The mutagenic properties of N-nitrosopeptides in the Ames test
N-(N- Acetyl- l-prolyl )-N- nitrosoglycine (APNG) and N-( N-acetylvalyl)- N-nitrosoglycine (AVNG) are shown to exert mutagenic activity in the Salmonella/mammalian microsome mutagenicity (Ames) test. Positive responses are apparent for base-pair substitution mutation-detecting strains (TA1535, TA100...
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| Veröffentlicht in: | Toxicology letters 1985-01, Vol.26 (2), p.89-93 |
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| container_end_page | 93 |
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| container_issue | 2 |
| container_start_page | 89 |
| container_title | Toxicology letters |
| container_volume | 26 |
| creator | Challis, Brian C. Hopkins, Andrew R. Milligan, James R. Massey, Robert C. Anderson, Diana Blowers, Stephen D. |
| description | N-(N-
Acetyl-
l-prolyl
)-N-
nitrosoglycine
(APNG) and
N-(
N-acetylvalyl)-
N-nitrosoglycine (AVNG) are shown to exert mutagenic activity in the
Salmonella/mammalian microsome mutagenicity (Ames) test. Positive responses are apparent for base-pair substitution mutation-detecting strains (TA1535, TA100 and TA 102) both with and without the addition of S9-mix. It is concluded that both APNG and AVNG are direct-acting mutagens. |
| doi_str_mv | 10.1016/0378-4274(85)90150-X |
| format | Article |
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Acetyl-
l-prolyl
)-N-
nitrosoglycine
(APNG) and
N-(
N-acetylvalyl)-
N-nitrosoglycine (AVNG) are shown to exert mutagenic activity in the
Salmonella/mammalian microsome mutagenicity (Ames) test. Positive responses are apparent for base-pair substitution mutation-detecting strains (TA1535, TA100 and TA 102) both with and without the addition of S9-mix. It is concluded that both APNG and AVNG are direct-acting mutagens.</description><identifier>ISSN: 0378-4274</identifier><identifier>EISSN: 1879-3169</identifier><identifier>DOI: 10.1016/0378-4274(85)90150-X</identifier><identifier>PMID: 3898471</identifier><language>eng</language><publisher>Netherlands: Elsevier Ireland Ltd</publisher><subject>Ames test ; Animals ; Biotransformation ; In Vitro Techniques ; Liver - metabolism ; Male ; mutagenicity ; Mutagenicity Tests ; Mutagens ; Nitrosamines - toxicity ; Nitrosopeptides ; Rats ; Rats, Inbred Strains ; Salmonella typhimurium - drug effects ; Salmonella typhimurium - genetics</subject><ispartof>Toxicology letters, 1985-01, Vol.26 (2), p.89-93</ispartof><rights>1985</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-941cb3e5174e408647448643183d6999585f77caeb29b8a6b9d171948114cb373</citedby><cites>FETCH-LOGICAL-c388t-941cb3e5174e408647448643183d6999585f77caeb29b8a6b9d171948114cb373</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0378-4274(85)90150-X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3898471$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Challis, Brian C.</creatorcontrib><creatorcontrib>Hopkins, Andrew R.</creatorcontrib><creatorcontrib>Milligan, James R.</creatorcontrib><creatorcontrib>Massey, Robert C.</creatorcontrib><creatorcontrib>Anderson, Diana</creatorcontrib><creatorcontrib>Blowers, Stephen D.</creatorcontrib><title>The mutagenic properties of N-nitrosopeptides in the Ames test</title><title>Toxicology letters</title><addtitle>Toxicol Lett</addtitle><description>N-(N-
Acetyl-
l-prolyl
)-N-
nitrosoglycine
(APNG) and
N-(
N-acetylvalyl)-
N-nitrosoglycine (AVNG) are shown to exert mutagenic activity in the
Salmonella/mammalian microsome mutagenicity (Ames) test. Positive responses are apparent for base-pair substitution mutation-detecting strains (TA1535, TA100 and TA 102) both with and without the addition of S9-mix. It is concluded that both APNG and AVNG are direct-acting mutagens.</description><subject>Ames test</subject><subject>Animals</subject><subject>Biotransformation</subject><subject>In Vitro Techniques</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>mutagenicity</subject><subject>Mutagenicity Tests</subject><subject>Mutagens</subject><subject>Nitrosamines - toxicity</subject><subject>Nitrosopeptides</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Salmonella typhimurium - drug effects</subject><subject>Salmonella typhimurium - genetics</subject><issn>0378-4274</issn><issn>1879-3169</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1PwzAMhiMEGmPwD0DqCcGhEDdpPi5I08SXNMFlSLtFbepC0NqOJkXi35OxaUcujmW_r-08hJwDvQEK4pYyqVKeSX6l8mtNIafp8oCMQUmdMhD6kIz3kmNy4v0npVRwkY_IiCmtuIQxuVt8YNIMoXjH1tlk3Xdr7INDn3R18pK2LvSdj7V1cFUsujYJ0TBtYh7Qh1NyVBcrj2e7d0LeHu4Xs6d0_vr4PJvOU8uUCqnmYEuGOUiOnCrBJecxMlCsElrrXOW1lLbAMtOlKkSpK5CguQLg0SjZhFxu58YDv4a42DTOW1ytiha7wRvgLBNZBlHIt0Ib7_Y91mbdu6bofwxQs8FmNkzMholRufnDZpbRdrGbP5QNVnvTjlPs3237GD_57bA33jpsLVauRxtM1bn_F_wCrYF6gA</recordid><startdate>19850101</startdate><enddate>19850101</enddate><creator>Challis, Brian C.</creator><creator>Hopkins, Andrew R.</creator><creator>Milligan, James R.</creator><creator>Massey, Robert C.</creator><creator>Anderson, Diana</creator><creator>Blowers, Stephen D.</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>19850101</creationdate><title>The mutagenic properties of N-nitrosopeptides in the Ames test</title><author>Challis, Brian C. ; Hopkins, Andrew R. ; Milligan, James R. ; Massey, Robert C. ; Anderson, Diana ; Blowers, Stephen D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-941cb3e5174e408647448643183d6999585f77caeb29b8a6b9d171948114cb373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Ames test</topic><topic>Animals</topic><topic>Biotransformation</topic><topic>In Vitro Techniques</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>mutagenicity</topic><topic>Mutagenicity Tests</topic><topic>Mutagens</topic><topic>Nitrosamines - toxicity</topic><topic>Nitrosopeptides</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Salmonella typhimurium - drug effects</topic><topic>Salmonella typhimurium - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Challis, Brian C.</creatorcontrib><creatorcontrib>Hopkins, Andrew R.</creatorcontrib><creatorcontrib>Milligan, James R.</creatorcontrib><creatorcontrib>Massey, Robert C.</creatorcontrib><creatorcontrib>Anderson, Diana</creatorcontrib><creatorcontrib>Blowers, Stephen D.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Toxicology letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Challis, Brian C.</au><au>Hopkins, Andrew R.</au><au>Milligan, James R.</au><au>Massey, Robert C.</au><au>Anderson, Diana</au><au>Blowers, Stephen D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The mutagenic properties of N-nitrosopeptides in the Ames test</atitle><jtitle>Toxicology letters</jtitle><addtitle>Toxicol Lett</addtitle><date>1985-01-01</date><risdate>1985</risdate><volume>26</volume><issue>2</issue><spage>89</spage><epage>93</epage><pages>89-93</pages><issn>0378-4274</issn><eissn>1879-3169</eissn><abstract>N-(N-
Acetyl-
l-prolyl
)-N-
nitrosoglycine
(APNG) and
N-(
N-acetylvalyl)-
N-nitrosoglycine (AVNG) are shown to exert mutagenic activity in the
Salmonella/mammalian microsome mutagenicity (Ames) test. Positive responses are apparent for base-pair substitution mutation-detecting strains (TA1535, TA100 and TA 102) both with and without the addition of S9-mix. It is concluded that both APNG and AVNG are direct-acting mutagens.</abstract><cop>Netherlands</cop><pub>Elsevier Ireland Ltd</pub><pmid>3898471</pmid><doi>10.1016/0378-4274(85)90150-X</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0378-4274 |
| ispartof | Toxicology letters, 1985-01, Vol.26 (2), p.89-93 |
| issn | 0378-4274 1879-3169 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_14326221 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Ames test Animals Biotransformation In Vitro Techniques Liver - metabolism Male mutagenicity Mutagenicity Tests Mutagens Nitrosamines - toxicity Nitrosopeptides Rats Rats, Inbred Strains Salmonella typhimurium - drug effects Salmonella typhimurium - genetics |
| title | The mutagenic properties of N-nitrosopeptides in the Ames test |
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