Developmental toxicity of OTTO fuel II in the rat and rabbit

OTTO Fuel II (OFII) is a propellent used by the United States Navy in its Mk 46 and Mk 48 torpedoes. Owing to the possibility of human exposure during fueling and defueling operations, studies were initiated to determine if OFII was a developmental toxin. Phase I of the investigation involved dosing...

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Veröffentlicht in:Journal of applied toxicology 1993-07, Vol.13 (4), p.235-239
Hauptverfasser: Cooper, James R., Lee, Lanfong H., Macys, David A.
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Lee, Lanfong H.
Macys, David A.
description OTTO Fuel II (OFII) is a propellent used by the United States Navy in its Mk 46 and Mk 48 torpedoes. Owing to the possibility of human exposure during fueling and defueling operations, studies were initiated to determine if OFII was a developmental toxin. Phase I of the investigation involved dosing four groups of time‐mated Fischer‐344 rats with OFII. The fuel was administered dermally at the rate of 0, 400, 2000 and 4000 mg kg−1 day−1. A significant reduction in body weight was seen at necropsy in dams receiving 2000 and 4000 mg kg−1 day−1 of OFII. Fetuses from these dams also weighed significantly less than control fetuses. Phase II of the investigation involved dosing of artificially inseminated rabbits with OFII. The fuel was administered to the skin of the animal's back at the rate of 0, 100, 316 and 1000 mg kg−1 day−1. Maternal toxicity was evidenced by a significant reduction in body weight of the dams in the 1000 mg kg−1 day−1 dose group on days 20 and 25 of gestation. There were no significant differences observed in maternal weight or fetal weight at necropsy. Morphological examination of both rat and rabbit fetuses failed to reveal significant evidence of fetal malformations.
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Owing to the possibility of human exposure during fueling and defueling operations, studies were initiated to determine if OFII was a developmental toxin. Phase I of the investigation involved dosing four groups of time‐mated Fischer‐344 rats with OFII. The fuel was administered dermally at the rate of 0, 400, 2000 and 4000 mg kg−1 day−1. A significant reduction in body weight was seen at necropsy in dams receiving 2000 and 4000 mg kg−1 day−1 of OFII. Fetuses from these dams also weighed significantly less than control fetuses. Phase II of the investigation involved dosing of artificially inseminated rabbits with OFII. The fuel was administered to the skin of the animal's back at the rate of 0, 100, 316 and 1000 mg kg−1 day−1. Maternal toxicity was evidenced by a significant reduction in body weight of the dams in the 1000 mg kg−1 day−1 dose group on days 20 and 25 of gestation. There were no significant differences observed in maternal weight or fetal weight at necropsy. Morphological examination of both rat and rabbit fetuses failed to reveal significant evidence of fetal malformations.</description><identifier>ISSN: 0260-437X</identifier><identifier>EISSN: 1099-1263</identifier><identifier>DOI: 10.1002/jat.2550130405</identifier><identifier>PMID: 8376723</identifier><identifier>CODEN: JJATDK</identifier><language>eng</language><publisher>Chichester: John Wiley &amp; Sons, Ltd</publisher><subject>Animals ; Biological and medical sciences ; Body Weight - drug effects ; Embryology: invertebrates and vertebrates. Teratology ; Embryonic and Fetal Development - drug effects ; Erythema - chemically induced ; Female ; Fundamental and applied biological sciences. Psychology ; OTTO Fuel II ; Pregnancy ; propylene glycol dinitrate (PGDN) ; Propylene Glycols - toxicity ; rabbit ; Rabbits ; rat ; Rats ; Rats, Inbred F344 ; teratology ; Teratology. 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Appl. Toxicol</addtitle><description>OTTO Fuel II (OFII) is a propellent used by the United States Navy in its Mk 46 and Mk 48 torpedoes. Owing to the possibility of human exposure during fueling and defueling operations, studies were initiated to determine if OFII was a developmental toxin. Phase I of the investigation involved dosing four groups of time‐mated Fischer‐344 rats with OFII. The fuel was administered dermally at the rate of 0, 400, 2000 and 4000 mg kg−1 day−1. A significant reduction in body weight was seen at necropsy in dams receiving 2000 and 4000 mg kg−1 day−1 of OFII. Fetuses from these dams also weighed significantly less than control fetuses. Phase II of the investigation involved dosing of artificially inseminated rabbits with OFII. The fuel was administered to the skin of the animal's back at the rate of 0, 100, 316 and 1000 mg kg−1 day−1. Maternal toxicity was evidenced by a significant reduction in body weight of the dams in the 1000 mg kg−1 day−1 dose group on days 20 and 25 of gestation. There were no significant differences observed in maternal weight or fetal weight at necropsy. Morphological examination of both rat and rabbit fetuses failed to reveal significant evidence of fetal malformations.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Body Weight - drug effects</subject><subject>Embryology: invertebrates and vertebrates. Teratology</subject><subject>Embryonic and Fetal Development - drug effects</subject><subject>Erythema - chemically induced</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>OTTO Fuel II</subject><subject>Pregnancy</subject><subject>propylene glycol dinitrate (PGDN)</subject><subject>Propylene Glycols - toxicity</subject><subject>rabbit</subject><subject>Rabbits</subject><subject>rat</subject><subject>Rats</subject><subject>Rats, Inbred F344</subject><subject>teratology</subject><subject>Teratology. Teratogens</subject><issn>0260-437X</issn><issn>1099-1263</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1v00AQxVcIVNKWa29Ie0DcHGa_vRKXqtA2KDQSskpvq8l6LbY4dvBu2ua_r6tEQZw4zeH93puZR8gZgykD4J_uMU-5UsAESFCvyISBtQXjWrwmE-AaCinM3VtynNI9wKjx8ogclcJow8WEfP4SHkLbr1ehy9jS3D9FH_OW9g1dVNWCNpvQ0tmMxo7mX4EOmCl29TiXy5hPyZsG2xTe7ecJqS6_VhfXxXxxNbs4nxdeWKEKaWvJmPEWG1UaqWqrBSLWsjS11-V4PQfUvLYgGxtAeiHV-IthCBiYECfk4y52PfR_NiFlt4rJh7bFLvSb5JgU3IB-Aac70A99SkNo3HqIKxy2joF7acuNbbm_bY2G9_vkzXIV6gO-r2fUP-x1TB7bZsDOx3TAZMl0qeWI2R32GNuw_c9S9-28-ueEYueNKYengxeH304bYZT7eXPl1FzbW3P7w30Xzw1zjvc</recordid><startdate>199307</startdate><enddate>199307</enddate><creator>Cooper, James R.</creator><creator>Lee, Lanfong H.</creator><creator>Macys, David A.</creator><general>John Wiley &amp; Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>C1K</scope><scope>SOI</scope></search><sort><creationdate>199307</creationdate><title>Developmental toxicity of OTTO fuel II in the rat and rabbit</title><author>Cooper, James R. ; Lee, Lanfong H. ; Macys, David A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3935-49d4117c9af58745d963aaad487dc6825520a62d904f9e04c34540571a0ae133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Body Weight - drug effects</topic><topic>Embryology: invertebrates and vertebrates. Teratology</topic><topic>Embryonic and Fetal Development - drug effects</topic><topic>Erythema - chemically induced</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>OTTO Fuel II</topic><topic>Pregnancy</topic><topic>propylene glycol dinitrate (PGDN)</topic><topic>Propylene Glycols - toxicity</topic><topic>rabbit</topic><topic>Rabbits</topic><topic>rat</topic><topic>Rats</topic><topic>Rats, Inbred F344</topic><topic>teratology</topic><topic>Teratology. Teratogens</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cooper, James R.</creatorcontrib><creatorcontrib>Lee, Lanfong H.</creatorcontrib><creatorcontrib>Macys, David A.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><jtitle>Journal of applied toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cooper, James R.</au><au>Lee, Lanfong H.</au><au>Macys, David A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Developmental toxicity of OTTO fuel II in the rat and rabbit</atitle><jtitle>Journal of applied toxicology</jtitle><addtitle>J. Appl. Toxicol</addtitle><date>1993-07</date><risdate>1993</risdate><volume>13</volume><issue>4</issue><spage>235</spage><epage>239</epage><pages>235-239</pages><issn>0260-437X</issn><eissn>1099-1263</eissn><coden>JJATDK</coden><abstract>OTTO Fuel II (OFII) is a propellent used by the United States Navy in its Mk 46 and Mk 48 torpedoes. Owing to the possibility of human exposure during fueling and defueling operations, studies were initiated to determine if OFII was a developmental toxin. Phase I of the investigation involved dosing four groups of time‐mated Fischer‐344 rats with OFII. The fuel was administered dermally at the rate of 0, 400, 2000 and 4000 mg kg−1 day−1. A significant reduction in body weight was seen at necropsy in dams receiving 2000 and 4000 mg kg−1 day−1 of OFII. Fetuses from these dams also weighed significantly less than control fetuses. Phase II of the investigation involved dosing of artificially inseminated rabbits with OFII. The fuel was administered to the skin of the animal's back at the rate of 0, 100, 316 and 1000 mg kg−1 day−1. Maternal toxicity was evidenced by a significant reduction in body weight of the dams in the 1000 mg kg−1 day−1 dose group on days 20 and 25 of gestation. There were no significant differences observed in maternal weight or fetal weight at necropsy. Morphological examination of both rat and rabbit fetuses failed to reveal significant evidence of fetal malformations.</abstract><cop>Chichester</cop><pub>John Wiley &amp; Sons, Ltd</pub><pmid>8376723</pmid><doi>10.1002/jat.2550130405</doi><tpages>5</tpages></addata></record>
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source MEDLINE; Access via Wiley Online Library
subjects Animals
Biological and medical sciences
Body Weight - drug effects
Embryology: invertebrates and vertebrates. Teratology
Embryonic and Fetal Development - drug effects
Erythema - chemically induced
Female
Fundamental and applied biological sciences. Psychology
OTTO Fuel II
Pregnancy
propylene glycol dinitrate (PGDN)
Propylene Glycols - toxicity
rabbit
Rabbits
rat
Rats
Rats, Inbred F344
teratology
Teratology. Teratogens
title Developmental toxicity of OTTO fuel II in the rat and rabbit
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