Biased Treg/Th17 balance away from regulatory toward inflammatory phenotype in relapsed multiple sclerosis and its correlation with severity of symptoms
Abstract The opposing immune functions of Treg and Th17 lymphocytes and the plasticity of Treg/Th17 differentiation, has led us to investigate the effects of their fluctuations and counterbalance in autoimmune condition of multiple sclerosis (MS). Evaluation of Treg and Th17 frequency in peripheral...
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| Veröffentlicht in: | Journal of neuroimmunology 2013-09, Vol.262 (1), p.106-112 |
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| container_title | Journal of neuroimmunology |
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| creator | Jamshidian, Azam Shaygannejad, Vahid Pourazar, Abbasali Zarkesh-Esfahani, Sayyed-Hamid Gharagozloo, Marjan |
| description | Abstract The opposing immune functions of Treg and Th17 lymphocytes and the plasticity of Treg/Th17 differentiation, has led us to investigate the effects of their fluctuations and counterbalance in autoimmune condition of multiple sclerosis (MS). Evaluation of Treg and Th17 frequency in peripheral blood of a group of relapsed MS patients, showed a decrease in Treg/Th17 ratio compared to that of healthy controls. A reverse correlation between these subsets was observed in controls but not in patient groups. Both Treg frequency and Treg/Th17 ratio were negatively correlated with severity of symptoms. There was shown to be an enduring increase in Treg frequency associated with MS disease. |
| doi_str_mv | 10.1016/j.jneuroim.2013.06.007 |
| format | Article |
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Evaluation of Treg and Th17 frequency in peripheral blood of a group of relapsed MS patients, showed a decrease in Treg/Th17 ratio compared to that of healthy controls. A reverse correlation between these subsets was observed in controls but not in patient groups. Both Treg frequency and Treg/Th17 ratio were negatively correlated with severity of symptoms. 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Evaluation of Treg and Th17 frequency in peripheral blood of a group of relapsed MS patients, showed a decrease in Treg/Th17 ratio compared to that of healthy controls. A reverse correlation between these subsets was observed in controls but not in patient groups. Both Treg frequency and Treg/Th17 ratio were negatively correlated with severity of symptoms. There was shown to be an enduring increase in Treg frequency associated with MS disease.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Allergy and Immunology</subject><subject>Female</subject><subject>Forkhead Transcription Factors - biosynthesis</subject><subject>Humans</subject><subject>Immunophenotyping</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multiple sclerosis</subject><subject>Multiple Sclerosis - immunology</subject><subject>Multiple Sclerosis - pathology</subject><subject>Multiple Sclerosis, Relapsing-Remitting - immunology</subject><subject>Multiple Sclerosis, Relapsing-Remitting - pathology</subject><subject>Neurology</subject><subject>Prodromal Symptoms</subject><subject>Recurrence</subject><subject>Severity of Illness Index</subject><subject>T-Lymphocytes, Regulatory - immunology</subject><subject>T-Lymphocytes, Regulatory - pathology</subject><subject>Th17</subject><subject>Th17 Cells - immunology</subject><subject>Th17 Cells - pathology</subject><subject>Treg</subject><subject>Young Adult</subject><issn>0165-5728</issn><issn>1872-8421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFks1u1TAQhSMEoreFV6i8ZHNT_-Zng4AKClIlFlzWluNMuA52HGynV3kTHhdHt2XBhpWl8TdnNHNOUVwTXBJMqpuxHCdYgjeupJiwElclxvWzYkeamu4bTsnzYpdBsRc1bS6KyxhHjIlgvH1ZXFDWcMErvit-fzAqQo8OAX7cHI6kRp2yatKA1EmtaAjeofy1WJV8WFHyJxV6ZKbBKufOtfkIk0_rDLmcWavmTdAtNpnZAoraQvDRRKSm3Jki0j5sWDJ-QieTjijCAwSTVuQHFFc3J-_iq-LFoGyE14_vVfH908fD7ef9_de7L7fv7_eaU5b2lJMW18CqjkNbk46LhnCmO0HrjjAuGNG8qVgn8kn6ugVKWt0C6_pGMVFl9Kp4c9adg_-1QEzSmajB5iOAX6LMCKEtp5RltDqjOu8TAwxyDsapsEqC5eaKHOWTK3JzReJKZldy4_XjjKVz0P9te7IhA-_OAORNHwwEGbWB7EJvAugke2_-P-PtPxLamsloZX_CCnH0S5jyHSWRkUosv23Z2KJBWI5FVQn2B5fvuR8</recordid><startdate>20130915</startdate><enddate>20130915</enddate><creator>Jamshidian, Azam</creator><creator>Shaygannejad, Vahid</creator><creator>Pourazar, Abbasali</creator><creator>Zarkesh-Esfahani, Sayyed-Hamid</creator><creator>Gharagozloo, Marjan</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130915</creationdate><title>Biased Treg/Th17 balance away from regulatory toward inflammatory phenotype in relapsed multiple sclerosis and its correlation with severity of symptoms</title><author>Jamshidian, Azam ; Shaygannejad, Vahid ; Pourazar, Abbasali ; Zarkesh-Esfahani, Sayyed-Hamid ; Gharagozloo, Marjan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-241907e36b4e971b458143cb527b134531c4863b5842d79e219c9e3bd8a356143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Allergy and Immunology</topic><topic>Female</topic><topic>Forkhead Transcription Factors - biosynthesis</topic><topic>Humans</topic><topic>Immunophenotyping</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multiple sclerosis</topic><topic>Multiple Sclerosis - immunology</topic><topic>Multiple Sclerosis - pathology</topic><topic>Multiple Sclerosis, Relapsing-Remitting - immunology</topic><topic>Multiple Sclerosis, Relapsing-Remitting - pathology</topic><topic>Neurology</topic><topic>Prodromal Symptoms</topic><topic>Recurrence</topic><topic>Severity of Illness Index</topic><topic>T-Lymphocytes, Regulatory - immunology</topic><topic>T-Lymphocytes, Regulatory - pathology</topic><topic>Th17</topic><topic>Th17 Cells - immunology</topic><topic>Th17 Cells - pathology</topic><topic>Treg</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jamshidian, Azam</creatorcontrib><creatorcontrib>Shaygannejad, Vahid</creatorcontrib><creatorcontrib>Pourazar, Abbasali</creatorcontrib><creatorcontrib>Zarkesh-Esfahani, Sayyed-Hamid</creatorcontrib><creatorcontrib>Gharagozloo, Marjan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neuroimmunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jamshidian, Azam</au><au>Shaygannejad, Vahid</au><au>Pourazar, Abbasali</au><au>Zarkesh-Esfahani, Sayyed-Hamid</au><au>Gharagozloo, Marjan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biased Treg/Th17 balance away from regulatory toward inflammatory phenotype in relapsed multiple sclerosis and its correlation with severity of symptoms</atitle><jtitle>Journal of neuroimmunology</jtitle><addtitle>J Neuroimmunol</addtitle><date>2013-09-15</date><risdate>2013</risdate><volume>262</volume><issue>1</issue><spage>106</spage><epage>112</epage><pages>106-112</pages><issn>0165-5728</issn><eissn>1872-8421</eissn><abstract>Abstract The opposing immune functions of Treg and Th17 lymphocytes and the plasticity of Treg/Th17 differentiation, has led us to investigate the effects of their fluctuations and counterbalance in autoimmune condition of multiple sclerosis (MS). Evaluation of Treg and Th17 frequency in peripheral blood of a group of relapsed MS patients, showed a decrease in Treg/Th17 ratio compared to that of healthy controls. A reverse correlation between these subsets was observed in controls but not in patient groups. Both Treg frequency and Treg/Th17 ratio were negatively correlated with severity of symptoms. There was shown to be an enduring increase in Treg frequency associated with MS disease.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>23845464</pmid><doi>10.1016/j.jneuroim.2013.06.007</doi><tpages>7</tpages></addata></record> |
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| ispartof | Journal of neuroimmunology, 2013-09, Vol.262 (1), p.106-112 |
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| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adolescent Adult Allergy and Immunology Female Forkhead Transcription Factors - biosynthesis Humans Immunophenotyping Male Middle Aged Multiple sclerosis Multiple Sclerosis - immunology Multiple Sclerosis - pathology Multiple Sclerosis, Relapsing-Remitting - immunology Multiple Sclerosis, Relapsing-Remitting - pathology Neurology Prodromal Symptoms Recurrence Severity of Illness Index T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - pathology Th17 Th17 Cells - immunology Th17 Cells - pathology Treg Young Adult |
| title | Biased Treg/Th17 balance away from regulatory toward inflammatory phenotype in relapsed multiple sclerosis and its correlation with severity of symptoms |
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