Effect of testosterone replacement therapy on cardiac performance and oxidative stress in orchidectomized rats

Aim To investigate the effects of testosterone on myocardial contractility, oxidative stress status and expression of sodium channel protein (Nav1.5) and inward rectifying K channels (Kir 2.x) in normal and orchidectomized (ORX) rats. Methods One hundred four rats were randomly assigned into four gr...

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Veröffentlicht in:	Acta Physiologica 2013-10, Vol.209 (2), p.136-147
Hauptverfasser:	Eleawa, S. M., Sakr, H. F., Hussein, A. M., Assiri, A. S., Bayoumy, N. M. K., Alkhateeb, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals cardiac performance Electrocardiography Heart - drug effects Heart - physiology Hormone Replacement Therapy Immunohistochemistry Kir2.x channels Male Myocardial Contraction - drug effects Myocardial Contraction - physiology Nav1.5 channels NAV1.5 Voltage-Gated Sodium Channel - biosynthesis orchidectomy Orchiectomy oxidative stress Oxidative Stress - drug effects Oxidative Stress - physiology Potassium Channels, Inwardly Rectifying - biosynthesis Rats Rats, Sprague-Dawley Reverse Transcriptase Polymerase Chain Reaction testosterone Testosterone - pharmacology
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