The effect of novel [3-fluoro-(2-phosphonoethoxy)propyl]purines on the inhibition of Plasmodium falciparum, Plasmodium vivax and human hypoxanthine–guanine–(xanthine) phosphoribosyltransferases

Protozoan parasites from the Plasmodiidae family are the causative agents of malaria. Inhibition of hypoxanthine–guanine–(xanthine) phosphoribosyltransferase (HG(X)PRT) has been suggested as a target for development of new anti-malarial therapeutics. Acyclic nucleoside phosphonates (ANPs) are potent...

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Veröffentlicht in:	European journal of medicinal chemistry 2013-09, Vol.67, p.81-89
Hauptverfasser:	Baszczyňski, Ondřej, Hocková, Dana, Janeba, Zlatko, Holý, Antonín, Jansa, Petr, Dračínský, Martin, Keough, Dianne T., Guddat, Luke W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiprotozoal Agents - chemical synthesis Antiprotozoal Agents - chemistry Antiprotozoal Agents - pharmacology Dose-Response Relationship, Drug Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Fluorine FPEP FPMP HG(X)PRT Humans Malaria Models, Molecular Molecular Structure Nucleoside phosphonates Parasitic Sensitivity Tests Pentosyltransferases - antagonists & inhibitors Pentosyltransferases - metabolism Plasmodium falciparum - drug effects Plasmodium vivax - drug effects Purines Purines - chemical synthesis Purines - chemistry Purines - pharmacology Structure-Activity Relationship
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