Effects and Interactions of Natural Cannabinoids on the Isolated Heart
Abstract A Langendorff perfused rat heart preparation was designed to process dose-response effects of cardioactive drugs on rate, coronary flow, and supraaortic differential pressure (ΔP; an index of cardiac performance). In this preparation, Δ9--tetrahydrocannabinol (THC) 2 × 10-6 M to 10-5 M indu...
Gespeichert in:
| Veröffentlicht in: | Experimental biology and medicine (Maywood, N.J.) N.J.), 1985-11, Vol.180 (2), p.312-316 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 316 |
|---|---|
| container_issue | 2 |
| container_start_page | 312 |
| container_title | Experimental biology and medicine (Maywood, N.J.) |
| container_volume | 180 |
| creator | Nahas, Gabriel Trouve, Renaud |
| description | Abstract
A Langendorff perfused rat heart preparation was designed to process dose-response effects of cardioactive drugs on rate, coronary flow, and supraaortic differential pressure (ΔP; an index of cardiac performance). In this preparation, Δ9--tetrahydrocannabinol (THC) 2 × 10-6
M to 10-5
M induces in the isolated perfused rat heart a biphasic increase in rate (maximal at 8 × 10-6
M). Tachycardia is associated with decreases in (ΔP) and no change or decreased coronary flow. Cardiac toxicity is observed with 3 × 10-5
M. Cannabidiol (CBD) at concentrations of 9 × 10-6
M to 10-4
M has limited effect on rate while increasing ΔP and coronary flow. Cannabinol (CBN) 8 × 10-6
M to 3 × 10-4
M depresses rate and ΔP while coronary flow remains constant. Simultaneous equimolar administration of THC with CBD antagonizes or mitigates the cardiac effects of THC on rate, ΔP, and coronary flow. |
| doi_str_mv | 10.3181/00379727-180-42181 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_14308984</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.3181_00379727-180-42181</sage_id><sourcerecordid>14308984</sourcerecordid><originalsourceid>FETCH-LOGICAL-c398t-78ca2103e1d6cac97d2c21bacbd8549f0ddaac887c81cf6e38947353f016050e3</originalsourceid><addsrcrecordid>eNp9kD1PwzAQhi0EKqXwB5CQMiC2UDtOYntEVUsrVbDAbF38AalSp9jOwL_HpaUj00l3z_ue9CB0S_AjJZxMMaZMsILlhOO8LNLqDI1JRauc1kKco_EeyPfEJboKYYMxqVhRj9CoxCUntRijxdxao2LIwOls5aLxoGLbu5D1NnuBOHjoshk4B03r-lanvcvip8lWoe8gGp0tDfh4jS4sdMHcHOcEvS_mb7Nlvn59Xs2e1rmigseccQUFwdQQXStQgulCFaQB1WhelcJirQEU50xxomxtKBcloxW1mNS4woZO0MOhd-f7r8GEKLdtUKbrwJl-CJKUFHPBywQWB1D5PgRvrNz5dgv-WxIs9_LknzyZ5MlfeSl0d2wfmq3Rp8jRVrrfH-8QFHTWg1NtOGFM1KmnTtj0gAX4MHLTD94lJ_89_gFrPYOq</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>14308984</pqid></control><display><type>article</type><title>Effects and Interactions of Natural Cannabinoids on the Isolated Heart</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Nahas, Gabriel ; Trouve, Renaud</creator><creatorcontrib>Nahas, Gabriel ; Trouve, Renaud</creatorcontrib><description>Abstract
A Langendorff perfused rat heart preparation was designed to process dose-response effects of cardioactive drugs on rate, coronary flow, and supraaortic differential pressure (ΔP; an index of cardiac performance). In this preparation, Δ9--tetrahydrocannabinol (THC) 2 × 10-6
M to 10-5
M induces in the isolated perfused rat heart a biphasic increase in rate (maximal at 8 × 10-6
M). Tachycardia is associated with decreases in (ΔP) and no change or decreased coronary flow. Cardiac toxicity is observed with 3 × 10-5
M. Cannabidiol (CBD) at concentrations of 9 × 10-6
M to 10-4
M has limited effect on rate while increasing ΔP and coronary flow. Cannabinol (CBN) 8 × 10-6
M to 3 × 10-4
M depresses rate and ΔP while coronary flow remains constant. Simultaneous equimolar administration of THC with CBD antagonizes or mitigates the cardiac effects of THC on rate, ΔP, and coronary flow.</description><identifier>ISSN: 0037-9727</identifier><identifier>ISSN: 1535-3702</identifier><identifier>EISSN: 1535-3699</identifier><identifier>EISSN: 1525-1373</identifier><identifier>DOI: 10.3181/00379727-180-42181</identifier><identifier>PMID: 4048169</identifier><identifier>CODEN: PSEBAA</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Animals ; Biological and medical sciences ; Blood Pressure - drug effects ; Cannabidiol - pharmacology ; Cannabidiol - toxicity ; Cannabinoids - pharmacology ; Cannabinoids - toxicity ; Cannabinol - pharmacology ; Cannabinol - toxicity ; Cardiac Output - drug effects ; Coronary Circulation - drug effects ; Dose-Response Relationship, Drug ; Drug addictions ; Heart - drug effects ; Heart - physiopathology ; Heart Rate - drug effects ; Hemodynamics - drug effects ; Medical sciences ; Rats ; Rats, Inbred Strains ; Tachycardia - chemically induced ; Toxicology</subject><ispartof>Experimental biology and medicine (Maywood, N.J.), 1985-11, Vol.180 (2), p.312-316</ispartof><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c398t-78ca2103e1d6cac97d2c21bacbd8549f0ddaac887c81cf6e38947353f016050e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7964216$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4048169$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nahas, Gabriel</creatorcontrib><creatorcontrib>Trouve, Renaud</creatorcontrib><title>Effects and Interactions of Natural Cannabinoids on the Isolated Heart</title><title>Experimental biology and medicine (Maywood, N.J.)</title><addtitle>Proc Soc Exp Biol Med</addtitle><description>Abstract
A Langendorff perfused rat heart preparation was designed to process dose-response effects of cardioactive drugs on rate, coronary flow, and supraaortic differential pressure (ΔP; an index of cardiac performance). In this preparation, Δ9--tetrahydrocannabinol (THC) 2 × 10-6
M to 10-5
M induces in the isolated perfused rat heart a biphasic increase in rate (maximal at 8 × 10-6
M). Tachycardia is associated with decreases in (ΔP) and no change or decreased coronary flow. Cardiac toxicity is observed with 3 × 10-5
M. Cannabidiol (CBD) at concentrations of 9 × 10-6
M to 10-4
M has limited effect on rate while increasing ΔP and coronary flow. Cannabinol (CBN) 8 × 10-6
M to 3 × 10-4
M depresses rate and ΔP while coronary flow remains constant. Simultaneous equimolar administration of THC with CBD antagonizes or mitigates the cardiac effects of THC on rate, ΔP, and coronary flow.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>Cannabidiol - pharmacology</subject><subject>Cannabidiol - toxicity</subject><subject>Cannabinoids - pharmacology</subject><subject>Cannabinoids - toxicity</subject><subject>Cannabinol - pharmacology</subject><subject>Cannabinol - toxicity</subject><subject>Cardiac Output - drug effects</subject><subject>Coronary Circulation - drug effects</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug addictions</subject><subject>Heart - drug effects</subject><subject>Heart - physiopathology</subject><subject>Heart Rate - drug effects</subject><subject>Hemodynamics - drug effects</subject><subject>Medical sciences</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Tachycardia - chemically induced</subject><subject>Toxicology</subject><issn>0037-9727</issn><issn>1535-3702</issn><issn>1535-3699</issn><issn>1525-1373</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD1PwzAQhi0EKqXwB5CQMiC2UDtOYntEVUsrVbDAbF38AalSp9jOwL_HpaUj00l3z_ue9CB0S_AjJZxMMaZMsILlhOO8LNLqDI1JRauc1kKco_EeyPfEJboKYYMxqVhRj9CoxCUntRijxdxao2LIwOls5aLxoGLbu5D1NnuBOHjoshk4B03r-lanvcvip8lWoe8gGp0tDfh4jS4sdMHcHOcEvS_mb7Nlvn59Xs2e1rmigseccQUFwdQQXStQgulCFaQB1WhelcJirQEU50xxomxtKBcloxW1mNS4woZO0MOhd-f7r8GEKLdtUKbrwJl-CJKUFHPBywQWB1D5PgRvrNz5dgv-WxIs9_LknzyZ5MlfeSl0d2wfmq3Rp8jRVrrfH-8QFHTWg1NtOGFM1KmnTtj0gAX4MHLTD94lJ_89_gFrPYOq</recordid><startdate>198511</startdate><enddate>198511</enddate><creator>Nahas, Gabriel</creator><creator>Trouve, Renaud</creator><general>SAGE Publications</general><general>Blackwell Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>198511</creationdate><title>Effects and Interactions of Natural Cannabinoids on the Isolated Heart</title><author>Nahas, Gabriel ; Trouve, Renaud</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c398t-78ca2103e1d6cac97d2c21bacbd8549f0ddaac887c81cf6e38947353f016050e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure - drug effects</topic><topic>Cannabidiol - pharmacology</topic><topic>Cannabidiol - toxicity</topic><topic>Cannabinoids - pharmacology</topic><topic>Cannabinoids - toxicity</topic><topic>Cannabinol - pharmacology</topic><topic>Cannabinol - toxicity</topic><topic>Cardiac Output - drug effects</topic><topic>Coronary Circulation - drug effects</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug addictions</topic><topic>Heart - drug effects</topic><topic>Heart - physiopathology</topic><topic>Heart Rate - drug effects</topic><topic>Hemodynamics - drug effects</topic><topic>Medical sciences</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Tachycardia - chemically induced</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nahas, Gabriel</creatorcontrib><creatorcontrib>Trouve, Renaud</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nahas, Gabriel</au><au>Trouve, Renaud</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects and Interactions of Natural Cannabinoids on the Isolated Heart</atitle><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle><addtitle>Proc Soc Exp Biol Med</addtitle><date>1985-11</date><risdate>1985</risdate><volume>180</volume><issue>2</issue><spage>312</spage><epage>316</epage><pages>312-316</pages><issn>0037-9727</issn><issn>1535-3702</issn><eissn>1535-3699</eissn><eissn>1525-1373</eissn><coden>PSEBAA</coden><abstract>Abstract
A Langendorff perfused rat heart preparation was designed to process dose-response effects of cardioactive drugs on rate, coronary flow, and supraaortic differential pressure (ΔP; an index of cardiac performance). In this preparation, Δ9--tetrahydrocannabinol (THC) 2 × 10-6
M to 10-5
M induces in the isolated perfused rat heart a biphasic increase in rate (maximal at 8 × 10-6
M). Tachycardia is associated with decreases in (ΔP) and no change or decreased coronary flow. Cardiac toxicity is observed with 3 × 10-5
M. Cannabidiol (CBD) at concentrations of 9 × 10-6
M to 10-4
M has limited effect on rate while increasing ΔP and coronary flow. Cannabinol (CBN) 8 × 10-6
M to 3 × 10-4
M depresses rate and ΔP while coronary flow remains constant. Simultaneous equimolar administration of THC with CBD antagonizes or mitigates the cardiac effects of THC on rate, ΔP, and coronary flow.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>4048169</pmid><doi>10.3181/00379727-180-42181</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0037-9727 |
| ispartof | Experimental biology and medicine (Maywood, N.J.), 1985-11, Vol.180 (2), p.312-316 |
| issn | 0037-9727 1535-3702 1535-3699 1525-1373 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_14308984 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Biological and medical sciences Blood Pressure - drug effects Cannabidiol - pharmacology Cannabidiol - toxicity Cannabinoids - pharmacology Cannabinoids - toxicity Cannabinol - pharmacology Cannabinol - toxicity Cardiac Output - drug effects Coronary Circulation - drug effects Dose-Response Relationship, Drug Drug addictions Heart - drug effects Heart - physiopathology Heart Rate - drug effects Hemodynamics - drug effects Medical sciences Rats Rats, Inbred Strains Tachycardia - chemically induced Toxicology |
| title | Effects and Interactions of Natural Cannabinoids on the Isolated Heart |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T13%3A29%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20and%20Interactions%20of%20Natural%20Cannabinoids%20on%20the%20Isolated%20Heart&rft.jtitle=Experimental%20biology%20and%20medicine%20(Maywood,%20N.J.)&rft.au=Nahas,%20Gabriel&rft.date=1985-11&rft.volume=180&rft.issue=2&rft.spage=312&rft.epage=316&rft.pages=312-316&rft.issn=0037-9727&rft.eissn=1535-3699&rft.coden=PSEBAA&rft_id=info:doi/10.3181/00379727-180-42181&rft_dat=%3Cproquest_cross%3E14308984%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=14308984&rft_id=info:pmid/4048169&rft_sage_id=10.3181_00379727-180-42181&rfr_iscdi=true |