Nrf2 signalling promotes ex vivo tubular epithelial cell survival and regeneration via murine double minute (MDM)-2

Tubular repair upon injury involves regeneration from either surviving tubular epithelial cells or from their surviving local progenitor cells; hence, compound screening with cell lines may be inadequate. Here, we demonstrate that the renal cell isolation procedure and subsequent outgrowth of tubula...

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Veröffentlicht in:	Nephrology, dialysis, transplantation dialysis, transplantation, 2013-08, Vol.28 (8), p.2028-2037
Hauptverfasser:	Hagemann, Jan H, Thomasova, Dana, Mulay, Shrikant R, Anders, Hans-Joachim
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Kidney Injury - genetics Acute Kidney Injury - metabolism Animals Anticarcinogenic Agents - pharmacology Blotting, Western Cell Survival Epithelial Cells - cytology Epithelial Cells - drug effects Epithelial Cells - physiology Flow Cytometry Isothiocyanates - pharmacology Kidney Tubules - cytology Kidney Tubules - drug effects Kidney Tubules - physiology Mice Mice, Inbred C57BL NF-E2-Related Factor 2 - chemistry NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism Oxidative Stress - drug effects Oxidative Stress - physiology Proto-Oncogene Proteins c-mdm2 - genetics Proto-Oncogene Proteins c-mdm2 - metabolism Real-Time Polymerase Chain Reaction Regeneration - drug effects Regeneration - physiology Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Wound Healing - drug effects
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