Zinc‐induced modulation of SRSF6 activity alters Bim splicing to promote generation of the most potent apoptotic isoform BimS

Bim is a member of the pro‐apoptotic BH3‐only Bcl‐2 family of proteins. Bim gene undergoes alternative splicing to produce three predominant splicing variants (BimEL, BimL and BimS). The smallest variant BimS is the most potent inducer of apoptosis. Zinc (Zn²⁺) has been reported to stimulate apoptos...

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Veröffentlicht in:	The FEBS journal 2013-07, Vol.280 (14), p.3313-3327
Hauptverfasser:	Hara, Hirokazu, Takeda, Tatsuya, Yamamoto, Nozomi, Furuya, Keisuke, Hirose, Kazuya, Kamiya, Tetsuro, Adachi, Tetsuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative Splicing Apoptosis Apoptosis Regulatory Proteins - genetics Apoptosis Regulatory Proteins - metabolism Base Sequence Bcl-2-Like Protein 11 Bim Binding Sites Bioassays cadmium Cell Line, Tumor cobalt copper crosslinking endoplasmic reticulum exons genes genotoxicity HEK293 Cells Humans introns Membrane Proteins - genetics Membrane Proteins - metabolism messenger RNA Molecular Sequence Data Mutation Nuclear Proteins - metabolism Phosphoproteins - metabolism Phosphorylation Protein Binding Protein Isoforms - genetics Protein Isoforms - metabolism Protein Processing, Post-Translational proteins Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism RNA Precursors - genetics RNA Precursors - metabolism RNA-Binding Proteins - metabolism Serine-Arginine Splicing Factors splicing SRSF6 Transcription, Genetic Western blotting Zinc Zinc - physiology
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