Bioreduction of Aryl Azides during Mutasynthesis of New Ansamitocins

Supplementing a culture of a mutant strain of Actinosynnema pretiosum that is unable to biosynthesize aminohydroxy benzoic acid (AHBA), with 3-azido-5-hydroxy-benzoic acid and 3-azido-5-amino-benzoic acid, unexpectedly yielded anilino ansamitocins instead of the expected azido derivatives. This is t...

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Veröffentlicht in:	Organic letters 2013-09, Vol.15 (17), p.4442-4445
Hauptverfasser:	Mancuso, Lena, Jürjens, Gerrit, Hermane, Jekaterina, Harmrolfs, Kirsten, Eichner, Simone, Fohrer, Jörg, Collisi, Wera, Sasse, Florenz, Kirschning, Andreas
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminobenzoates - chemistry Aminobenzoates - pharmacology Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Azides - chemistry Azides - pharmacology Benzoquinones - chemical synthesis Benzoquinones - chemistry Benzoquinones - pharmacology Drug Screening Assays, Antitumor Hydroxybenzoates - chemistry Hydroxybenzoates - pharmacology Lactams, Macrocyclic - chemical synthesis Lactams, Macrocyclic - chemistry Lactams, Macrocyclic - pharmacology Maytansine - analogs & derivatives Maytansine - chemical synthesis Maytansine - chemistry Maytansine - pharmacology Molecular Structure Streptomyces - chemistry Streptomyces - genetics Streptomyces - metabolism
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