Inhaled alpha 1-Antitrypsin Administered to Treat Pneumatocele in Autosomal Dominant Hyperimmunoglobulin E Syndrome

Members of the serine protease, matrix metalloproteinase, and cysteinyl protease families have been found to be associated with lung inflammation and airway extracellular matrix [1]. The serine protease neutrophil elastase induces protease and tissue destruction in the lung [1]. Protease-antiproteas...

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Veröffentlicht in:Journal of investigational allergology & clinical immunology 2013-01, Vol.23 (5), p.359-361
Hauptverfasser: Karakoc-Aydiner, E, Baris, S, Keles, S, Ozdemir, C, Chatila, T, Barlan, I
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container_issue 5
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container_title Journal of investigational allergology & clinical immunology
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creator Karakoc-Aydiner, E
Baris, S
Keles, S
Ozdemir, C
Chatila, T
Barlan, I
description Members of the serine protease, matrix metalloproteinase, and cysteinyl protease families have been found to be associated with lung inflammation and airway extracellular matrix [1]. The serine protease neutrophil elastase induces protease and tissue destruction in the lung [1]. Protease-antiprotease imbalance in humans has been described in chronic destructive lung diseases such as cystic fibrosis and alpha -1 antitrypsin deficiency [2,3]. Aerosolized alpha -1 antitrypsin therapy has been administered to restore the protease-antiprotease imbalance and inhibit destructive lung inflammation [4,5].
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title Inhaled alpha 1-Antitrypsin Administered to Treat Pneumatocele in Autosomal Dominant Hyperimmunoglobulin E Syndrome
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