First report of warfarin dose requirements in patients possessing the CYP2C912 allele

Warfarin is the most frequently prescribed anticoagulant in North America and Europe. It is administered as a racemate, but S-warfarin is principally responsible for its anticoagulant activity. Cytochrome P450 (CYP) 2C9 is the enzyme primarily responsible for the metabolism of S-warfarin. Numerous v...

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Veröffentlicht in:	Clinica chimica acta 2013-09, Vol.424, p.73-75
Hauptverfasser:	O'Brien, Travis J., Kidd, Robert S., Richard, Craig A.H., Ha, Ngoc-Han, Witcher, Preston, Tran, Linda V., Barbour, April, Tuck, Matthew, McIntosh, Samantha D., Douglas, Jacqueline N., Harralson, Arthur F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Alleles Amino Acid Substitution Anticoagulants - metabolism Anticoagulants - therapeutic use Apolipoproteins E - genetics Aryl Hydrocarbon Hydroxylases - genetics Aryl Hydrocarbon Hydroxylases - metabolism Base Sequence Biotransformation CYP2C9 CYP2C912 Cytochrome P-450 CYP2C9 Drug Dosage Calculations Female Genotype Genotyping Techniques Heterozygote Humans Male Middle Aged Molecular Sequence Data Mutation rs9332239 Thromboembolism - enzymology Thromboembolism - genetics Thromboembolism - pathology Thromboembolism - prevention & control Vitamin K Epoxide Reductases - genetics Warfarin Warfarin - metabolism Warfarin - therapeutic use
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