Expression of Human Gaucher Disease Gene GBA Generates Neurodevelopmental Defects and ER Stress in Drosophila Eye. e69147

Gaucher disease (GD) is the most common of the lysosomal storage disorders and is caused by defects in the GBA gene encoding glucocerebrosidase (GlcCerase). The accumulation of its substrate, glucocylceramide (GlcCer) is considered the main cause of GD. We found here that the expression of human mut...

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Veröffentlicht in:	PloS one 2013-08, Vol.8 (8)
Hauptverfasser:	Suzuki, Takahiro, Shimoda, Masami, Ito, Kumpei, Hanai, Shuji, Aizawa, Hidenobu, Kato, Tomoki, Kawasaki, Kazunori, Yamaguchi, Terumi, Ryoo, Hyung Don, Goto-Inoue, Naoko
Format:	Artikel
Sprache:	eng
Schlagworte:	Chaperones Drosophila
Online-Zugang:	Volltext
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