Multidose pharmacokinetics of orally administered florfenicol in the channel catfish (Ictalurus punctatus)
Plasma disposition of florfenicol in channel catfish was investigated after an oral multidose (10 mg/kg for 10 days) administration in freshwater at water temperatures ranging from 24.7 to 25.9 °C. Florfenicol concentrations in plasma were analyzed by means of liquid chromatography with MS/MS detect...
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| Veröffentlicht in: | Journal of veterinary pharmacology and therapeutics 2013-10, Vol.36 (5), p.502-506 |
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| container_title | Journal of veterinary pharmacology and therapeutics |
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| creator | Gaunt, P. S. Langston, C. Wrzesinski, C. Gao, D. Adams, P. Crouch, L. Sweeney, D. Endris, R. |
| description | Plasma disposition of florfenicol in channel catfish was investigated after an oral multidose (10 mg/kg for 10 days) administration in freshwater at water temperatures ranging from 24.7 to 25.9 °C. Florfenicol concentrations in plasma were analyzed by means of liquid chromatography with MS/MS detection. After the administration of florfenicol, the mean terminal half‐life (t1/2), maximum concentration at steady‐state (Css(max)), time of Css(max) (Tmax), minimal concentration at steady‐state (Css(min)), and Vc/F were 9.0 h, 9.72 μg/mL, 8 h, 2.53 μg/mL, and 0.653 L/kg, respectively. These results suggest that florfenicol administered orally at 10 mg/kg body weight for 10 days could be expected to control catfish bacterial pathogens inhibited in vitro by a minimal inhibitory concentration value of |
| doi_str_mv | 10.1111/j.1365-2885.2012.01426.x |
| format | Article |
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S. ; Langston, C. ; Wrzesinski, C. ; Gao, D. ; Adams, P. ; Crouch, L. ; Sweeney, D. ; Endris, R.</creator><creatorcontrib>Gaunt, P. S. ; Langston, C. ; Wrzesinski, C. ; Gao, D. ; Adams, P. ; Crouch, L. ; Sweeney, D. ; Endris, R.</creatorcontrib><description>Plasma disposition of florfenicol in channel catfish was investigated after an oral multidose (10 mg/kg for 10 days) administration in freshwater at water temperatures ranging from 24.7 to 25.9 °C. Florfenicol concentrations in plasma were analyzed by means of liquid chromatography with MS/MS detection. After the administration of florfenicol, the mean terminal half‐life (t1/2), maximum concentration at steady‐state (Css(max)), time of Css(max) (Tmax), minimal concentration at steady‐state (Css(min)), and Vc/F were 9.0 h, 9.72 μg/mL, 8 h, 2.53 μg/mL, and 0.653 L/kg, respectively. 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S.</creatorcontrib><creatorcontrib>Langston, C.</creatorcontrib><creatorcontrib>Wrzesinski, C.</creatorcontrib><creatorcontrib>Gao, D.</creatorcontrib><creatorcontrib>Adams, P.</creatorcontrib><creatorcontrib>Crouch, L.</creatorcontrib><creatorcontrib>Sweeney, D.</creatorcontrib><creatorcontrib>Endris, R.</creatorcontrib><title>Multidose pharmacokinetics of orally administered florfenicol in the channel catfish (Ictalurus punctatus)</title><title>Journal of veterinary pharmacology and therapeutics</title><addtitle>J. Vet. Pharmacol. Ther</addtitle><description>Plasma disposition of florfenicol in channel catfish was investigated after an oral multidose (10 mg/kg for 10 days) administration in freshwater at water temperatures ranging from 24.7 to 25.9 °C. Florfenicol concentrations in plasma were analyzed by means of liquid chromatography with MS/MS detection. After the administration of florfenicol, the mean terminal half‐life (t1/2), maximum concentration at steady‐state (Css(max)), time of Css(max) (Tmax), minimal concentration at steady‐state (Css(min)), and Vc/F were 9.0 h, 9.72 μg/mL, 8 h, 2.53 μg/mL, and 0.653 L/kg, respectively. These results suggest that florfenicol administered orally at 10 mg/kg body weight for 10 days could be expected to control catfish bacterial pathogens inhibited in vitro by a minimal inhibitory concentration value of <2.5 μg/mL.</description><subject>Administration, Oral</subject><subject>Animals</subject><subject>Anti-Bacterial Agents - administration & dosage</subject><subject>Anti-Bacterial Agents - blood</subject><subject>Anti-Bacterial Agents - pharmacokinetics</subject><subject>Chromatography, High Pressure Liquid - methods</subject><subject>Chromatography, High Pressure Liquid - veterinary</subject><subject>Ictaluridae - blood</subject><subject>Ictaluridae - metabolism</subject><subject>Tandem Mass Spectrometry - methods</subject><subject>Tandem Mass Spectrometry - veterinary</subject><subject>Thiamphenicol - administration & dosage</subject><subject>Thiamphenicol - analogs & derivatives</subject><subject>Thiamphenicol - blood</subject><subject>Thiamphenicol - pharmacokinetics</subject><issn>0140-7783</issn><issn>1365-2885</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1v1DAQhi0EokvLX0A-lkOCP5LYOXBAFZRWLe2h0IqL5bXHWm-deGsnYvffk7DtnvHFo5nnnZEehDAlJZ3ep3VJeVMXTMq6ZISyktCKNeX2FVocBq_RYuqSQgjJj9C7nNeEEC4pfYuO2AQwIsUCra_HMHgbM-DNSqdOm_joexi8yTg6HJMOYYe17Xzv8wAJLHYhJge9NzFg3-NhBdisdN9DwEYPzucVPr0wgw5jGjPejP1UD2P-eILeOB0yvH_-j9HPb1_vzr4XVzfnF2dfrgpTEdEU1NaG2YqZJZe1kM4JyyRQaI3RZKmrqrVARQvUVZXVYFvaUgq1AWO4AKP5MTrd792k-DRCHlTns4EQdA9xzIpWnLOmZpxMqNyjJsWcEzi1Sb7TaacoUbNptVazUDULVbNp9c-02k7RD89XxmUH9hB8UTsBn_fAHx9g99-L1eWv27ma8sU-P3vfHvI6PapGcFGr-x_n6vflw8PtXc3VPf8LxWqe6Q</recordid><startdate>201310</startdate><enddate>201310</enddate><creator>Gaunt, P. S.</creator><creator>Langston, C.</creator><creator>Wrzesinski, C.</creator><creator>Gao, D.</creator><creator>Adams, P.</creator><creator>Crouch, L.</creator><creator>Sweeney, D.</creator><creator>Endris, R.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201310</creationdate><title>Multidose pharmacokinetics of orally administered florfenicol in the channel catfish (Ictalurus punctatus)</title><author>Gaunt, P. S. ; Langston, C. ; Wrzesinski, C. ; Gao, D. ; Adams, P. ; Crouch, L. ; Sweeney, D. ; Endris, R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4076-1d5c2d42cb38578ff7d28e1e9cca0ba449de179e1f44daed91911e5cecc37eca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Administration, Oral</topic><topic>Animals</topic><topic>Anti-Bacterial Agents - administration & dosage</topic><topic>Anti-Bacterial Agents - blood</topic><topic>Anti-Bacterial Agents - pharmacokinetics</topic><topic>Chromatography, High Pressure Liquid - methods</topic><topic>Chromatography, High Pressure Liquid - veterinary</topic><topic>Ictaluridae - blood</topic><topic>Ictaluridae - metabolism</topic><topic>Tandem Mass Spectrometry - methods</topic><topic>Tandem Mass Spectrometry - veterinary</topic><topic>Thiamphenicol - administration & dosage</topic><topic>Thiamphenicol - analogs & derivatives</topic><topic>Thiamphenicol - blood</topic><topic>Thiamphenicol - pharmacokinetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gaunt, P. S.</creatorcontrib><creatorcontrib>Langston, C.</creatorcontrib><creatorcontrib>Wrzesinski, C.</creatorcontrib><creatorcontrib>Gao, D.</creatorcontrib><creatorcontrib>Adams, P.</creatorcontrib><creatorcontrib>Crouch, L.</creatorcontrib><creatorcontrib>Sweeney, D.</creatorcontrib><creatorcontrib>Endris, R.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of veterinary pharmacology and therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gaunt, P. S.</au><au>Langston, C.</au><au>Wrzesinski, C.</au><au>Gao, D.</au><au>Adams, P.</au><au>Crouch, L.</au><au>Sweeney, D.</au><au>Endris, R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multidose pharmacokinetics of orally administered florfenicol in the channel catfish (Ictalurus punctatus)</atitle><jtitle>Journal of veterinary pharmacology and therapeutics</jtitle><addtitle>J. Vet. Pharmacol. Ther</addtitle><date>2013-10</date><risdate>2013</risdate><volume>36</volume><issue>5</issue><spage>502</spage><epage>506</epage><pages>502-506</pages><issn>0140-7783</issn><eissn>1365-2885</eissn><abstract>Plasma disposition of florfenicol in channel catfish was investigated after an oral multidose (10 mg/kg for 10 days) administration in freshwater at water temperatures ranging from 24.7 to 25.9 °C. Florfenicol concentrations in plasma were analyzed by means of liquid chromatography with MS/MS detection. After the administration of florfenicol, the mean terminal half‐life (t1/2), maximum concentration at steady‐state (Css(max)), time of Css(max) (Tmax), minimal concentration at steady‐state (Css(min)), and Vc/F were 9.0 h, 9.72 μg/mL, 8 h, 2.53 μg/mL, and 0.653 L/kg, respectively. These results suggest that florfenicol administered orally at 10 mg/kg body weight for 10 days could be expected to control catfish bacterial pathogens inhibited in vitro by a minimal inhibitory concentration value of <2.5 μg/mL.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>22882087</pmid><doi>10.1111/j.1365-2885.2012.01426.x</doi><tpages>5</tpages></addata></record> |
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| ispartof | Journal of veterinary pharmacology and therapeutics, 2013-10, Vol.36 (5), p.502-506 |
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| language | eng |
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| subjects | Administration, Oral Animals Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - blood Anti-Bacterial Agents - pharmacokinetics Chromatography, High Pressure Liquid - methods Chromatography, High Pressure Liquid - veterinary Ictaluridae - blood Ictaluridae - metabolism Tandem Mass Spectrometry - methods Tandem Mass Spectrometry - veterinary Thiamphenicol - administration & dosage Thiamphenicol - analogs & derivatives Thiamphenicol - blood Thiamphenicol - pharmacokinetics |
| title | Multidose pharmacokinetics of orally administered florfenicol in the channel catfish (Ictalurus punctatus) |
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