Naegleria fowleri glycoconjugates with residues of α-D-mannose are involved in adherence of trophozoites to mouse nasal mucosa
We analyzed the possible role of glycoconjugates containing α-D-mannose and α-D-glucose residues in adherence of trophozoites to mouse nasal epithelium. Trophozoites incubated with 20 μg of one of three different lectins which preferentially recognized these residues were inoculated intranasally in...
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| Veröffentlicht in: | Parasitology research (1987) 2013-10, Vol.112 (10), p.3615-3625 |
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| creator | Carrasco-Yepez, Maricela Campos-Rodriguez, Rafael Godinez-Victoria, Marycarmen Rodriguez-Monroy, Marco Aurelio Jarillo-Luna, Adriana Bonilla-Lemus, Patricia De Oca, Arturo Contis-Montes Rojas-Hernandez, Saul |
| description | We analyzed the possible role of glycoconjugates containing α-D-mannose and α-D-glucose residues in adherence of trophozoites to mouse nasal epithelium. Trophozoites incubated with 20 μg of one of three different lectins which preferentially recognized these residues were inoculated intranasally in Balb/c mice. Mouse survival was 40 % with Pisum sativum and Canavalia ensiformis and 20 % with Galanthus nivalis amebic pretreatment, compared with 0 % survival for control animals administered trophozoites without pretreatment. Possibly some of the glycoproteins found in Naegleria fowleri represent an adherence factor. Differences in the saccharide sequences of the Naegleria species, even on the same glycoconjugate structure, could explain the different results corresponding to the distinct pretreatments (C. ensiformis, G. nivalis, and P. sativum). We found a higher expression of glycoconjugates recognized by P. sativum in Naegleria lovaniensis than N. fowleri, probably due to the higher number of oligosaccharides containing an α-1,6-linked fucose moiety expressed on the former species. |
| doi_str_mv | 10.1007/s00436-013-3549-2 |
| format | Article |
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Trophozoites incubated with 20 μg of one of three different lectins which preferentially recognized these residues were inoculated intranasally in Balb/c mice. Mouse survival was 40 % with Pisum sativum and Canavalia ensiformis and 20 % with Galanthus nivalis amebic pretreatment, compared with 0 % survival for control animals administered trophozoites without pretreatment. Possibly some of the glycoproteins found in Naegleria fowleri represent an adherence factor. Differences in the saccharide sequences of the Naegleria species, even on the same glycoconjugate structure, could explain the different results corresponding to the distinct pretreatments (C. ensiformis, G. nivalis, and P. sativum). We found a higher expression of glycoconjugates recognized by P. sativum in Naegleria lovaniensis than N. fowleri, probably due to the higher number of oligosaccharides containing an α-1,6-linked fucose moiety expressed on the former species.</description><identifier>ISSN: 0932-0113</identifier><identifier>EISSN: 1432-1955</identifier><identifier>DOI: 10.1007/s00436-013-3549-2</identifier><identifier>PMID: 23922203</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Animals ; Biomedical and Life Sciences ; Biomedicine ; Canavalia ensiformis ; Cell adhesion ; Cell Adhesion - physiology ; Flow Cytometry ; fucose ; Galanthus nivalis ; Glucose ; Glycoconjugates - chemistry ; Glycoconjugates - metabolism ; glycoproteins ; Health aspects ; Immunology ; lectins ; Lectins - chemistry ; Lectins - metabolism ; Male ; Mannose - chemistry ; Medical Microbiology ; Mice ; Mice, Inbred BALB C ; Microbiology ; Naegleria - physiology ; Naegleria fowleri ; nasal mucosa ; Nasal Mucosa - metabolism ; oligosaccharides ; Original Paper ; Physiological aspects ; Pisum sativum ; Protista ; Sporozoa ; trophozoites ; Trophozoites - physiology</subject><ispartof>Parasitology research (1987), 2013-10, Vol.112 (10), p.3615-3625</ispartof><rights>Springer-Verlag Berlin Heidelberg 2013</rights><rights>COPYRIGHT 2013 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c407t-b8f3dc898753f2a64bf268acd8302740cb53040e51e374f9b35f1e3ca2b06b203</citedby><cites>FETCH-LOGICAL-c407t-b8f3dc898753f2a64bf268acd8302740cb53040e51e374f9b35f1e3ca2b06b203</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00436-013-3549-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00436-013-3549-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23922203$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Carrasco-Yepez, Maricela</creatorcontrib><creatorcontrib>Campos-Rodriguez, Rafael</creatorcontrib><creatorcontrib>Godinez-Victoria, Marycarmen</creatorcontrib><creatorcontrib>Rodriguez-Monroy, Marco Aurelio</creatorcontrib><creatorcontrib>Jarillo-Luna, Adriana</creatorcontrib><creatorcontrib>Bonilla-Lemus, Patricia</creatorcontrib><creatorcontrib>De Oca, Arturo Contis-Montes</creatorcontrib><creatorcontrib>Rojas-Hernandez, Saul</creatorcontrib><title>Naegleria fowleri glycoconjugates with residues of α-D-mannose are involved in adherence of trophozoites to mouse nasal mucosa</title><title>Parasitology research (1987)</title><addtitle>Parasitol Res</addtitle><addtitle>Parasitol Res</addtitle><description>We analyzed the possible role of glycoconjugates containing α-D-mannose and α-D-glucose residues in adherence of trophozoites to mouse nasal epithelium. Trophozoites incubated with 20 μg of one of three different lectins which preferentially recognized these residues were inoculated intranasally in Balb/c mice. Mouse survival was 40 % with Pisum sativum and Canavalia ensiformis and 20 % with Galanthus nivalis amebic pretreatment, compared with 0 % survival for control animals administered trophozoites without pretreatment. Possibly some of the glycoproteins found in Naegleria fowleri represent an adherence factor. Differences in the saccharide sequences of the Naegleria species, even on the same glycoconjugate structure, could explain the different results corresponding to the distinct pretreatments (C. ensiformis, G. nivalis, and P. sativum). We found a higher expression of glycoconjugates recognized by P. sativum in Naegleria lovaniensis than N. fowleri, probably due to the higher number of oligosaccharides containing an α-1,6-linked fucose moiety expressed on the former species.</description><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Canavalia ensiformis</subject><subject>Cell adhesion</subject><subject>Cell Adhesion - physiology</subject><subject>Flow Cytometry</subject><subject>fucose</subject><subject>Galanthus nivalis</subject><subject>Glucose</subject><subject>Glycoconjugates - chemistry</subject><subject>Glycoconjugates - metabolism</subject><subject>glycoproteins</subject><subject>Health aspects</subject><subject>Immunology</subject><subject>lectins</subject><subject>Lectins - chemistry</subject><subject>Lectins - metabolism</subject><subject>Male</subject><subject>Mannose - chemistry</subject><subject>Medical Microbiology</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Microbiology</subject><subject>Naegleria - physiology</subject><subject>Naegleria fowleri</subject><subject>nasal mucosa</subject><subject>Nasal Mucosa - metabolism</subject><subject>oligosaccharides</subject><subject>Original Paper</subject><subject>Physiological aspects</subject><subject>Pisum sativum</subject><subject>Protista</subject><subject>Sporozoa</subject><subject>trophozoites</subject><subject>Trophozoites - physiology</subject><issn>0932-0113</issn><issn>1432-1955</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1TAQhS0EopfCA7ABL9mkjH_yt6xaCkgVLKBry3HGub5K7IudtGo3PBMvwjPhKIUl8sLH9vlG4zmEvGZwxgDq9wlAiqoAJgpRyrbgT8iOScEL1pblU7KDNmtgTJyQFykdAFhdSfmcnHDRcs5B7MjPLxqHEaPT1Ia7VdBhvDfBBH9YBj1jondu3tOIyfVLPgVLf_8qLotJex8SUh2ROn8bxlvss6C632NEb3B1zjEc9-EhuLXOHOgUlox4nfRIp8WEpF-SZ1aPCV897qfk5urD94tPxfXXj58vzq8LI6Gei66xojdN29SlsFxXsrO8arTpGwG8lmC6UoAELBmKWtq2E6XN0mjeQdXln56Sd1vdYww_8j9mNblkcBy1x9yUymMTvGZ1vVrPNuugR1TO2zBHbfLqcXJ5Lmhdvj8Xmahk1bQZYBtgYkgpolXH6CYd7xUDtQaltqBUDkqtQSmemTeP_SzdhP0_4m8y2cA3Q8pPfsCoDmGJPs_ov1XfbpDVQekhuqRuvnFgEnL2rGGN-AMx-KkW</recordid><startdate>20131001</startdate><enddate>20131001</enddate><creator>Carrasco-Yepez, Maricela</creator><creator>Campos-Rodriguez, Rafael</creator><creator>Godinez-Victoria, Marycarmen</creator><creator>Rodriguez-Monroy, Marco Aurelio</creator><creator>Jarillo-Luna, Adriana</creator><creator>Bonilla-Lemus, Patricia</creator><creator>De Oca, Arturo Contis-Montes</creator><creator>Rojas-Hernandez, Saul</creator><general>Springer-Verlag</general><general>Springer Berlin Heidelberg</general><general>Springer</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20131001</creationdate><title>Naegleria fowleri glycoconjugates with residues of α-D-mannose are involved in adherence of trophozoites to mouse nasal mucosa</title><author>Carrasco-Yepez, Maricela ; Campos-Rodriguez, Rafael ; Godinez-Victoria, Marycarmen ; Rodriguez-Monroy, Marco Aurelio ; Jarillo-Luna, Adriana ; Bonilla-Lemus, Patricia ; De Oca, Arturo Contis-Montes ; Rojas-Hernandez, Saul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c407t-b8f3dc898753f2a64bf268acd8302740cb53040e51e374f9b35f1e3ca2b06b203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Canavalia ensiformis</topic><topic>Cell adhesion</topic><topic>Cell Adhesion - physiology</topic><topic>Flow Cytometry</topic><topic>fucose</topic><topic>Galanthus nivalis</topic><topic>Glucose</topic><topic>Glycoconjugates - chemistry</topic><topic>Glycoconjugates - metabolism</topic><topic>glycoproteins</topic><topic>Health aspects</topic><topic>Immunology</topic><topic>lectins</topic><topic>Lectins - chemistry</topic><topic>Lectins - metabolism</topic><topic>Male</topic><topic>Mannose - chemistry</topic><topic>Medical Microbiology</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Microbiology</topic><topic>Naegleria - physiology</topic><topic>Naegleria fowleri</topic><topic>nasal mucosa</topic><topic>Nasal Mucosa - metabolism</topic><topic>oligosaccharides</topic><topic>Original Paper</topic><topic>Physiological aspects</topic><topic>Pisum sativum</topic><topic>Protista</topic><topic>Sporozoa</topic><topic>trophozoites</topic><topic>Trophozoites - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Carrasco-Yepez, Maricela</creatorcontrib><creatorcontrib>Campos-Rodriguez, Rafael</creatorcontrib><creatorcontrib>Godinez-Victoria, Marycarmen</creatorcontrib><creatorcontrib>Rodriguez-Monroy, Marco Aurelio</creatorcontrib><creatorcontrib>Jarillo-Luna, Adriana</creatorcontrib><creatorcontrib>Bonilla-Lemus, Patricia</creatorcontrib><creatorcontrib>De Oca, Arturo Contis-Montes</creatorcontrib><creatorcontrib>Rojas-Hernandez, Saul</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Parasitology research (1987)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Carrasco-Yepez, Maricela</au><au>Campos-Rodriguez, Rafael</au><au>Godinez-Victoria, Marycarmen</au><au>Rodriguez-Monroy, Marco Aurelio</au><au>Jarillo-Luna, Adriana</au><au>Bonilla-Lemus, Patricia</au><au>De Oca, Arturo Contis-Montes</au><au>Rojas-Hernandez, Saul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Naegleria fowleri glycoconjugates with residues of α-D-mannose are involved in adherence of trophozoites to mouse nasal mucosa</atitle><jtitle>Parasitology research (1987)</jtitle><stitle>Parasitol Res</stitle><addtitle>Parasitol Res</addtitle><date>2013-10-01</date><risdate>2013</risdate><volume>112</volume><issue>10</issue><spage>3615</spage><epage>3625</epage><pages>3615-3625</pages><issn>0932-0113</issn><eissn>1432-1955</eissn><abstract>We analyzed the possible role of glycoconjugates containing α-D-mannose and α-D-glucose residues in adherence of trophozoites to mouse nasal epithelium. Trophozoites incubated with 20 μg of one of three different lectins which preferentially recognized these residues were inoculated intranasally in Balb/c mice. Mouse survival was 40 % with Pisum sativum and Canavalia ensiformis and 20 % with Galanthus nivalis amebic pretreatment, compared with 0 % survival for control animals administered trophozoites without pretreatment. Possibly some of the glycoproteins found in Naegleria fowleri represent an adherence factor. Differences in the saccharide sequences of the Naegleria species, even on the same glycoconjugate structure, could explain the different results corresponding to the distinct pretreatments (C. ensiformis, G. nivalis, and P. sativum). We found a higher expression of glycoconjugates recognized by P. sativum in Naegleria lovaniensis than N. fowleri, probably due to the higher number of oligosaccharides containing an α-1,6-linked fucose moiety expressed on the former species.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>23922203</pmid><doi>10.1007/s00436-013-3549-2</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0932-0113 |
| ispartof | Parasitology research (1987), 2013-10, Vol.112 (10), p.3615-3625 |
| issn | 0932-0113 1432-1955 |
| language | eng |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Animals Biomedical and Life Sciences Biomedicine Canavalia ensiformis Cell adhesion Cell Adhesion - physiology Flow Cytometry fucose Galanthus nivalis Glucose Glycoconjugates - chemistry Glycoconjugates - metabolism glycoproteins Health aspects Immunology lectins Lectins - chemistry Lectins - metabolism Male Mannose - chemistry Medical Microbiology Mice Mice, Inbred BALB C Microbiology Naegleria - physiology Naegleria fowleri nasal mucosa Nasal Mucosa - metabolism oligosaccharides Original Paper Physiological aspects Pisum sativum Protista Sporozoa trophozoites Trophozoites - physiology |
| title | Naegleria fowleri glycoconjugates with residues of α-D-mannose are involved in adherence of trophozoites to mouse nasal mucosa |
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