SAHA Treatment Reveals the Link between Histone Lysine Acetylation and Proteome in Nonsmall Cell Lung Cancer A549 Cells

Suberoylanilide hydroxamic acid (SAHA) is a well-known pan HDAC inhibitor, and its clinical application (Vorinostat) has been demonstrated to treat nonsmall cell lung cancer (NSCLS). Nevertheless, the impact of SAHA treatment on histone lysine acetylation and proteome in NSCLS cells still need furth...

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Veröffentlicht in:	Journal of proteome research 2013-09, Vol.12 (9), p.4064-4073
Hauptverfasser:	Wu, Quan, Xu, Weiqing, Cao, Lejie, Li, Xin, He, Tieming, Wu, Zhiwei, Li, Wenting
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Amino Acid Sequence Carcinoma, Non-Small-Cell Lung Cell Line, Tumor Cell Survival - drug effects Epigenesis, Genetic - drug effects Gene Ontology Histone Deacetylase Inhibitors - pharmacology Histones - chemistry Histones - metabolism Humans Hydroxamic Acids - pharmacology Lysine - metabolism Molecular Sequence Annotation Molecular Sequence Data Protein Processing, Post-Translational - drug effects Proteome - chemistry Proteome - metabolism
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