Search for compounds with antiviral activity among synthetic (-)-cytisine derivatives

Search for compounds with antiviral activity among synthetic (-)-cytisine derivatives

The antiviral activity of several amides and thio- and carboxamides of (-)-cytisine in addition to bromination and nitration products of its 2-pyridone core was studied. Compounds with a selectivity index close to 10 were found.

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Veröffentlicht in:Chemistry of natural compounds 2013, Vol.48 (6), p.1042-1046
Hauptverfasser: Tsypysheva, I. P., Koval’skaya, A. V., Lobov, A. N., Zarubaev, V. V., Karpinskaya, L. A., Petrenko, I. A., Nikolaeva, E. A., Shtro, A. A., Yunusov, M. S.
Format: Artikel
Sprache:eng
Schlagworte:
Antiviral agents
Medicine
Nitration
Organic Chemistry
Pharmacy
Plant Sciences
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Beschreibung
Zusammenfassung:The antiviral activity of several amides and thio- and carboxamides of (-)-cytisine in addition to bromination and nitration products of its 2-pyridone core was studied. Compounds with a selectivity index close to 10 were found.
ISSN:0009-3130
1573-8388
DOI:10.1007/s10600-013-0460-0