Efficacy and safety of collagen matrix implants in phacotrabeculectomy and comparison with mitomycin C augmented phacotrabeculectomy at 1 year
Background To assess the efficacy and safety of collagen matrix implant (Ologen) in phacotrabeculectomy. Design Prospective, non‐randomized, comparative study. Participants Sixty‐six Asian patients. Methods Thirty three consecutive patients underwent phacotrabeculectomy with Ologen implant and intra...
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| Veröffentlicht in: | Clinical & experimental ophthalmology 2013-08, Vol.41 (6), p.552-560 |
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| creator | Narayanaswamy, Arun Perera, Shamira A Htoon, Hla M Hoh, Sek-Tien Seah, Steve K Wong, Tina T Aung, Tin |
| description | Background
To assess the efficacy and safety of collagen matrix implant (Ologen) in phacotrabeculectomy.
Design
Prospective, non‐randomized, comparative study.
Participants
Sixty‐six Asian patients.
Methods
Thirty three consecutive patients underwent phacotrabeculectomy with Ologen implant and intraocular lens implantation, and 33 subjects recruited as controls underwent surgery with mitomycin C augmentation.
Main Outcome Measures
The primary outcome measure was postoperative intraocular pressure at month 12. Additional postoperative treatments, such as bleb needling, and adverse events were secondary outcomes.
Results
The overall percentage reduction in intraocular pressure was 13% (95% confidence interval 6.7–19.2) in the Ologen group and 26% (95% confidence interval 14.8–37.9) in the mitomycin C group (P = 0.05). At 1 year after surgery (after adjusting for baseline differences), intraocular pressure decreased by 4.2 mmHg (95% confidence interval 2.8–5.6 mmHg) and 5.6 mmHg (95% confidence interval 4.2–7.0 mmHg), respectively (P = 0.16). Needling with 5‐fluorouracil was required more often in the Ologen group (39% vs. 6%; P = 0.003). There was similar frequency ( |
| doi_str_mv | 10.1111/ceo.12058 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1430862884</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3032355231</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4248-21b11f3c147773769c09e30cc86fb877228f2fcc488cbbe3c38a6821e1d1dddc3</originalsourceid><addsrcrecordid>eNqNkc1u1DAURiMEoqWw4AWQJTawSOu_xM4SDcMUqaIbUJeWc2O3LkkcbEdtXoJnxkOmXSCQ8MaWfM4n3fsVxWuCT0k-Z2D8KaG4kk-KY8I5LRssyNPDu-aYHxUvYrzFGFeU1c-LI8qoaGosjoufW2sdaFiQHjsUtTVpQd4i8H2vr82IBp2Cu0dumHo9pojciKYbDT4F3RqYewPJD6sNfph0cNGP6M6lGzS4_RdkY4P0fD2YMZnu73ZCBC1Gh5fFM6v7aF4d7pPi26ft1815eXG5-7z5cFECp1yWlLSEWAaECyGYqBvAjWEYQNa2lUJQKi21AFxKaFvDgEldS0oM6UjXdcBOindr7hT8j9nEpAYXweSZR-PnqAhnWNZUSv4fKBEVo3XFMvr2D_TWz2HMg-ypqhJCSpKp9ysFwccYjFVTcIMOiyJY7ftUuU_1u8_Mvjkkzu1gukfyocAMnK3AnevN8u8ktdlePkSWq-FiMvePhg7fVZ13WamrLzt19fGcV6Jp1I79Ao4kugs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1415577881</pqid></control><display><type>article</type><title>Efficacy and safety of collagen matrix implants in phacotrabeculectomy and comparison with mitomycin C augmented phacotrabeculectomy at 1 year</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><creator>Narayanaswamy, Arun ; Perera, Shamira A ; Htoon, Hla M ; Hoh, Sek-Tien ; Seah, Steve K ; Wong, Tina T ; Aung, Tin</creator><creatorcontrib>Narayanaswamy, Arun ; Perera, Shamira A ; Htoon, Hla M ; Hoh, Sek-Tien ; Seah, Steve K ; Wong, Tina T ; Aung, Tin</creatorcontrib><description>Background
To assess the efficacy and safety of collagen matrix implant (Ologen) in phacotrabeculectomy.
Design
Prospective, non‐randomized, comparative study.
Participants
Sixty‐six Asian patients.
Methods
Thirty three consecutive patients underwent phacotrabeculectomy with Ologen implant and intraocular lens implantation, and 33 subjects recruited as controls underwent surgery with mitomycin C augmentation.
Main Outcome Measures
The primary outcome measure was postoperative intraocular pressure at month 12. Additional postoperative treatments, such as bleb needling, and adverse events were secondary outcomes.
Results
The overall percentage reduction in intraocular pressure was 13% (95% confidence interval 6.7–19.2) in the Ologen group and 26% (95% confidence interval 14.8–37.9) in the mitomycin C group (P = 0.05). At 1 year after surgery (after adjusting for baseline differences), intraocular pressure decreased by 4.2 mmHg (95% confidence interval 2.8–5.6 mmHg) and 5.6 mmHg (95% confidence interval 4.2–7.0 mmHg), respectively (P = 0.16). Needling with 5‐fluorouracil was required more often in the Ologen group (39% vs. 6%; P = 0.003). There was similar frequency (<10%) of adverse events in both groups, and there were no complications directly related to the Ologen implant. The blebs in the mitomycin C group had greater central area (P = 0.005), maximal area (P = 0.01) and height (P = 0.005), and were less vascular (P = 0.023) than the Ologen blebs.
Conclusions
At 1 year, the overall performance of Ologen in combined phacotrabeculectomy was suboptimal compared with combined surgery with mitomycin C. Eyes in the Ologen group required more frequent bleb needling procedures.</description><identifier>ISSN: 1442-6404</identifier><identifier>EISSN: 1442-9071</identifier><identifier>DOI: 10.1111/ceo.12058</identifier><identifier>PMID: 23279607</identifier><language>eng</language><publisher>Australia: Blackwell Publishing Ltd</publisher><subject>Absorbable Implants ; Aged ; Alkylating Agents - therapeutic use ; Cataract - complications ; Cataract - physiopathology ; Cataract - therapy ; Collagen ; collagen implant ; Confidence intervals ; Female ; Glaucoma ; Glaucoma - complications ; Glaucoma - physiopathology ; Glaucoma - surgery ; Glycosaminoglycans ; Humans ; Intraocular Pressure - physiology ; Lens Implantation, Intraocular ; Male ; Mitomycin - therapeutic use ; Ologen ; Phacoemulsification - methods ; Polymers ; Prospective Studies ; Surgery ; Trabeculectomy - methods ; Treatment Outcome ; Visual Acuity - physiology ; wound healing</subject><ispartof>Clinical & experimental ophthalmology, 2013-08, Vol.41 (6), p.552-560</ispartof><rights>2012 The Authors. Clinical and Experimental Ophthalmology © 2012 Royal Australian and New Zealand College of Ophthalmologists</rights><rights>2012 The Authors. Clinical and Experimental Ophthalmology © 2012 Royal Australian and New Zealand College of Ophthalmologists.</rights><rights>Clinical and Experimental Ophthalmology © 2013 Royal Australian and New Zealand College of Ophthalmologists</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4248-21b11f3c147773769c09e30cc86fb877228f2fcc488cbbe3c38a6821e1d1dddc3</citedby><cites>FETCH-LOGICAL-c4248-21b11f3c147773769c09e30cc86fb877228f2fcc488cbbe3c38a6821e1d1dddc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fceo.12058$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fceo.12058$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23279607$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Narayanaswamy, Arun</creatorcontrib><creatorcontrib>Perera, Shamira A</creatorcontrib><creatorcontrib>Htoon, Hla M</creatorcontrib><creatorcontrib>Hoh, Sek-Tien</creatorcontrib><creatorcontrib>Seah, Steve K</creatorcontrib><creatorcontrib>Wong, Tina T</creatorcontrib><creatorcontrib>Aung, Tin</creatorcontrib><title>Efficacy and safety of collagen matrix implants in phacotrabeculectomy and comparison with mitomycin C augmented phacotrabeculectomy at 1 year</title><title>Clinical & experimental ophthalmology</title><addtitle>Clin Experiment Ophthalmol</addtitle><description>Background
To assess the efficacy and safety of collagen matrix implant (Ologen) in phacotrabeculectomy.
Design
Prospective, non‐randomized, comparative study.
Participants
Sixty‐six Asian patients.
Methods
Thirty three consecutive patients underwent phacotrabeculectomy with Ologen implant and intraocular lens implantation, and 33 subjects recruited as controls underwent surgery with mitomycin C augmentation.
Main Outcome Measures
The primary outcome measure was postoperative intraocular pressure at month 12. Additional postoperative treatments, such as bleb needling, and adverse events were secondary outcomes.
Results
The overall percentage reduction in intraocular pressure was 13% (95% confidence interval 6.7–19.2) in the Ologen group and 26% (95% confidence interval 14.8–37.9) in the mitomycin C group (P = 0.05). At 1 year after surgery (after adjusting for baseline differences), intraocular pressure decreased by 4.2 mmHg (95% confidence interval 2.8–5.6 mmHg) and 5.6 mmHg (95% confidence interval 4.2–7.0 mmHg), respectively (P = 0.16). Needling with 5‐fluorouracil was required more often in the Ologen group (39% vs. 6%; P = 0.003). There was similar frequency (<10%) of adverse events in both groups, and there were no complications directly related to the Ologen implant. The blebs in the mitomycin C group had greater central area (P = 0.005), maximal area (P = 0.01) and height (P = 0.005), and were less vascular (P = 0.023) than the Ologen blebs.
Conclusions
At 1 year, the overall performance of Ologen in combined phacotrabeculectomy was suboptimal compared with combined surgery with mitomycin C. Eyes in the Ologen group required more frequent bleb needling procedures.</description><subject>Absorbable Implants</subject><subject>Aged</subject><subject>Alkylating Agents - therapeutic use</subject><subject>Cataract - complications</subject><subject>Cataract - physiopathology</subject><subject>Cataract - therapy</subject><subject>Collagen</subject><subject>collagen implant</subject><subject>Confidence intervals</subject><subject>Female</subject><subject>Glaucoma</subject><subject>Glaucoma - complications</subject><subject>Glaucoma - physiopathology</subject><subject>Glaucoma - surgery</subject><subject>Glycosaminoglycans</subject><subject>Humans</subject><subject>Intraocular Pressure - physiology</subject><subject>Lens Implantation, Intraocular</subject><subject>Male</subject><subject>Mitomycin - therapeutic use</subject><subject>Ologen</subject><subject>Phacoemulsification - methods</subject><subject>Polymers</subject><subject>Prospective Studies</subject><subject>Surgery</subject><subject>Trabeculectomy - methods</subject><subject>Treatment Outcome</subject><subject>Visual Acuity - physiology</subject><subject>wound healing</subject><issn>1442-6404</issn><issn>1442-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1u1DAURiMEoqWw4AWQJTawSOu_xM4SDcMUqaIbUJeWc2O3LkkcbEdtXoJnxkOmXSCQ8MaWfM4n3fsVxWuCT0k-Z2D8KaG4kk-KY8I5LRssyNPDu-aYHxUvYrzFGFeU1c-LI8qoaGosjoufW2sdaFiQHjsUtTVpQd4i8H2vr82IBp2Cu0dumHo9pojciKYbDT4F3RqYewPJD6sNfph0cNGP6M6lGzS4_RdkY4P0fD2YMZnu73ZCBC1Gh5fFM6v7aF4d7pPi26ft1815eXG5-7z5cFECp1yWlLSEWAaECyGYqBvAjWEYQNa2lUJQKi21AFxKaFvDgEldS0oM6UjXdcBOindr7hT8j9nEpAYXweSZR-PnqAhnWNZUSv4fKBEVo3XFMvr2D_TWz2HMg-ypqhJCSpKp9ysFwccYjFVTcIMOiyJY7ftUuU_1u8_Mvjkkzu1gukfyocAMnK3AnevN8u8ktdlePkSWq-FiMvePhg7fVZ13WamrLzt19fGcV6Jp1I79Ao4kugs</recordid><startdate>201308</startdate><enddate>201308</enddate><creator>Narayanaswamy, Arun</creator><creator>Perera, Shamira A</creator><creator>Htoon, Hla M</creator><creator>Hoh, Sek-Tien</creator><creator>Seah, Steve K</creator><creator>Wong, Tina T</creator><creator>Aung, Tin</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>201308</creationdate><title>Efficacy and safety of collagen matrix implants in phacotrabeculectomy and comparison with mitomycin C augmented phacotrabeculectomy at 1 year</title><author>Narayanaswamy, Arun ; Perera, Shamira A ; Htoon, Hla M ; Hoh, Sek-Tien ; Seah, Steve K ; Wong, Tina T ; Aung, Tin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4248-21b11f3c147773769c09e30cc86fb877228f2fcc488cbbe3c38a6821e1d1dddc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Absorbable Implants</topic><topic>Aged</topic><topic>Alkylating Agents - therapeutic use</topic><topic>Cataract - complications</topic><topic>Cataract - physiopathology</topic><topic>Cataract - therapy</topic><topic>Collagen</topic><topic>collagen implant</topic><topic>Confidence intervals</topic><topic>Female</topic><topic>Glaucoma</topic><topic>Glaucoma - complications</topic><topic>Glaucoma - physiopathology</topic><topic>Glaucoma - surgery</topic><topic>Glycosaminoglycans</topic><topic>Humans</topic><topic>Intraocular Pressure - physiology</topic><topic>Lens Implantation, Intraocular</topic><topic>Male</topic><topic>Mitomycin - therapeutic use</topic><topic>Ologen</topic><topic>Phacoemulsification - methods</topic><topic>Polymers</topic><topic>Prospective Studies</topic><topic>Surgery</topic><topic>Trabeculectomy - methods</topic><topic>Treatment Outcome</topic><topic>Visual Acuity - physiology</topic><topic>wound healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Narayanaswamy, Arun</creatorcontrib><creatorcontrib>Perera, Shamira A</creatorcontrib><creatorcontrib>Htoon, Hla M</creatorcontrib><creatorcontrib>Hoh, Sek-Tien</creatorcontrib><creatorcontrib>Seah, Steve K</creatorcontrib><creatorcontrib>Wong, Tina T</creatorcontrib><creatorcontrib>Aung, Tin</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Clinical & experimental ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Narayanaswamy, Arun</au><au>Perera, Shamira A</au><au>Htoon, Hla M</au><au>Hoh, Sek-Tien</au><au>Seah, Steve K</au><au>Wong, Tina T</au><au>Aung, Tin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficacy and safety of collagen matrix implants in phacotrabeculectomy and comparison with mitomycin C augmented phacotrabeculectomy at 1 year</atitle><jtitle>Clinical & experimental ophthalmology</jtitle><addtitle>Clin Experiment Ophthalmol</addtitle><date>2013-08</date><risdate>2013</risdate><volume>41</volume><issue>6</issue><spage>552</spage><epage>560</epage><pages>552-560</pages><issn>1442-6404</issn><eissn>1442-9071</eissn><abstract>Background
To assess the efficacy and safety of collagen matrix implant (Ologen) in phacotrabeculectomy.
Design
Prospective, non‐randomized, comparative study.
Participants
Sixty‐six Asian patients.
Methods
Thirty three consecutive patients underwent phacotrabeculectomy with Ologen implant and intraocular lens implantation, and 33 subjects recruited as controls underwent surgery with mitomycin C augmentation.
Main Outcome Measures
The primary outcome measure was postoperative intraocular pressure at month 12. Additional postoperative treatments, such as bleb needling, and adverse events were secondary outcomes.
Results
The overall percentage reduction in intraocular pressure was 13% (95% confidence interval 6.7–19.2) in the Ologen group and 26% (95% confidence interval 14.8–37.9) in the mitomycin C group (P = 0.05). At 1 year after surgery (after adjusting for baseline differences), intraocular pressure decreased by 4.2 mmHg (95% confidence interval 2.8–5.6 mmHg) and 5.6 mmHg (95% confidence interval 4.2–7.0 mmHg), respectively (P = 0.16). Needling with 5‐fluorouracil was required more often in the Ologen group (39% vs. 6%; P = 0.003). There was similar frequency (<10%) of adverse events in both groups, and there were no complications directly related to the Ologen implant. The blebs in the mitomycin C group had greater central area (P = 0.005), maximal area (P = 0.01) and height (P = 0.005), and were less vascular (P = 0.023) than the Ologen blebs.
Conclusions
At 1 year, the overall performance of Ologen in combined phacotrabeculectomy was suboptimal compared with combined surgery with mitomycin C. Eyes in the Ologen group required more frequent bleb needling procedures.</abstract><cop>Australia</cop><pub>Blackwell Publishing Ltd</pub><pmid>23279607</pmid><doi>10.1111/ceo.12058</doi><tpages>9</tpages></addata></record> |
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| ispartof | Clinical & experimental ophthalmology, 2013-08, Vol.41 (6), p.552-560 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Absorbable Implants Aged Alkylating Agents - therapeutic use Cataract - complications Cataract - physiopathology Cataract - therapy Collagen collagen implant Confidence intervals Female Glaucoma Glaucoma - complications Glaucoma - physiopathology Glaucoma - surgery Glycosaminoglycans Humans Intraocular Pressure - physiology Lens Implantation, Intraocular Male Mitomycin - therapeutic use Ologen Phacoemulsification - methods Polymers Prospective Studies Surgery Trabeculectomy - methods Treatment Outcome Visual Acuity - physiology wound healing |
| title | Efficacy and safety of collagen matrix implants in phacotrabeculectomy and comparison with mitomycin C augmented phacotrabeculectomy at 1 year |
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