The mutagenic properties of N-nitrosopeptides in the Ames test

The mutagenic properties of N-nitrosopeptides in the Ames test

N-(N- Acetyl- l-prolyl )-N- nitrosoglycine (APNG) and N-( N-acetylvalyl)- N-nitrosoglycine (AVNG) are shown to exert mutagenic activity in the Salmonella/mammalian microsome mutagenicity (Ames) test. Positive responses are apparent for base-pair substitution mutation-detecting strains (TA1535, TA100...

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Veröffentlicht in:Toxicology letters 1985-01, Vol.26 (2), p.89-93
Hauptverfasser: Challis, Brian C., Hopkins, Andrew R., Milligan, James R., Massey, Robert C., Anderson, Diana, Blowers, Stephen D.
Format: Artikel
Sprache:eng
Schlagworte:
Ames test
Animals
Biotransformation
In Vitro Techniques
Liver - metabolism
Male
mutagenicity
Mutagenicity Tests
Mutagens
Nitrosamines - toxicity
Nitrosopeptides
Rats
Rats, Inbred Strains
Salmonella typhimurium - drug effects
Salmonella typhimurium - genetics
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Zusammenfassung:N-(N- Acetyl- l-prolyl )-N- nitrosoglycine (APNG) and N-( N-acetylvalyl)- N-nitrosoglycine (AVNG) are shown to exert mutagenic activity in the Salmonella/mammalian microsome mutagenicity (Ames) test. Positive responses are apparent for base-pair substitution mutation-detecting strains (TA1535, TA100 and TA 102) both with and without the addition of S9-mix. It is concluded that both APNG and AVNG are direct-acting mutagens.
ISSN:0378-4274
1879-3169
DOI:10.1016/0378-4274(85)90150-X