New inhibitors of α-glucosidase in Salacia hainanensis Chun et How
The methanol extract from roots of Salacia hainanensis Chun et How afforded three new compounds, 24,26-dihydroxy-25-methoxy-tirucall-9-en-3-one (1), 2β,3β,22α-trihydroxy-lup-20(29)-ene (2) and 3β-hydroxy-2-carbonyl-lupan-29-oic acid (3), along with six known triterpenoids (4–9). Their structures wer...
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| Veröffentlicht in: | Journal of natural medicines 2013-10, Vol.67 (4), p.844-849 |
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| container_title | Journal of natural medicines |
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| creator | Guo, Zheng-hong Huang, Jian Wan, Guo-sheng Huo, Xiao-ling Gao, Hui-Yuan |
| description | The methanol extract from roots of Salacia hainanensis Chun et How afforded three new compounds, 24,26-dihydroxy-25-methoxy-tirucall-9-en-3-one (1), 2β,3β,22α-trihydroxy-lup-20(29)-ene (2) and 3β-hydroxy-2-carbonyl-lupan-29-oic acid (3), along with six known triterpenoids (4–9). Their structures were established on the basis of spectral analysis, in particular according to the data obtained by two-dimensional-NMR and high-resolution mass spectra experiments. Some of them showed much stronger inhibitory activity towards α-glucosidase than the positive control (acarbose, IC₅₀ 10.2 μM). |
| doi_str_mv | 10.1007/s11418-013-0744-5 |
| format | Article |
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Their structures were established on the basis of spectral analysis, in particular according to the data obtained by two-dimensional-NMR and high-resolution mass spectra experiments. Some of them showed much stronger inhibitory activity towards α-glucosidase than the positive control (acarbose, IC₅₀ 10.2 μM).</description><identifier>ISSN: 1340-3443</identifier><identifier>EISSN: 1861-0293</identifier><identifier>DOI: 10.1007/s11418-013-0744-5</identifier><identifier>PMID: 23361306</identifier><language>eng</language><publisher>Tokyo: Springer-Verlag</publisher><subject>acarbose ; alpha-glucosidase ; Biomedical and Life Sciences ; Biomedicine ; Complementary & Alternative Medicine ; Enzyme Inhibitors - chemistry ; Enzyme Inhibitors - pharmacology ; Glycoside Hydrolase Inhibitors ; inhibitory concentration 50 ; Medicinal Chemistry ; methanol ; Pharmacology/Toxicology ; Pharmacy ; Plant Roots - chemistry ; Plant Sciences ; roots ; Salacia - chemistry ; spectral analysis ; Triterpenes - chemistry ; Triterpenes - pharmacology ; triterpenoids</subject><ispartof>Journal of natural medicines, 2013-10, Vol.67 (4), p.844-849</ispartof><rights>The Japanese Society of Pharmacognosy and Springer Japan 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c392t-5fdb5bee4714823f0db6ac5d14367482ad9ea6afeff8fb709b299c6b4289df343</citedby><cites>FETCH-LOGICAL-c392t-5fdb5bee4714823f0db6ac5d14367482ad9ea6afeff8fb709b299c6b4289df343</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11418-013-0744-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11418-013-0744-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23361306$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Guo, Zheng-hong</creatorcontrib><creatorcontrib>Huang, Jian</creatorcontrib><creatorcontrib>Wan, Guo-sheng</creatorcontrib><creatorcontrib>Huo, Xiao-ling</creatorcontrib><creatorcontrib>Gao, Hui-Yuan</creatorcontrib><title>New inhibitors of α-glucosidase in Salacia hainanensis Chun et How</title><title>Journal of natural medicines</title><addtitle>J Nat Med</addtitle><addtitle>J Nat Med</addtitle><description>The methanol extract from roots of Salacia hainanensis Chun et How afforded three new compounds, 24,26-dihydroxy-25-methoxy-tirucall-9-en-3-one (1), 2β,3β,22α-trihydroxy-lup-20(29)-ene (2) and 3β-hydroxy-2-carbonyl-lupan-29-oic acid (3), along with six known triterpenoids (4–9). Their structures were established on the basis of spectral analysis, in particular according to the data obtained by two-dimensional-NMR and high-resolution mass spectra experiments. Some of them showed much stronger inhibitory activity towards α-glucosidase than the positive control (acarbose, IC₅₀ 10.2 μM).</description><subject>acarbose</subject><subject>alpha-glucosidase</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Complementary & Alternative Medicine</subject><subject>Enzyme Inhibitors - chemistry</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>Glycoside Hydrolase Inhibitors</subject><subject>inhibitory concentration 50</subject><subject>Medicinal Chemistry</subject><subject>methanol</subject><subject>Pharmacology/Toxicology</subject><subject>Pharmacy</subject><subject>Plant Roots - chemistry</subject><subject>Plant Sciences</subject><subject>roots</subject><subject>Salacia - chemistry</subject><subject>spectral analysis</subject><subject>Triterpenes - chemistry</subject><subject>Triterpenes - pharmacology</subject><subject>triterpenoids</subject><issn>1340-3443</issn><issn>1861-0293</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtOwzAQRS0EgvL4ADaQJRvDjO08vEQVL6mCBbC2nMRuXaUx2I0qPosf4ZtwFWDJakYz917NHEJOES4RoLyKiAIrCsgplELQfIdMsCqQApN8N_VcAOVC8ANyGOMSQDDOcZ8cpFIgh2JCpo9mk7l-4Wq39iFm3mZfn3TeDY2PrtXRpGX2rDvdOJ0ttOt1b_roYjZdDH1m1tm93xyTPau7aE5-6hF5vb15md7T2dPdw_R6Rhsu2Zrmtq3z2hhRoqgYt9DWhW7yFgUvyjTRrTS60NZYW9m6BFkzKZuiFqySreWCH5GLMfct-PfBxLVaudiYrks3-SGqFIRMCuAsSXGUNsHHGIxVb8GtdPhQCGrLTo3sVGKntuxUnjxnP_FDvTLtn-MXVhKwURDTqp-boJZ-CH16-d_U89FktVd6HlxUr88MUABgyWUu-De4r4LB</recordid><startdate>20131001</startdate><enddate>20131001</enddate><creator>Guo, Zheng-hong</creator><creator>Huang, Jian</creator><creator>Wan, Guo-sheng</creator><creator>Huo, Xiao-ling</creator><creator>Gao, Hui-Yuan</creator><general>Springer-Verlag</general><general>Springer Japan</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20131001</creationdate><title>New inhibitors of α-glucosidase in Salacia hainanensis Chun et How</title><author>Guo, Zheng-hong ; Huang, Jian ; Wan, Guo-sheng ; Huo, Xiao-ling ; Gao, Hui-Yuan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c392t-5fdb5bee4714823f0db6ac5d14367482ad9ea6afeff8fb709b299c6b4289df343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>acarbose</topic><topic>alpha-glucosidase</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Complementary & Alternative Medicine</topic><topic>Enzyme Inhibitors - chemistry</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>Glycoside Hydrolase Inhibitors</topic><topic>inhibitory concentration 50</topic><topic>Medicinal Chemistry</topic><topic>methanol</topic><topic>Pharmacology/Toxicology</topic><topic>Pharmacy</topic><topic>Plant Roots - chemistry</topic><topic>Plant Sciences</topic><topic>roots</topic><topic>Salacia - chemistry</topic><topic>spectral analysis</topic><topic>Triterpenes - chemistry</topic><topic>Triterpenes - pharmacology</topic><topic>triterpenoids</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Guo, Zheng-hong</creatorcontrib><creatorcontrib>Huang, Jian</creatorcontrib><creatorcontrib>Wan, Guo-sheng</creatorcontrib><creatorcontrib>Huo, Xiao-ling</creatorcontrib><creatorcontrib>Gao, Hui-Yuan</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of natural medicines</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Guo, Zheng-hong</au><au>Huang, Jian</au><au>Wan, Guo-sheng</au><au>Huo, Xiao-ling</au><au>Gao, Hui-Yuan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>New inhibitors of α-glucosidase in Salacia hainanensis Chun et How</atitle><jtitle>Journal of natural medicines</jtitle><stitle>J Nat Med</stitle><addtitle>J Nat Med</addtitle><date>2013-10-01</date><risdate>2013</risdate><volume>67</volume><issue>4</issue><spage>844</spage><epage>849</epage><pages>844-849</pages><issn>1340-3443</issn><eissn>1861-0293</eissn><abstract>The methanol extract from roots of Salacia hainanensis Chun et How afforded three new compounds, 24,26-dihydroxy-25-methoxy-tirucall-9-en-3-one (1), 2β,3β,22α-trihydroxy-lup-20(29)-ene (2) and 3β-hydroxy-2-carbonyl-lupan-29-oic acid (3), along with six known triterpenoids (4–9). Their structures were established on the basis of spectral analysis, in particular according to the data obtained by two-dimensional-NMR and high-resolution mass spectra experiments. Some of them showed much stronger inhibitory activity towards α-glucosidase than the positive control (acarbose, IC₅₀ 10.2 μM).</abstract><cop>Tokyo</cop><pub>Springer-Verlag</pub><pmid>23361306</pmid><doi>10.1007/s11418-013-0744-5</doi><tpages>6</tpages></addata></record> |
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| subjects | acarbose alpha-glucosidase Biomedical and Life Sciences Biomedicine Complementary & Alternative Medicine Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Glycoside Hydrolase Inhibitors inhibitory concentration 50 Medicinal Chemistry methanol Pharmacology/Toxicology Pharmacy Plant Roots - chemistry Plant Sciences roots Salacia - chemistry spectral analysis Triterpenes - chemistry Triterpenes - pharmacology triterpenoids |
| title | New inhibitors of α-glucosidase in Salacia hainanensis Chun et How |
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