COMT Val158Met Polymorphism and Executive Functions in Obsessive-Compulsive Disorder
This study investigated the association between the catechol-O-methyl transferase (COMT) Val158Met polymorphism and executive functions in 101 patients with obsessive-compulsive disorder (OCD) and 100 healthy-control subjects (HS). Results showed that there was no significant difference for the geno...
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| Veröffentlicht in: | The journal of neuropsychiatry and clinical neurosciences 2013-07, Vol.25 (3), p.214-221 |
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| container_title | The journal of neuropsychiatry and clinical neurosciences |
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| creator | Tükel, Raşit Gürvit, Hakan Öztürk, Nalan Özata, Berna Ertekin, Banu Aslantaş Ertekin, Erhan Baran, Bengi Kalem, Şükriye Akça Büyükgök, Deniz Direskeneli, Güher Saruhan |
| description | This study investigated the association between the catechol-O-methyl transferase (COMT) Val158Met polymorphism and executive functions in 101 patients with obsessive-compulsive disorder (OCD) and 100 healthy-control subjects (HS). Results showed that there was no significant difference for the genotype distributions between the OCD and HS groups. OCD-Met carrier subgroup's TMT B-A difference and lexical fluency scores were found to be significantly poorer than both HS subgroups. These findings suggest that lower activity of COMT associated with the Met allele, leading to higher levels of dopamine in the prefrontal cortex, lead to poorer executive function in OCD. |
| doi_str_mv | 10.1176/appi.neuropsych.12040103 |
| format | Article |
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Results showed that there was no significant difference for the genotype distributions between the OCD and HS groups. OCD-Met carrier subgroup's TMT B-A difference and lexical fluency scores were found to be significantly poorer than both HS subgroups. These findings suggest that lower activity of COMT associated with the Met allele, leading to higher levels of dopamine in the prefrontal cortex, lead to poorer executive function in OCD.</description><identifier>ISSN: 0895-0172</identifier><identifier>EISSN: 1545-7222</identifier><identifier>DOI: 10.1176/appi.neuropsych.12040103</identifier><identifier>PMID: 23774999</identifier><identifier>CODEN: JNCNE7</identifier><language>eng</language><publisher>Arlington, VA: American Psychiatric Association</publisher><subject>Adult ; Adult and adolescent clinical studies ; Analysis of Variance ; Anxiety disorders. 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Psychiatry ; Valine - genetics ; Young Adult</subject><ispartof>The journal of neuropsychiatry and clinical neurosciences, 2013-07, Vol.25 (3), p.214-221</ispartof><rights>Copyright © 2013 American Psychiatric Association 2013</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2013 American Psychiatric Association</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a535t-c7806b7819a354815efe95a0de185e43cf4cbb7b6c608e4e5edec400e3bf60d13</citedby><cites>FETCH-LOGICAL-a535t-c7806b7819a354815efe95a0de185e43cf4cbb7b6c608e4e5edec400e3bf60d13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://psychiatryonline.org/doi/epdf/10.1176/appi.neuropsych.12040103$$EPDF$$P50$$Gappi$$H</linktopdf><linktohtml>$$Uhttps://psychiatryonline.org/doi/full/10.1176/appi.neuropsych.12040103$$EHTML$$P50$$Gappi$$H</linktohtml><link.rule.ids>314,780,784,2846,21617,21618,21619,27915,27916,77555,77560</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27667377$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23774999$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tükel, Raşit</creatorcontrib><creatorcontrib>Gürvit, Hakan</creatorcontrib><creatorcontrib>Öztürk, Nalan</creatorcontrib><creatorcontrib>Özata, Berna</creatorcontrib><creatorcontrib>Ertekin, Banu Aslantaş</creatorcontrib><creatorcontrib>Ertekin, Erhan</creatorcontrib><creatorcontrib>Baran, Bengi</creatorcontrib><creatorcontrib>Kalem, Şükriye Akça</creatorcontrib><creatorcontrib>Büyükgök, Deniz</creatorcontrib><creatorcontrib>Direskeneli, Güher Saruhan</creatorcontrib><title>COMT Val158Met Polymorphism and Executive Functions in Obsessive-Compulsive Disorder</title><title>The journal of neuropsychiatry and clinical neurosciences</title><addtitle>J Neuropsychiatry Clin Neurosci</addtitle><description>This study investigated the association between the catechol-O-methyl transferase (COMT) Val158Met polymorphism and executive functions in 101 patients with obsessive-compulsive disorder (OCD) and 100 healthy-control subjects (HS). Results showed that there was no significant difference for the genotype distributions between the OCD and HS groups. OCD-Met carrier subgroup's TMT B-A difference and lexical fluency scores were found to be significantly poorer than both HS subgroups. These findings suggest that lower activity of COMT associated with the Met allele, leading to higher levels of dopamine in the prefrontal cortex, lead to poorer executive function in OCD.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Analysis of Variance</subject><subject>Anxiety disorders. Neuroses</subject><subject>Biological and medical sciences</subject><subject>Catechol O-Methyltransferase - genetics</subject><subject>Cognition Disorders - etiology</subject><subject>Executive Function - physiology</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genotype</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Methionine - genetics</subject><subject>Neuropsychological Tests</subject><subject>Obsessive compulsive disorder</subject><subject>Obsessive-Compulsive Disorder - complications</subject><subject>Obsessive-Compulsive Disorder - genetics</subject><subject>Obsessive-compulsive disorders</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Psychiatric Status Rating Scales</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. 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Neuroses</topic><topic>Biological and medical sciences</topic><topic>Catechol O-Methyltransferase - genetics</topic><topic>Cognition Disorders - etiology</topic><topic>Executive Function - physiology</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genotype</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Methionine - genetics</topic><topic>Neuropsychological Tests</topic><topic>Obsessive compulsive disorder</topic><topic>Obsessive-Compulsive Disorder - complications</topic><topic>Obsessive-Compulsive Disorder - genetics</topic><topic>Obsessive-compulsive disorders</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Psychiatric Status Rating Scales</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. 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| source | MEDLINE; American Psychiatric Publishing Journals (1997-Present); EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Adult and adolescent clinical studies Analysis of Variance Anxiety disorders. Neuroses Biological and medical sciences Catechol O-Methyltransferase - genetics Cognition Disorders - etiology Executive Function - physiology Female Gene Frequency Genotype Humans Male Medical sciences Methionine - genetics Neuropsychological Tests Obsessive compulsive disorder Obsessive-Compulsive Disorder - complications Obsessive-Compulsive Disorder - genetics Obsessive-compulsive disorders Polymorphism, Single Nucleotide - genetics Psychiatric Status Rating Scales Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Valine - genetics Young Adult |
| title | COMT Val158Met Polymorphism and Executive Functions in Obsessive-Compulsive Disorder |
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