The calcium sensing receptor modulates fluid reabsorption and acid secretion in the proximal tubule

The proximal tubule uses a complex process of apical acid secretion and basolateral bicarbonate absorption to regulate both luminal acidification and fluid absorption. One of the primary regulators of apical acid secretion is the luminal sodium–hydrogen exchanger expressed along the apical membrane...

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Veröffentlicht in:	Kidney international 2013-08, Vol.84 (2), p.277-284
Hauptverfasser:	Capasso, Giovambattista, Geibel, Peter J., Damiano, Sara, Jaeger, Philippe, Richards, William G., Geibel, John P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid-Base Equilibrium - drug effects Animals Calcimimetic Agents - pharmacology Calcium - metabolism calcium-sensing receptor Hydrogen-Ion Concentration In Vitro Techniques intracellular pH ion transport kidney stones kidney tubule Kidney Tubules, Proximal - drug effects Kidney Tubules, Proximal - metabolism Male Mice Mice, Knockout Nuclear Proteins - genetics Nuclear Proteins - metabolism Perfusion Punctures Rats Rats, Sprague-Dawley Receptors, Calcium-Sensing - agonists Receptors, Calcium-Sensing - metabolism Receptors, G-Protein-Coupled - agonists Receptors, G-Protein-Coupled - deficiency Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Sodium-Hydrogen Exchangers - metabolism Transcription Factors - genetics Transcription Factors - metabolism
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