Virological Efficacy in Cerebrospinal Fluid and Neurocognitive Status in Patients with Long-Term Monotherapy Based on Lopinavir/Ritonavir: An Exploratory Study. e70201

Virological Efficacy in Cerebrospinal Fluid and Neurocognitive Status in Patients with Long-Term Monotherapy Based on Lopinavir/Ritonavir: An Exploratory Study. e70201

Background Data on suppression of HIV replication in the CNS and on the subsequent risk of neurocognitive impairment using monotherapy with boosted protease inhibitors are limited. Methods Ours was an exploratory cross-sectional study in patients on lopinavir/ritonavir-based monotherapy (LPV/r-MT) o...

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Veröffentlicht in:PloS one 2013-07, Vol.8 (7)
Hauptverfasser: Santos, Jose R, Munoz-Moreno, Jose A, Molto, Jose, Prats, Anna, Curran, Adria, Domingo, Pere, Llibre, Josep M, McClernon, Daniel R, Bravo, Isabel, Canet, Jaume
Format: Artikel
Sprache:eng
Schlagworte:
Central nervous system
Human immunodeficiency virus 1
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Zusammenfassung:Background Data on suppression of HIV replication in the CNS and on the subsequent risk of neurocognitive impairment using monotherapy with boosted protease inhibitors are limited. Methods Ours was an exploratory cross-sectional study in patients on lopinavir/ritonavir-based monotherapy (LPV/r-MT) or standard triple therapy (LPV/r-ART) for at least 96 weeks who maintained a plasma viral load
ISSN:1932-6203
DOI:10.1371/journal.pone.0070201