Calycosin and formononetin from astragalus root enhance dimethylarginine dimethylaminohydrolase 2 and nitric oxide synthase expressions in Madin Darby Canine Kidney II cells

Nitric oxide (NO) is a crucial vasodilator produced by nitric oxide synthase (NOS). Asymmetric dimethylarginine (ADMA) is an endogenous NOS inhibitor and mainly catabolized by dimethylarginine dimethylaminohydrolase (DDAH). As we reported, the antihypertensive effect of shichimotsukokato (SKT), a fo...

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Veröffentlicht in:	Journal of natural medicines 2013-10, Vol.67 (4), p.782-789
Hauptverfasser:	Bai, Fan, Makino, Toshiaki, Kono, Keiko, Nagatsu, Akito, Ono, Takahiko, Mizukami, Hajime
Format:	Artikel
Sprache:	eng
Schlagworte:	active ingredients Amidohydrolases - metabolism Animals Antihypertensive Agents - chemistry Antihypertensive Agents - pharmacology antihypertensive effect Astragalus Plant - chemistry Biomedical and Life Sciences Biomedicine Complementary & Alternative Medicine Dogs drugs formononetin gene expression Isoflavones - pharmacology kidneys Madin Darby Canine Kidney Cells Medicinal Chemistry medicine messenger RNA nitric oxide nitric oxide synthase Nitric Oxide Synthase - metabolism Original Paper Pharmacology/Toxicology Pharmacy Plant Extracts - chemistry Plant Extracts - pharmacology Plant Roots - chemistry Plant Sciences rats
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