The regulation and function of the NUAK family
AMP-activated protein kinase (AMPK) is a critical regulator of cellular and whole-body energy homeostasis. Twelve AMPK-related kinases (ARKs; BRSK1, BRSK2, NUAK1, NUAK2, QIK, QSK, SIK, MARK1, MARK2, MARK3, MARK4, and MELK) have been identified recently. These kinases show a similar structural organi...
Gespeichert in:
| Veröffentlicht in: | Journal of molecular endocrinology 2013-10, Vol.51 (2), p.R15-R22 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | R22 |
|---|---|
| container_issue | 2 |
| container_start_page | R15 |
| container_title | Journal of molecular endocrinology |
| container_volume | 51 |
| creator | Sun, Xianglan Gao, Ling Chien, Hung-Yu Li, Wan-Chun Zhao, Jiajun |
| description | AMP-activated protein kinase (AMPK) is a critical regulator of cellular and whole-body energy homeostasis. Twelve AMPK-related kinases (ARKs; BRSK1, BRSK2, NUAK1, NUAK2, QIK, QSK, SIK, MARK1, MARK2, MARK3, MARK4, and MELK) have been identified recently. These kinases show a similar structural organization, including an N-terminal catalytic domain, followed by a ubiquitin-associated domain and a C-terminal spacer sequence, which in some cases also contains a kinase-associated domain 1. Eleven of the ARKs are phosphorylated and activated by the master upstream kinase liver kinase B1. However, most of these ARKs are largely unknown, and the NUAK family seems to have different regulations and functions. This review contains a brief discussion of the NUAK family including the specific characteristics of NUAK1 and NUAK2. |
| doi_str_mv | 10.1530/JME-13-0063 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1432075393</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1432075393</sourcerecordid><originalsourceid>FETCH-LOGICAL-b476t-d1db4390a194bf3b065dee09af9cdf5cdb10cc68df446ba99860fc9c3c9ea6393</originalsourceid><addsrcrecordid>eNp90DtPwzAUhmELgWgpTOwoIxJKOad2nHqsqnItsLSz5SsY5VLiZOi_J6WFkck68qNveAm5RBhjRuH26WWRIk0BOD0iQ2S5SPkU6TEZgsgmaQYMB-Qsxk8AzDBnp2QwodOcUsQhGa8-XNK4965QbairRFU28V1lfo7aJ23__bqePSdelaHYnpMTr4roLg7viKzvFqv5Q7p8u3-cz5apZjlvU4tWMypAoWDaUw08s86BUF4Y6zNjNYIxfGo9Y1wrIaYcvBGGGuEUp4KOyPV-d9PUX52LrSxDNK4oVOXqLkpkdAJ51sue3uypaeoYG-flpgmlarYSQe4CyT6QRCp3gXp9dRjudOnsn_0t0gPcAx3qaIKr2uCDUf-OfgPUcG9h</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1432075393</pqid></control><display><type>article</type><title>The regulation and function of the NUAK family</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Society for Endocrinology Journals</source><creator>Sun, Xianglan ; Gao, Ling ; Chien, Hung-Yu ; Li, Wan-Chun ; Zhao, Jiajun</creator><creatorcontrib>Sun, Xianglan ; Gao, Ling ; Chien, Hung-Yu ; Li, Wan-Chun ; Zhao, Jiajun</creatorcontrib><description>AMP-activated protein kinase (AMPK) is a critical regulator of cellular and whole-body energy homeostasis. Twelve AMPK-related kinases (ARKs; BRSK1, BRSK2, NUAK1, NUAK2, QIK, QSK, SIK, MARK1, MARK2, MARK3, MARK4, and MELK) have been identified recently. These kinases show a similar structural organization, including an N-terminal catalytic domain, followed by a ubiquitin-associated domain and a C-terminal spacer sequence, which in some cases also contains a kinase-associated domain 1. Eleven of the ARKs are phosphorylated and activated by the master upstream kinase liver kinase B1. However, most of these ARKs are largely unknown, and the NUAK family seems to have different regulations and functions. This review contains a brief discussion of the NUAK family including the specific characteristics of NUAK1 and NUAK2.</description><identifier>ISSN: 0952-5041</identifier><identifier>EISSN: 1479-6813</identifier><identifier>DOI: 10.1530/JME-13-0063</identifier><identifier>PMID: 23873311</identifier><language>eng</language><publisher>England: Society for Endocrinology</publisher><subject>AMP-Activated Protein Kinases - chemistry ; AMP-Activated Protein Kinases - genetics ; AMP-Activated Protein Kinases - metabolism ; Animals ; Humans ; Protein Kinases - chemistry ; Protein Kinases - genetics ; Protein Kinases - metabolism ; Protein-Serine-Threonine Kinases - chemistry ; Protein-Serine-Threonine Kinases - genetics ; Protein-Serine-Threonine Kinases - metabolism ; Review</subject><ispartof>Journal of molecular endocrinology, 2013-10, Vol.51 (2), p.R15-R22</ispartof><rights>2013 Society for Endocrinology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b476t-d1db4390a194bf3b065dee09af9cdf5cdb10cc68df446ba99860fc9c3c9ea6393</citedby><cites>FETCH-LOGICAL-b476t-d1db4390a194bf3b065dee09af9cdf5cdb10cc68df446ba99860fc9c3c9ea6393</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3950,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23873311$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sun, Xianglan</creatorcontrib><creatorcontrib>Gao, Ling</creatorcontrib><creatorcontrib>Chien, Hung-Yu</creatorcontrib><creatorcontrib>Li, Wan-Chun</creatorcontrib><creatorcontrib>Zhao, Jiajun</creatorcontrib><title>The regulation and function of the NUAK family</title><title>Journal of molecular endocrinology</title><addtitle>J Mol Endocrinol</addtitle><description>AMP-activated protein kinase (AMPK) is a critical regulator of cellular and whole-body energy homeostasis. Twelve AMPK-related kinases (ARKs; BRSK1, BRSK2, NUAK1, NUAK2, QIK, QSK, SIK, MARK1, MARK2, MARK3, MARK4, and MELK) have been identified recently. These kinases show a similar structural organization, including an N-terminal catalytic domain, followed by a ubiquitin-associated domain and a C-terminal spacer sequence, which in some cases also contains a kinase-associated domain 1. Eleven of the ARKs are phosphorylated and activated by the master upstream kinase liver kinase B1. However, most of these ARKs are largely unknown, and the NUAK family seems to have different regulations and functions. This review contains a brief discussion of the NUAK family including the specific characteristics of NUAK1 and NUAK2.</description><subject>AMP-Activated Protein Kinases - chemistry</subject><subject>AMP-Activated Protein Kinases - genetics</subject><subject>AMP-Activated Protein Kinases - metabolism</subject><subject>Animals</subject><subject>Humans</subject><subject>Protein Kinases - chemistry</subject><subject>Protein Kinases - genetics</subject><subject>Protein Kinases - metabolism</subject><subject>Protein-Serine-Threonine Kinases - chemistry</subject><subject>Protein-Serine-Threonine Kinases - genetics</subject><subject>Protein-Serine-Threonine Kinases - metabolism</subject><subject>Review</subject><issn>0952-5041</issn><issn>1479-6813</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90DtPwzAUhmELgWgpTOwoIxJKOad2nHqsqnItsLSz5SsY5VLiZOi_J6WFkck68qNveAm5RBhjRuH26WWRIk0BOD0iQ2S5SPkU6TEZgsgmaQYMB-Qsxk8AzDBnp2QwodOcUsQhGa8-XNK4965QbairRFU28V1lfo7aJ23__bqePSdelaHYnpMTr4roLg7viKzvFqv5Q7p8u3-cz5apZjlvU4tWMypAoWDaUw08s86BUF4Y6zNjNYIxfGo9Y1wrIaYcvBGGGuEUp4KOyPV-d9PUX52LrSxDNK4oVOXqLkpkdAJ51sue3uypaeoYG-flpgmlarYSQe4CyT6QRCp3gXp9dRjudOnsn_0t0gPcAx3qaIKr2uCDUf-OfgPUcG9h</recordid><startdate>20131001</startdate><enddate>20131001</enddate><creator>Sun, Xianglan</creator><creator>Gao, Ling</creator><creator>Chien, Hung-Yu</creator><creator>Li, Wan-Chun</creator><creator>Zhao, Jiajun</creator><general>Society for Endocrinology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20131001</creationdate><title>The regulation and function of the NUAK family</title><author>Sun, Xianglan ; Gao, Ling ; Chien, Hung-Yu ; Li, Wan-Chun ; Zhao, Jiajun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b476t-d1db4390a194bf3b065dee09af9cdf5cdb10cc68df446ba99860fc9c3c9ea6393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>AMP-Activated Protein Kinases - chemistry</topic><topic>AMP-Activated Protein Kinases - genetics</topic><topic>AMP-Activated Protein Kinases - metabolism</topic><topic>Animals</topic><topic>Humans</topic><topic>Protein Kinases - chemistry</topic><topic>Protein Kinases - genetics</topic><topic>Protein Kinases - metabolism</topic><topic>Protein-Serine-Threonine Kinases - chemistry</topic><topic>Protein-Serine-Threonine Kinases - genetics</topic><topic>Protein-Serine-Threonine Kinases - metabolism</topic><topic>Review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sun, Xianglan</creatorcontrib><creatorcontrib>Gao, Ling</creatorcontrib><creatorcontrib>Chien, Hung-Yu</creatorcontrib><creatorcontrib>Li, Wan-Chun</creatorcontrib><creatorcontrib>Zhao, Jiajun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of molecular endocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sun, Xianglan</au><au>Gao, Ling</au><au>Chien, Hung-Yu</au><au>Li, Wan-Chun</au><au>Zhao, Jiajun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The regulation and function of the NUAK family</atitle><jtitle>Journal of molecular endocrinology</jtitle><addtitle>J Mol Endocrinol</addtitle><date>2013-10-01</date><risdate>2013</risdate><volume>51</volume><issue>2</issue><spage>R15</spage><epage>R22</epage><pages>R15-R22</pages><issn>0952-5041</issn><eissn>1479-6813</eissn><abstract>AMP-activated protein kinase (AMPK) is a critical regulator of cellular and whole-body energy homeostasis. Twelve AMPK-related kinases (ARKs; BRSK1, BRSK2, NUAK1, NUAK2, QIK, QSK, SIK, MARK1, MARK2, MARK3, MARK4, and MELK) have been identified recently. These kinases show a similar structural organization, including an N-terminal catalytic domain, followed by a ubiquitin-associated domain and a C-terminal spacer sequence, which in some cases also contains a kinase-associated domain 1. Eleven of the ARKs are phosphorylated and activated by the master upstream kinase liver kinase B1. However, most of these ARKs are largely unknown, and the NUAK family seems to have different regulations and functions. This review contains a brief discussion of the NUAK family including the specific characteristics of NUAK1 and NUAK2.</abstract><cop>England</cop><pub>Society for Endocrinology</pub><pmid>23873311</pmid><doi>10.1530/JME-13-0063</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0952-5041 |
| ispartof | Journal of molecular endocrinology, 2013-10, Vol.51 (2), p.R15-R22 |
| issn | 0952-5041 1479-6813 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1432075393 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Society for Endocrinology Journals |
| subjects | AMP-Activated Protein Kinases - chemistry AMP-Activated Protein Kinases - genetics AMP-Activated Protein Kinases - metabolism Animals Humans Protein Kinases - chemistry Protein Kinases - genetics Protein Kinases - metabolism Protein-Serine-Threonine Kinases - chemistry Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Review |
| title | The regulation and function of the NUAK family |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-20T05%3A54%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20regulation%20and%20function%20of%20the%20NUAK%20family&rft.jtitle=Journal%20of%20molecular%20endocrinology&rft.au=Sun,%20Xianglan&rft.date=2013-10-01&rft.volume=51&rft.issue=2&rft.spage=R15&rft.epage=R22&rft.pages=R15-R22&rft.issn=0952-5041&rft.eissn=1479-6813&rft_id=info:doi/10.1530/JME-13-0063&rft_dat=%3Cproquest_cross%3E1432075393%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1432075393&rft_id=info:pmid/23873311&rfr_iscdi=true |