Comparative Analysis of the Expression of Neural Stem Cell-Associated Genes during Neocortex and Retina Development in Human
We compared the expression of Sox2, Oct4, Nanog, Pax6, Prox1 genes associated with plasticity of neural stem and progenitor cells during human neocortex and retina development and in cell cultures. At the analyzed stages of neurogenesis, Pax6 gene is expressed in the neocortex and retina at constant...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2013-02, Vol.154 (4), p.529-536 |
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| container_title | Bulletin of experimental biology and medicine |
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| creator | Verdiev, B. I. Milyushina, L. A. Podgornyi, O. V. Poltavtseva, R. A. Zinov’eva, R. D. Sukhikh, G. T. Aleksandrova, M. A. |
| description | We compared the expression of
Sox2, Oct4, Nanog, Pax6, Prox1
genes associated with plasticity of neural stem and progenitor cells during human neocortex and retina development and in cell cultures. At the analyzed stages of neurogenesis,
Pax6
gene is expressed in the neocortex and retina at constant levels, the expression is by one order of magnitude higher in the retina. The dynamics of
Sox2
and
Pax6
expression in the neocortex was similar. The expression of
Oct4
and
Nanog
genes during neurogenesis in the neocortex and human fetal retina reflects the existence of a high-plasticity cell pool. The dynamics of
βIII-tubulin
expression indicates that the retina develops more rapidly than the neocortex. Our experiments showed that genetically determined cell potencies typical of native cells are realized in primary cultures without specific stimulation. |
| doi_str_mv | 10.1007/s10517-013-1994-7 |
| format | Article |
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Sox2, Oct4, Nanog, Pax6, Prox1
genes associated with plasticity of neural stem and progenitor cells during human neocortex and retina development and in cell cultures. At the analyzed stages of neurogenesis,
Pax6
gene is expressed in the neocortex and retina at constant levels, the expression is by one order of magnitude higher in the retina. The dynamics of
Sox2
and
Pax6
expression in the neocortex was similar. The expression of
Oct4
and
Nanog
genes during neurogenesis in the neocortex and human fetal retina reflects the existence of a high-plasticity cell pool. The dynamics of
βIII-tubulin
expression indicates that the retina develops more rapidly than the neocortex. Our experiments showed that genetically determined cell potencies typical of native cells are realized in primary cultures without specific stimulation.</description><identifier>ISSN: 0007-4888</identifier><identifier>EISSN: 1573-8221</identifier><identifier>DOI: 10.1007/s10517-013-1994-7</identifier><identifier>PMID: 23486598</identifier><identifier>CODEN: BEXBAN</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Analysis ; Biomedical and Life Sciences ; Biomedicine ; Cell Biology ; Cell culture ; Cells, Cultured ; Eye Proteins - metabolism ; Genes ; Homeodomain Proteins - metabolism ; Humans ; Internal Medicine ; Laboratory Medicine ; Nanog Homeobox Protein ; Neocortex - metabolism ; Neural Stem Cells - metabolism ; Octamer Transcription Factor-3 - metabolism ; Paired Box Transcription Factors - metabolism ; Pathology ; PAX6 Transcription Factor ; Repressor Proteins - metabolism ; Retina - metabolism ; SOXB1 Transcription Factors - metabolism ; Stem cells ; Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine) ; Tumor Suppressor Proteins - metabolism</subject><ispartof>Bulletin of experimental biology and medicine, 2013-02, Vol.154 (4), p.529-536</ispartof><rights>Springer Science+Business Media New York 2013</rights><rights>COPYRIGHT 2013 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c503t-72e753d84807f1ee5ae601790229f6dfc6db253f93b0754c9ae3f743ddb1f63f3</citedby><cites>FETCH-LOGICAL-c503t-72e753d84807f1ee5ae601790229f6dfc6db253f93b0754c9ae3f743ddb1f63f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10517-013-1994-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10517-013-1994-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23486598$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Verdiev, B. I.</creatorcontrib><creatorcontrib>Milyushina, L. A.</creatorcontrib><creatorcontrib>Podgornyi, O. V.</creatorcontrib><creatorcontrib>Poltavtseva, R. A.</creatorcontrib><creatorcontrib>Zinov’eva, R. D.</creatorcontrib><creatorcontrib>Sukhikh, G. T.</creatorcontrib><creatorcontrib>Aleksandrova, M. A.</creatorcontrib><title>Comparative Analysis of the Expression of Neural Stem Cell-Associated Genes during Neocortex and Retina Development in Human</title><title>Bulletin of experimental biology and medicine</title><addtitle>Bull Exp Biol Med</addtitle><addtitle>Bull Exp Biol Med</addtitle><description>We compared the expression of
Sox2, Oct4, Nanog, Pax6, Prox1
genes associated with plasticity of neural stem and progenitor cells during human neocortex and retina development and in cell cultures. At the analyzed stages of neurogenesis,
Pax6
gene is expressed in the neocortex and retina at constant levels, the expression is by one order of magnitude higher in the retina. The dynamics of
Sox2
and
Pax6
expression in the neocortex was similar. The expression of
Oct4
and
Nanog
genes during neurogenesis in the neocortex and human fetal retina reflects the existence of a high-plasticity cell pool. The dynamics of
βIII-tubulin
expression indicates that the retina develops more rapidly than the neocortex. Our experiments showed that genetically determined cell potencies typical of native cells are realized in primary cultures without specific stimulation.</description><subject>Analysis</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Biology</subject><subject>Cell culture</subject><subject>Cells, Cultured</subject><subject>Eye Proteins - metabolism</subject><subject>Genes</subject><subject>Homeodomain Proteins - metabolism</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Laboratory Medicine</subject><subject>Nanog Homeobox Protein</subject><subject>Neocortex - metabolism</subject><subject>Neural Stem Cells - metabolism</subject><subject>Octamer Transcription Factor-3 - metabolism</subject><subject>Paired Box Transcription Factors - metabolism</subject><subject>Pathology</subject><subject>PAX6 Transcription Factor</subject><subject>Repressor Proteins - metabolism</subject><subject>Retina - metabolism</subject><subject>SOXB1 Transcription Factors - metabolism</subject><subject>Stem cells</subject><subject>Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)</subject><subject>Tumor Suppressor Proteins - metabolism</subject><issn>0007-4888</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkt1rFDEUxQdR7Fr9A3yRgCB9mZqbzEwyj8vaD6Eo-PEcsjM33ZSZZEwypQX_eDNs1VYUyUPI5XcOnNxTFC-BHgOl4m0EWoMoKfAS2rYqxaNiBbXgpWQMHhcrmqGyklIeFM9ivFqetIGnxQHjlWzqVq6K7xs_TjroZK-RrJ0ebqONxBuSdkhObqaAMVrvlskHnIMeyOeEI9ngMJTrGH1ndcKenKHDSPo5WHeZQd_5kPCGaNeTT5is0-QdXuPgpxFdItaR83nU7nnxxOgh4ou7-7D4enryZXNeXnw8e79ZX5RdTXkqBUNR815WkgoDiLXGhoJoKWOtaXrTNf2W1dy0fEtFXXWtRm5Exft-C6bhhh8WR3vfKfhvM8akRhu7HEE79HNUUHEqG9aw9v8oB1HRRgJk9PUf6JWfQ_7CxRB4RTm07Dd1qQdU1hmfgu4WU7XmXFIuQSxex3-h8ulxtJ13aGyePxC8uSfYoR7SLvphTnlZ8SEIe7ALPsaARk3BjjrcKqBqaZHat0jlFqmlRUpkzau7ZPN2xP6X4mdtMsD2QJyWjWO4F_2frj8A15vPMg</recordid><startdate>20130201</startdate><enddate>20130201</enddate><creator>Verdiev, B. 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I. ; Milyushina, L. A. ; Podgornyi, O. V. ; Poltavtseva, R. A. ; Zinov’eva, R. D. ; Sukhikh, G. T. ; Aleksandrova, M. 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I.</au><au>Milyushina, L. A.</au><au>Podgornyi, O. V.</au><au>Poltavtseva, R. A.</au><au>Zinov’eva, R. D.</au><au>Sukhikh, G. T.</au><au>Aleksandrova, M. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparative Analysis of the Expression of Neural Stem Cell-Associated Genes during Neocortex and Retina Development in Human</atitle><jtitle>Bulletin of experimental biology and medicine</jtitle><stitle>Bull Exp Biol Med</stitle><addtitle>Bull Exp Biol Med</addtitle><date>2013-02-01</date><risdate>2013</risdate><volume>154</volume><issue>4</issue><spage>529</spage><epage>536</epage><pages>529-536</pages><issn>0007-4888</issn><eissn>1573-8221</eissn><coden>BEXBAN</coden><abstract>We compared the expression of
Sox2, Oct4, Nanog, Pax6, Prox1
genes associated with plasticity of neural stem and progenitor cells during human neocortex and retina development and in cell cultures. At the analyzed stages of neurogenesis,
Pax6
gene is expressed in the neocortex and retina at constant levels, the expression is by one order of magnitude higher in the retina. The dynamics of
Sox2
and
Pax6
expression in the neocortex was similar. The expression of
Oct4
and
Nanog
genes during neurogenesis in the neocortex and human fetal retina reflects the existence of a high-plasticity cell pool. The dynamics of
βIII-tubulin
expression indicates that the retina develops more rapidly than the neocortex. Our experiments showed that genetically determined cell potencies typical of native cells are realized in primary cultures without specific stimulation.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>23486598</pmid><doi>10.1007/s10517-013-1994-7</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-4888 |
| ispartof | Bulletin of experimental biology and medicine, 2013-02, Vol.154 (4), p.529-536 |
| issn | 0007-4888 1573-8221 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Analysis Biomedical and Life Sciences Biomedicine Cell Biology Cell culture Cells, Cultured Eye Proteins - metabolism Genes Homeodomain Proteins - metabolism Humans Internal Medicine Laboratory Medicine Nanog Homeobox Protein Neocortex - metabolism Neural Stem Cells - metabolism Octamer Transcription Factor-3 - metabolism Paired Box Transcription Factors - metabolism Pathology PAX6 Transcription Factor Repressor Proteins - metabolism Retina - metabolism SOXB1 Transcription Factors - metabolism Stem cells Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine) Tumor Suppressor Proteins - metabolism |
| title | Comparative Analysis of the Expression of Neural Stem Cell-Associated Genes during Neocortex and Retina Development in Human |
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