Fibroblast growth factor receptor 1 gene amplification in pancreatic ductal adenocarcinoma

Aims Pancreatic ductal adenocarcinomas (PDACs) are chemoresistant, resulting in extremely poor survival of patients; therefore, novel molecular targets, even in small subsets of genetically characterized tumours, are urgently needed. Tyrosine kinase receptor inhibitors (TKIs) are already in clinical...

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Veröffentlicht in:	Histopathology 2013-08, Vol.63 (2), p.157-166
Hauptverfasser:	Lehnen, Nils C, von Mässenhausen, Anne, Kalthoff, Holger, Zhou, Hui, Glowka, Tim, Schütte, Ute, Höller, Tobias, Riesner, Katarina, Boehm, Diana, Merkelbach-Bruse, Sabine, Kirfel, Jutta, Perner, Sven, Gütgemann, Ines
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Adult Aged Aged, 80 and over amplification Carcinoma, Pancreatic Ductal - genetics Carcinoma, Pancreatic Ductal - metabolism Carcinoma, Pancreatic Ductal - pathology Cell Line, Tumor Cells DNA, Neoplasm - genetics Female fibroblast growth factor receptor 1 fluorescence in-situ hybridization Gene Amplification Humans Immunohistochemistry In Situ Hybridization, Fluorescence Male Middle Aged Mutation Pancreas pancreatic ductal adenocarcinoma Pancreatic Neoplasms - genetics Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Prognosis Proteins Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins p21(ras) ras Proteins - genetics Receptor, Fibroblast Growth Factor, Type 1 - antagonists & inhibitors Receptor, Fibroblast Growth Factor, Type 1 - genetics Receptor, Fibroblast Growth Factor, Type 1 - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Neoplasm - genetics RNA, Neoplasm - metabolism Tissue Array Analysis
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