Phase I Dose Escalation of Doxorubicin Chemotherapy in Tumor-Bearing Equidae

Background There is no information on the use of doxorubicin in horses with tumors. Objective To determine dose‐limiting toxicosis (DLT) and maximum tolerated dose (MTD) of doxorubicin in tumor‐bearing horses. Animals Seventeen horses with 34 localized or multicentric advanced tumors. Methods Two‐st...

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Veröffentlicht in:	Journal of veterinary internal medicine 2013-09, Vol.27 (5), p.1209-1217
Hauptverfasser:	Théon, A.P., Pusterla, N., Magdesian, K.G., Wilson, W.D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics, Antineoplastic - administration & dosage Antibiotics, Antineoplastic - adverse effects Antibiotics, Antineoplastic - therapeutic use Cancer therapies Cardiotoxicity Chemotherapy Clinical trials Cytotoxicity Dogs Dose-Response Relationship, Drug Doxorubicin - administration & dosage Doxorubicin - adverse effects Doxorubicin - therapeutic use Drug dosages Drug Eruptions - veterinary Equine Female Histamine Horse Diseases - drug therapy Horses Male Neoplasms - drug therapy Neoplasms - veterinary Neutropenia - chemically induced Neutropenia - veterinary Oncology Oncology treatment Tumors Veterinary medicine
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