søren Peter</creatorcontrib><creatorcontrib>Hvas, Christian Lodberg</creatorcontrib><creatorcontrib>Agnholt, Jørgen</creatorcontrib><creatorcontrib>Christensen, Lisbet Ambrosius</creatorcontrib><creatorcontrib>Heickendorff, Lene</creatorcontrib><creatorcontrib>Dahlerup, Jens Frederik</creatorcontrib><title>Active Crohn's disease is associated with low vitamin D levels</title><title>Journal of Crohn's and colitis</title><addtitle>J Crohns Colitis</addtitle><description>Crohn's disease prevalence increases with increasing latitude. Because most vitamin D comes from sunlight exposure and murine models of intestinal inflammation have demonstrated beneficial effects of 1,25-(OH)2 vitamin D treatment, we hypothesised that Crohn's disease activity is associated with low vitamin D levels.
In a cross-sectional study of 182 CD patients and 62 healthy controls, we measured serum 25-OH vitamin D. Stratified analysis was used to compare 25-OH vitamin D levels with Crohn's disease activity index, C-reactive protein, smoking status, intake of oral vitamin D supplements and seasonal variation in CD patients and healthy controls.
Serum 25-OH vitamin D was inversely associated with disease activity: Median 25-OH vitamin D levels of Crohn's disease in remission, mildly, and moderately active diseases evaluated by Crohn's disease activity index were 64, 49, and 21nmol/l (p<0.01) and by CRP 68, 76, and 35nmol/l (p<0.05), respectively. Patients who took oral vitamin D supplementation had lower Crohn's disease activity index (p<0.05) and C-reactive protein (p=0.07) than non-users. Crohn's disease patients who smoked had lower vitamin D levels (51nmol/l) than patients who did not smoke (76nmol/l), p<0.01. Overall, Crohn's disease patients did not differ from healthy controls regarding 25-OH vitamin D levels.
Active Crohn's disease was associated with low serum 25-OH vitamin D. Patients who smoked had lower 25-OH vitamin D levels than patients who did not smoke, independently of disease activity.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>C-Reactive Protein - metabolism</subject><subject>Case-Control Studies</subject><subject>Crohn Disease - blood</subject><subject>Crohn's disease</subject><subject>Cross-Sectional Studies</subject><subject>Dietary Supplements</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Seasons</subject><subject>Severity of Illness Index</subject><subject>Smoking</subject><subject>Smoking - blood</subject><subject>Vitamin D</subject><subject>Vitamin D - administration & dosage</subject><subject>Vitamin D - analogs & derivatives</subject><subject>Vitamin D - blood</subject><subject>Vitamins - administration & dosage</subject><subject>Young Adult</subject><issn>1873-9946</issn><issn>1876-4479</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1Lw0AQxRdRbK3-ByJ700vqfiXbvRRK_YSCFz0vm82Ebkmamklb_O_dmupReDBzeDOP9yPkmrMxZzy7X4192yzXOBaMyzHjUeKEDPlEZ4lS2pz-7DIxRmUDcoG4Yiw1qZ6ck4GQikkmzZBMZ74LO6Dzw69bpEVAcAg0IHWIjQ-ug4LuQ7ekVbOnu9C5OqzpA61gBxVekrPSVQhXxzkiH0-P7_OXZPH2_DqfLRIvtO4SU5pcl3kpJBfecaUyqQ2IcuIVd3mRm8IwSJlixqQ-k1KX2nnnJiwWETqVckTu-r-btvncAna2Duihqtwami1arqQUOtbKolX11ogHsYXSbtpQu_bLcmYP5OzK9uTsgZxlPErEs5tjwjavofg7-kUVDdPeEGvDLkBr0QdYeyhCC76zRRP-T_gGm71_sw</recordid><startdate>20131101</startdate><enddate>20131101</enddate><creator>Jørgensen, Søren Peter</creator><creator>Hvas, Christian Lodberg</creator><creator>Agnholt, Jørgen</creator><creator>Christensen, Lisbet Ambrosius</creator><creator>Heickendorff, Lene</creator><creator>Dahlerup, Jens Frederik</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20131101</creationdate><title>Active Crohn's disease is associated with low vitamin D levels</title><author>Jørgensen, Søren Peter ; Hvas, Christian Lodberg ; Agnholt, Jørgen ; Christensen, Lisbet Ambrosius ; Heickendorff, Lene ; Dahlerup, Jens Frederik</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c277t-9f9b7fbf2312ca1446379e2f8c41abdb9d90e5040995c6337f7acaa8044727533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>C-Reactive Protein - metabolism</topic><topic>Case-Control Studies</topic><topic>Crohn Disease - blood</topic><topic>Crohn's disease</topic><topic>Cross-Sectional Studies</topic><topic>Dietary Supplements</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Seasons</topic><topic>Severity of Illness Index</topic><topic>Smoking</topic><topic>Smoking - blood</topic><topic>Vitamin D</topic><topic>Vitamin D - administration & dosage</topic><topic>Vitamin D - analogs & derivatives</topic><topic>Vitamin D - blood</topic><topic>Vitamins - administration & dosage</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jørgensen, Søren Peter</creatorcontrib><creatorcontrib>Hvas, Christian Lodberg</creatorcontrib><creatorcontrib>Agnholt, Jørgen</creatorcontrib><creatorcontrib>Christensen, Lisbet Ambrosius</creatorcontrib><creatorcontrib>Heickendorff, Lene</creatorcontrib><creatorcontrib>Dahlerup, Jens Frederik</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of Crohn's and colitis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jørgensen, Søren Peter</au><au>Hvas, Christian Lodberg</au><au>Agnholt, Jørgen</au><au>Christensen, Lisbet Ambrosius</au><au>Heickendorff, Lene</au><au>Dahlerup, Jens Frederik</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Active Crohn's disease is associated with low vitamin D levels</atitle><jtitle>Journal of Crohn's and colitis</jtitle><addtitle>J Crohns Colitis</addtitle><date>2013-11-01</date><risdate>2013</risdate><volume>7</volume><issue>10</issue><spage>e407</spage><epage>e413</epage><pages>e407-e413</pages><issn>1873-9946</issn><eissn>1876-4479</eissn><abstract>Crohn's disease prevalence increases with increasing latitude. Because most vitamin D comes from sunlight exposure and murine models of intestinal inflammation have demonstrated beneficial effects of 1,25-(OH)2 vitamin D treatment, we hypothesised that Crohn's disease activity is associated with low vitamin D levels.
In a cross-sectional study of 182 CD patients and 62 healthy controls, we measured serum 25-OH vitamin D. Stratified analysis was used to compare 25-OH vitamin D levels with Crohn's disease activity index, C-reactive protein, smoking status, intake of oral vitamin D supplements and seasonal variation in CD patients and healthy controls.
Serum 25-OH vitamin D was inversely associated with disease activity: Median 25-OH vitamin D levels of Crohn's disease in remission, mildly, and moderately active diseases evaluated by Crohn's disease activity index were 64, 49, and 21nmol/l (p<0.01) and by CRP 68, 76, and 35nmol/l (p<0.05), respectively. Patients who took oral vitamin D supplementation had lower Crohn's disease activity index (p<0.05) and C-reactive protein (p=0.07) than non-users. Crohn's disease patients who smoked had lower vitamin D levels (51nmol/l) than patients who did not smoke (76nmol/l), p<0.01. Overall, Crohn's disease patients did not differ from healthy controls regarding 25-OH vitamin D levels.
Active Crohn's disease was associated with low serum 25-OH vitamin D. Patients who smoked had lower 25-OH vitamin D levels than patients who did not smoke, independently of disease activity.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>23403039</pmid><doi>10.1016/j.crohns.2013.01.012</doi></addata></record> |
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| identifier | ISSN: 1873-9946 |
| ispartof | Journal of Crohn's and colitis, 2013-11, Vol.7 (10), p.e407-e413 |
| issn | 1873-9946 1876-4479 |
| language | eng |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE |
| subjects | Adolescent Adult Aged C-Reactive Protein - metabolism Case-Control Studies Crohn Disease - blood Crohn's disease Cross-Sectional Studies Dietary Supplements Female Humans Male Middle Aged Seasons Severity of Illness Index Smoking Smoking - blood Vitamin D Vitamin D - administration & dosage Vitamin D - analogs & derivatives Vitamin D - blood Vitamins - administration & dosage Young Adult |
| title | Active Crohn's disease is associated with low vitamin D levels |
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