Cellular capsules as a tool for multicellular spheroid production and for investigating the mechanics of tumor progression in vitro

Deciphering the multifactorial determinants of tumor progression requires standardized high-throughput preparation of 3D in vitro cellular assays. We present a simple microfluidic method based on the encapsulation and growth of cells inside permeable, elastic, hollow microspheres. We show that this...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2013-09, Vol.110 (37), p.14843-14848
Hauptverfasser:	Alessandri, Kévin, Sarangi, Bibhu Ranjan, Gurchenkov, Vasily Valérïévitch, Sinha, Bidisha, Kießling, Tobias Reinhold, Fetler, Luc, Rico, Felix, Scheuring, Simon, Lamaze, Christophe, Simon, Anthony, Geraldo, Sara, Vignjević, Danijela, Doméjean, Hugo, Rolland, Leslie, Funfak, Anette, Bibette, Jérôme, Bremond, Nicolas, Nassoy, Pierre
Format:	Artikel
Sprache:	eng
Schlagworte:	Alginates Animals Biochemistry, Molecular Biology Biological Physics Biological Sciences Biomechanical Phenomena Capsules Cell Count Cell culture techniques Cell growth Cell Line, Tumor Cell Movement Cell Proliferation Cells Collagen Disease Progression Elasticity Gels Glucuronic Acid HeLa Cells Hexuronic Acids Homeostasis Humans Hydrogels Life Sciences Liquids Mechanotransduction, Cellular Mice Microfluidic Analytical Techniques - instrumentation Neoplasm Invasiveness - pathology Neoplasm Invasiveness - physiopathology Physical Sciences Physics Spheroids Spheroids, Cellular - pathology Spheroids, Cellular - physiology Tumor Microenvironment Tumors
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