Effect of Immunosuppression on Neonatally Diethylstilbestrol-Induced Genital Tract Lesion and Tumor Development in Female Mice

Neonatal treatment of female rodents with the synthetic estrogen diethylstilbestrol [(DES) CAS: 56-53-1; α,α'-diethyl-4,4′-dimethoxystilbene] results in immunodeficiency that persists into adulthood, along with progressive development of genital tract lesions. DES-induced immunosuppression was...

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Veröffentlicht in:	JNCI : Journal of the National Cancer Institute 1984-10, Vol.73 (4), p.863-870
Hauptverfasser:	Ways, Susan C., Bern, Howard A., Blair, Phyllis B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal tumors. Experimental tumors Animals Animals, Newborn Biological and medical sciences diethylstilbestrol Diethylstilbestrol - toxicity Experimental genital and mammary tumors Female Genital Neoplasms, Female - chemically induced Genital Neoplasms, Female - immunology Genital Neoplasms, Female - pathology genital tract Immune Sera Immunosuppression Medical sciences Mice Mice, Inbred Strains Thymectomy Thymus Gland - immunology Tumors
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