Interactions between toluene and alcohol
Weanling male Fischer-344 rats were exposed by inhalation to air or 2000 ppm toluene for 8 hours each day for 2 weeks. Subgroups had access to water or 6% alcohol as their only fluid sources, respectively. Rats exposed to both toluene and alcohol subsequently showed a marked preference for 6% alcoho...
Gespeichert in:
| Veröffentlicht in: | Pharmacology, biochemistry and behavior biochemistry and behavior, 1985-01, Vol.23 (3), p.401-410 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 410 |
|---|---|
| container_issue | 3 |
| container_start_page | 401 |
| container_title | Pharmacology, biochemistry and behavior |
| container_volume | 23 |
| creator | Pryor, Gordon T. Howd, Robert A. Uyeno, Edward T. Thurber, Andrea B. |
| description | Weanling male Fischer-344 rats were exposed by inhalation to air or 2000 ppm toluene for 8 hours each day for 2 weeks. Subgroups had access to water or 6% alcohol as their only fluid sources, respectively. Rats exposed to both toluene and alcohol subsequently showed a marked preference for 6% alcohol in two-bottle choice tests that persisted for up to 20 days for some rats. Rats exposed to toluene without access to alcohol and control rats (exposed to air and water) showed a marked aversion to the alcohol solution, and only 2 of 12 rats forced to drink alcohol without exposure to toluene preferred alcohol in the preference tests. Exposure to both toluene and alcohol also caused greater inhibition of weight gain than exposure to either substance alone, accompanied by greater signs of organ toxicity as indicated by clinical blood chemistries. Exposure to toluene caused marked hearing loss as assessed by a behavioral technique (conditioned avoidance), and there was a trend toward enhancement of this ototoxic effect by forced consumption of alcohol. |
| doi_str_mv | 10.1016/0091-3057(85)90013-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_14329656</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0091305785900139</els_id><sourcerecordid>14329656</sourcerecordid><originalsourceid>FETCH-LOGICAL-c417t-2b5f86c8359bb1a54ea9458a9313dee54d158388780eb75a14e9f321a6f3ba33</originalsourceid><addsrcrecordid>eNp9kE9LAzEUxIMotVa_gcIeROphNdkkm-QiSPFPoeCl95DNvsXINqnJruK3d2uXHj29w_xmeDMIXRJ8RzAp7zFWJKeYi7nktwpjQnN1hKZECppzIsQxmh6QU3SW0gfGmBWlmKAJw0wWlE_RfOk7iMZ2LviUVdB9A_isC20PHjLj68y0NryH9hydNKZNcDHeGVo_P60Xr_nq7WW5eFzllhHR5UXFG1laSbmqKmI4A6MYl0ZRQmsAzmrCJZVSSAyV4IYwUA0tiCkbWhlKZ-hmH7uN4bOH1OmNSxba1ngIfdKE0UKVvBxAtgdtDClFaPQ2uo2JP5pgvdtH78rrXXktuf7bR6vBdjXm99UG6oNpHGTQr0fdJGvaJhpvXTpgkpccq2LAHvYYDFN8OYg6WQfeQu0i2E7Xwf3_xy9MrX9G</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>14329656</pqid></control><display><type>article</type><title>Interactions between toluene and alcohol</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Pryor, Gordon T. ; Howd, Robert A. ; Uyeno, Edward T. ; Thurber, Andrea B.</creator><creatorcontrib>Pryor, Gordon T. ; Howd, Robert A. ; Uyeno, Edward T. ; Thurber, Andrea B.</creatorcontrib><description>Weanling male Fischer-344 rats were exposed by inhalation to air or 2000 ppm toluene for 8 hours each day for 2 weeks. Subgroups had access to water or 6% alcohol as their only fluid sources, respectively. Rats exposed to both toluene and alcohol subsequently showed a marked preference for 6% alcohol in two-bottle choice tests that persisted for up to 20 days for some rats. Rats exposed to toluene without access to alcohol and control rats (exposed to air and water) showed a marked aversion to the alcohol solution, and only 2 of 12 rats forced to drink alcohol without exposure to toluene preferred alcohol in the preference tests. Exposure to both toluene and alcohol also caused greater inhibition of weight gain than exposure to either substance alone, accompanied by greater signs of organ toxicity as indicated by clinical blood chemistries. Exposure to toluene caused marked hearing loss as assessed by a behavioral technique (conditioned avoidance), and there was a trend toward enhancement of this ototoxic effect by forced consumption of alcohol.</description><identifier>ISSN: 0091-3057</identifier><identifier>EISSN: 1873-5177</identifier><identifier>DOI: 10.1016/0091-3057(85)90013-9</identifier><identifier>PMID: 4048235</identifier><identifier>CODEN: PBBHAU</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Alcohol Drinking ; Animals ; Behavioral audiometry ; Biological and medical sciences ; Blood Chemical Analysis ; Body Weight - drug effects ; Chemical and industrial products toxicology. Toxic occupational diseases ; Choice Behavior - drug effects ; Clinical blood chemistry ; Conditioning, Operant - drug effects ; Drinking - drug effects ; Drug Interactions ; Enhanced alcohol preference ; Ethanol - blood ; Ethanol - toxicity ; Hearing Disorders - chemically induced ; Male ; Medical sciences ; Rats ; Rats, Inbred F344 ; Solvent abuse Toluene/alcohol interactions ; Solvents ; Substance-Related Disorders ; Time Factors ; Toluene - toxicity ; Toluene-induced hearing loss ; Toxicology</subject><ispartof>Pharmacology, biochemistry and behavior, 1985-01, Vol.23 (3), p.401-410</ispartof><rights>1985</rights><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-2b5f86c8359bb1a54ea9458a9313dee54d158388780eb75a14e9f321a6f3ba33</citedby><cites>FETCH-LOGICAL-c417t-2b5f86c8359bb1a54ea9458a9313dee54d158388780eb75a14e9f321a6f3ba33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0091-3057(85)90013-9$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8565092$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4048235$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pryor, Gordon T.</creatorcontrib><creatorcontrib>Howd, Robert A.</creatorcontrib><creatorcontrib>Uyeno, Edward T.</creatorcontrib><creatorcontrib>Thurber, Andrea B.</creatorcontrib><title>Interactions between toluene and alcohol</title><title>Pharmacology, biochemistry and behavior</title><addtitle>Pharmacol Biochem Behav</addtitle><description>Weanling male Fischer-344 rats were exposed by inhalation to air or 2000 ppm toluene for 8 hours each day for 2 weeks. Subgroups had access to water or 6% alcohol as their only fluid sources, respectively. Rats exposed to both toluene and alcohol subsequently showed a marked preference for 6% alcohol in two-bottle choice tests that persisted for up to 20 days for some rats. Rats exposed to toluene without access to alcohol and control rats (exposed to air and water) showed a marked aversion to the alcohol solution, and only 2 of 12 rats forced to drink alcohol without exposure to toluene preferred alcohol in the preference tests. Exposure to both toluene and alcohol also caused greater inhibition of weight gain than exposure to either substance alone, accompanied by greater signs of organ toxicity as indicated by clinical blood chemistries. Exposure to toluene caused marked hearing loss as assessed by a behavioral technique (conditioned avoidance), and there was a trend toward enhancement of this ototoxic effect by forced consumption of alcohol.</description><subject>Alcohol Drinking</subject><subject>Animals</subject><subject>Behavioral audiometry</subject><subject>Biological and medical sciences</subject><subject>Blood Chemical Analysis</subject><subject>Body Weight - drug effects</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Choice Behavior - drug effects</subject><subject>Clinical blood chemistry</subject><subject>Conditioning, Operant - drug effects</subject><subject>Drinking - drug effects</subject><subject>Drug Interactions</subject><subject>Enhanced alcohol preference</subject><subject>Ethanol - blood</subject><subject>Ethanol - toxicity</subject><subject>Hearing Disorders - chemically induced</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Rats</subject><subject>Rats, Inbred F344</subject><subject>Solvent abuse Toluene/alcohol interactions</subject><subject>Solvents</subject><subject>Substance-Related Disorders</subject><subject>Time Factors</subject><subject>Toluene - toxicity</subject><subject>Toluene-induced hearing loss</subject><subject>Toxicology</subject><issn>0091-3057</issn><issn>1873-5177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9LAzEUxIMotVa_gcIeROphNdkkm-QiSPFPoeCl95DNvsXINqnJruK3d2uXHj29w_xmeDMIXRJ8RzAp7zFWJKeYi7nktwpjQnN1hKZECppzIsQxmh6QU3SW0gfGmBWlmKAJw0wWlE_RfOk7iMZ2LviUVdB9A_isC20PHjLj68y0NryH9hydNKZNcDHeGVo_P60Xr_nq7WW5eFzllhHR5UXFG1laSbmqKmI4A6MYl0ZRQmsAzmrCJZVSSAyV4IYwUA0tiCkbWhlKZ-hmH7uN4bOH1OmNSxba1ngIfdKE0UKVvBxAtgdtDClFaPQ2uo2JP5pgvdtH78rrXXktuf7bR6vBdjXm99UG6oNpHGTQr0fdJGvaJhpvXTpgkpccq2LAHvYYDFN8OYg6WQfeQu0i2E7Xwf3_xy9MrX9G</recordid><startdate>19850101</startdate><enddate>19850101</enddate><creator>Pryor, Gordon T.</creator><creator>Howd, Robert A.</creator><creator>Uyeno, Edward T.</creator><creator>Thurber, Andrea B.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19850101</creationdate><title>Interactions between toluene and alcohol</title><author>Pryor, Gordon T. ; Howd, Robert A. ; Uyeno, Edward T. ; Thurber, Andrea B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-2b5f86c8359bb1a54ea9458a9313dee54d158388780eb75a14e9f321a6f3ba33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Alcohol Drinking</topic><topic>Animals</topic><topic>Behavioral audiometry</topic><topic>Biological and medical sciences</topic><topic>Blood Chemical Analysis</topic><topic>Body Weight - drug effects</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>Choice Behavior - drug effects</topic><topic>Clinical blood chemistry</topic><topic>Conditioning, Operant - drug effects</topic><topic>Drinking - drug effects</topic><topic>Drug Interactions</topic><topic>Enhanced alcohol preference</topic><topic>Ethanol - blood</topic><topic>Ethanol - toxicity</topic><topic>Hearing Disorders - chemically induced</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Rats</topic><topic>Rats, Inbred F344</topic><topic>Solvent abuse Toluene/alcohol interactions</topic><topic>Solvents</topic><topic>Substance-Related Disorders</topic><topic>Time Factors</topic><topic>Toluene - toxicity</topic><topic>Toluene-induced hearing loss</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pryor, Gordon T.</creatorcontrib><creatorcontrib>Howd, Robert A.</creatorcontrib><creatorcontrib>Uyeno, Edward T.</creatorcontrib><creatorcontrib>Thurber, Andrea B.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Pharmacology, biochemistry and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pryor, Gordon T.</au><au>Howd, Robert A.</au><au>Uyeno, Edward T.</au><au>Thurber, Andrea B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interactions between toluene and alcohol</atitle><jtitle>Pharmacology, biochemistry and behavior</jtitle><addtitle>Pharmacol Biochem Behav</addtitle><date>1985-01-01</date><risdate>1985</risdate><volume>23</volume><issue>3</issue><spage>401</spage><epage>410</epage><pages>401-410</pages><issn>0091-3057</issn><eissn>1873-5177</eissn><coden>PBBHAU</coden><abstract>Weanling male Fischer-344 rats were exposed by inhalation to air or 2000 ppm toluene for 8 hours each day for 2 weeks. Subgroups had access to water or 6% alcohol as their only fluid sources, respectively. Rats exposed to both toluene and alcohol subsequently showed a marked preference for 6% alcohol in two-bottle choice tests that persisted for up to 20 days for some rats. Rats exposed to toluene without access to alcohol and control rats (exposed to air and water) showed a marked aversion to the alcohol solution, and only 2 of 12 rats forced to drink alcohol without exposure to toluene preferred alcohol in the preference tests. Exposure to both toluene and alcohol also caused greater inhibition of weight gain than exposure to either substance alone, accompanied by greater signs of organ toxicity as indicated by clinical blood chemistries. Exposure to toluene caused marked hearing loss as assessed by a behavioral technique (conditioned avoidance), and there was a trend toward enhancement of this ototoxic effect by forced consumption of alcohol.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>4048235</pmid><doi>10.1016/0091-3057(85)90013-9</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0091-3057 |
| ispartof | Pharmacology, biochemistry and behavior, 1985-01, Vol.23 (3), p.401-410 |
| issn | 0091-3057 1873-5177 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_14329656 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Alcohol Drinking Animals Behavioral audiometry Biological and medical sciences Blood Chemical Analysis Body Weight - drug effects Chemical and industrial products toxicology. Toxic occupational diseases Choice Behavior - drug effects Clinical blood chemistry Conditioning, Operant - drug effects Drinking - drug effects Drug Interactions Enhanced alcohol preference Ethanol - blood Ethanol - toxicity Hearing Disorders - chemically induced Male Medical sciences Rats Rats, Inbred F344 Solvent abuse Toluene/alcohol interactions Solvents Substance-Related Disorders Time Factors Toluene - toxicity Toluene-induced hearing loss Toxicology |
| title | Interactions between toluene and alcohol |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-21T14%3A46%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Interactions%20between%20toluene%20and%20alcohol&rft.jtitle=Pharmacology,%20biochemistry%20and%20behavior&rft.au=Pryor,%20Gordon%20T.&rft.date=1985-01-01&rft.volume=23&rft.issue=3&rft.spage=401&rft.epage=410&rft.pages=401-410&rft.issn=0091-3057&rft.eissn=1873-5177&rft.coden=PBBHAU&rft_id=info:doi/10.1016/0091-3057(85)90013-9&rft_dat=%3Cproquest_cross%3E14329656%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=14329656&rft_id=info:pmid/4048235&rft_els_id=0091305785900139&rfr_iscdi=true |