Tracer level radiochemistry to clinical dose preparation of (177)Lu-labeled cyclic RGD peptide dimer

Integrin αvβ3 plays a significant role in angiogenesis during tumor growth and metastasis, and is a receptor for the extracellular matrix proteins with the exposed arginine(R)-glycine(G)-aspartic acid(D) tripeptide sequence. The over-expression of integrin αvβ3 during tumor growth and metastasis pre...

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Veröffentlicht in:	Nuclear medicine and biology 2013-10, Vol.40 (7), p.946-954
Hauptverfasser:	Chakraborty, Sudipta, Sarma, H D, Vimalnath, K V, Pillai, M R A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Dimerization Drug Stability Heterocyclic Compounds, 1-Ring - chemistry Humans Isotope Labeling Lutetium - therapeutic use Melanoma - radiotherapy Mice Octanols - chemistry Peptides, Cyclic - chemistry Peptides, Cyclic - pharmacokinetics Peptides, Cyclic - therapeutic use Radiation Dosage Radioactive Tracers Radiochemistry - methods Radioisotopes - therapeutic use Water - chemistry
Online-Zugang:	Volltext
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