Coarctation of the Aorta: Lifelong Surveillance Is Mandatory Following Surgical Repair
The objective of our study was to review the long-term outcomes of patients undergoing surgical repair of aortic coarctation. Surgical repair of aortic coarctation has been performed at the Mayo Clinic, Rochester, Minnesota, for over 60 years. Between 1946 and 2005, 819 patients with isolated coarct...
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| Veröffentlicht in: | Journal of the American College of Cardiology 2013-09, Vol.62 (11), p.1020-1025 |
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| container_title | Journal of the American College of Cardiology |
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| creator | BROWN, Morgan L BURKHART, Harold M CONNOLLY, Heidi M DEARANI, Joseph A CETTA, Frank ZHUO LI OLIVER, William C WARNES, Carole A SCHAFF, Hartzell V |
| description | The objective of our study was to review the long-term outcomes of patients undergoing surgical repair of aortic coarctation.
Surgical repair of aortic coarctation has been performed at the Mayo Clinic, Rochester, Minnesota, for over 60 years.
Between 1946 and 2005, 819 patients with isolated coarctation of the aorta underwent primary operative repair. Medical records were reviewed and questionnaires mailed to the patients.
Mean age at repair was 17.2 ± 13.6 years. The majority (83%) had pre-operative hypertension. Operations included simple and extended end-to-end anastomosis (n = 632), patch angioplasty (n = 72), interposition grafting (n = 49), bypass grafting (n = 30), and subclavian flap or "other" (n = 35). Overall early mortality (20 yrs) and pre-operative hypertension were associated with decreased survival (p < 0.001). Patients age |
| doi_str_mv | 10.1016/j.jacc.2013.06.016 |
| format | Article |
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Surgical repair of aortic coarctation has been performed at the Mayo Clinic, Rochester, Minnesota, for over 60 years.
Between 1946 and 2005, 819 patients with isolated coarctation of the aorta underwent primary operative repair. Medical records were reviewed and questionnaires mailed to the patients.
Mean age at repair was 17.2 ± 13.6 years. The majority (83%) had pre-operative hypertension. Operations included simple and extended end-to-end anastomosis (n = 632), patch angioplasty (n = 72), interposition grafting (n = 49), bypass grafting (n = 30), and subclavian flap or "other" (n = 35). Overall early mortality (<30 days) was 2.4%. In the previous 30 years (n = 225), there were no operative deaths. Mean follow-up was 17.4 ± 13.9 years, with a maximum of 59.3 years. Actuarial survival rates were 93.3%, 86.4%, and 73.5% at 10, 20, and 30 years, respectively. When compared to an age- and sex-matched population, long-term survival was decreased (p < 0.001). Older age at repair (>20 yrs) and pre-operative hypertension were associated with decreased survival (p < 0.001). Patients age <9 years age at repair had significantly less hypertension at 5 to 15 years of follow-up (p < 0.001). Rates of freedom from re-intervention on the descending aorta were 96.7%, 92.2%, and 89.4% at 10, 20, and 30 years, respectively. Younger age at time of repair (p < 0.001) and an end-to-end anastomosis technique (p < 0.001) were independently associated with lower rates of re-intervention on the descending aorta.
Primary repair of isolated coarctation of the aorta was performed with a low rate of mortality. However, long-term survival was reduced compared with that in an age- and sex-matched population, and many patients required further reoperation. These findings emphasize that patients with aortic coarctation need early recognition and intervention, as well as lifelong informed follow-up.]]></description><identifier>ISSN: 0735-1097</identifier><identifier>EISSN: 1558-3597</identifier><identifier>DOI: 10.1016/j.jacc.2013.06.016</identifier><identifier>PMID: 23850909</identifier><identifier>CODEN: JACCDI</identifier><language>eng</language><publisher>New York, NY: Elsevier</publisher><subject>Adolescent ; Adult ; Aorta - surgery ; Aortic Coarctation - complications ; Aortic Coarctation - mortality ; Aortic Coarctation - surgery ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Child ; Child, Preschool ; Cohort Studies ; Diseases of the aorta ; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous ; Follow-Up Studies ; Heart ; Humans ; Hypertension - epidemiology ; Hypertension - etiology ; Infant ; Medical Records ; Medical sciences ; Reoperation - statistics & numerical data ; Surveys and Questionnaires ; Survival Rate ; Treatment Outcome ; Young Adult</subject><ispartof>Journal of the American College of Cardiology, 2013-09, Vol.62 (11), p.1020-1025</ispartof><rights>2014 INIST-CNRS</rights><rights>Copyright © 2013 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27720553$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23850909$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BROWN, Morgan L</creatorcontrib><creatorcontrib>BURKHART, Harold M</creatorcontrib><creatorcontrib>CONNOLLY, Heidi M</creatorcontrib><creatorcontrib>DEARANI, Joseph A</creatorcontrib><creatorcontrib>CETTA, Frank</creatorcontrib><creatorcontrib>ZHUO LI</creatorcontrib><creatorcontrib>OLIVER, William C</creatorcontrib><creatorcontrib>WARNES, Carole A</creatorcontrib><creatorcontrib>SCHAFF, Hartzell V</creatorcontrib><title>Coarctation of the Aorta: Lifelong Surveillance Is Mandatory Following Surgical Repair</title><title>Journal of the American College of Cardiology</title><addtitle>J Am Coll Cardiol</addtitle><description><![CDATA[The objective of our study was to review the long-term outcomes of patients undergoing surgical repair of aortic coarctation.
Surgical repair of aortic coarctation has been performed at the Mayo Clinic, Rochester, Minnesota, for over 60 years.
Between 1946 and 2005, 819 patients with isolated coarctation of the aorta underwent primary operative repair. Medical records were reviewed and questionnaires mailed to the patients.
Mean age at repair was 17.2 ± 13.6 years. The majority (83%) had pre-operative hypertension. Operations included simple and extended end-to-end anastomosis (n = 632), patch angioplasty (n = 72), interposition grafting (n = 49), bypass grafting (n = 30), and subclavian flap or "other" (n = 35). Overall early mortality (<30 days) was 2.4%. In the previous 30 years (n = 225), there were no operative deaths. Mean follow-up was 17.4 ± 13.9 years, with a maximum of 59.3 years. Actuarial survival rates were 93.3%, 86.4%, and 73.5% at 10, 20, and 30 years, respectively. When compared to an age- and sex-matched population, long-term survival was decreased (p < 0.001). Older age at repair (>20 yrs) and pre-operative hypertension were associated with decreased survival (p < 0.001). Patients age <9 years age at repair had significantly less hypertension at 5 to 15 years of follow-up (p < 0.001). Rates of freedom from re-intervention on the descending aorta were 96.7%, 92.2%, and 89.4% at 10, 20, and 30 years, respectively. Younger age at time of repair (p < 0.001) and an end-to-end anastomosis technique (p < 0.001) were independently associated with lower rates of re-intervention on the descending aorta.
Primary repair of isolated coarctation of the aorta was performed with a low rate of mortality. However, long-term survival was reduced compared with that in an age- and sex-matched population, and many patients required further reoperation. These findings emphasize that patients with aortic coarctation need early recognition and intervention, as well as lifelong informed follow-up.]]></description><subject>Adolescent</subject><subject>Adult</subject><subject>Aorta - surgery</subject><subject>Aortic Coarctation - complications</subject><subject>Aortic Coarctation - mortality</subject><subject>Aortic Coarctation - surgery</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cohort Studies</subject><subject>Diseases of the aorta</subject><subject>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</subject><subject>Follow-Up Studies</subject><subject>Heart</subject><subject>Humans</subject><subject>Hypertension - epidemiology</subject><subject>Hypertension - etiology</subject><subject>Infant</subject><subject>Medical Records</subject><subject>Medical sciences</subject><subject>Reoperation - statistics & numerical data</subject><subject>Surveys and Questionnaires</subject><subject>Survival Rate</subject><subject>Treatment Outcome</subject><subject>Young Adult</subject><issn>0735-1097</issn><issn>1558-3597</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0N9LwzAQB_AgipvTf8AHyYvgS-ulaZrGNxlOBxPBX6_llqYzo2tq0ir7761s4tNxx4fjvkfIOYOYAcuu1_EatY4TYDyGLB5GB2TMhMgjLpQ8JGOQXEQMlByRkxDWAJDlTB2TUcJzAQrUmLxPHXrdYWddQ11Fuw9Db53v8IYubGVq16zoS--_jK1rbLSh80AfsSmxc35LZ66u3bfdmZXVWNNn06L1p-SowjqYs32dkLfZ3ev0IVo83c-nt4uoTVLWRYqDTlWSQImpKHNgzHDOKoFlxbVUidAMM5Zn5dBoWKYgM6EQVYYJ5xnkfEKudntb7z57E7piY4M2v7ca14eCpRzyVAKogV7sab_cmLJovd2g3xZ_vxjA5R5gGJJUfshrw7-TMgEhOP8BiettgA</recordid><startdate>20130910</startdate><enddate>20130910</enddate><creator>BROWN, Morgan L</creator><creator>BURKHART, Harold M</creator><creator>CONNOLLY, Heidi M</creator><creator>DEARANI, Joseph A</creator><creator>CETTA, Frank</creator><creator>ZHUO LI</creator><creator>OLIVER, William C</creator><creator>WARNES, Carole A</creator><creator>SCHAFF, Hartzell V</creator><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20130910</creationdate><title>Coarctation of the Aorta: Lifelong Surveillance Is Mandatory Following Surgical Repair</title><author>BROWN, Morgan L ; BURKHART, Harold M ; CONNOLLY, Heidi M ; DEARANI, Joseph A ; CETTA, Frank ; ZHUO LI ; OLIVER, William C ; WARNES, Carole A ; SCHAFF, Hartzell V</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p241t-930c49220da45d8011e331f5adf3c7925c1a6186dc79c0b407659aa96a2336083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aorta - surgery</topic><topic>Aortic Coarctation - complications</topic><topic>Aortic Coarctation - mortality</topic><topic>Aortic Coarctation - surgery</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiology. Vascular system</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cohort Studies</topic><topic>Diseases of the aorta</topic><topic>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</topic><topic>Follow-Up Studies</topic><topic>Heart</topic><topic>Humans</topic><topic>Hypertension - epidemiology</topic><topic>Hypertension - etiology</topic><topic>Infant</topic><topic>Medical Records</topic><topic>Medical sciences</topic><topic>Reoperation - statistics & numerical data</topic><topic>Surveys and Questionnaires</topic><topic>Survival Rate</topic><topic>Treatment Outcome</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BROWN, Morgan L</creatorcontrib><creatorcontrib>BURKHART, Harold M</creatorcontrib><creatorcontrib>CONNOLLY, Heidi M</creatorcontrib><creatorcontrib>DEARANI, Joseph A</creatorcontrib><creatorcontrib>CETTA, Frank</creatorcontrib><creatorcontrib>ZHUO LI</creatorcontrib><creatorcontrib>OLIVER, William C</creatorcontrib><creatorcontrib>WARNES, Carole A</creatorcontrib><creatorcontrib>SCHAFF, Hartzell V</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American College of Cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BROWN, Morgan L</au><au>BURKHART, Harold M</au><au>CONNOLLY, Heidi M</au><au>DEARANI, Joseph A</au><au>CETTA, Frank</au><au>ZHUO LI</au><au>OLIVER, William C</au><au>WARNES, Carole A</au><au>SCHAFF, Hartzell V</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Coarctation of the Aorta: Lifelong Surveillance Is Mandatory Following Surgical Repair</atitle><jtitle>Journal of the American College of Cardiology</jtitle><addtitle>J Am Coll Cardiol</addtitle><date>2013-09-10</date><risdate>2013</risdate><volume>62</volume><issue>11</issue><spage>1020</spage><epage>1025</epage><pages>1020-1025</pages><issn>0735-1097</issn><eissn>1558-3597</eissn><coden>JACCDI</coden><abstract><![CDATA[The objective of our study was to review the long-term outcomes of patients undergoing surgical repair of aortic coarctation.
Surgical repair of aortic coarctation has been performed at the Mayo Clinic, Rochester, Minnesota, for over 60 years.
Between 1946 and 2005, 819 patients with isolated coarctation of the aorta underwent primary operative repair. Medical records were reviewed and questionnaires mailed to the patients.
Mean age at repair was 17.2 ± 13.6 years. The majority (83%) had pre-operative hypertension. Operations included simple and extended end-to-end anastomosis (n = 632), patch angioplasty (n = 72), interposition grafting (n = 49), bypass grafting (n = 30), and subclavian flap or "other" (n = 35). Overall early mortality (<30 days) was 2.4%. In the previous 30 years (n = 225), there were no operative deaths. Mean follow-up was 17.4 ± 13.9 years, with a maximum of 59.3 years. Actuarial survival rates were 93.3%, 86.4%, and 73.5% at 10, 20, and 30 years, respectively. When compared to an age- and sex-matched population, long-term survival was decreased (p < 0.001). Older age at repair (>20 yrs) and pre-operative hypertension were associated with decreased survival (p < 0.001). Patients age <9 years age at repair had significantly less hypertension at 5 to 15 years of follow-up (p < 0.001). Rates of freedom from re-intervention on the descending aorta were 96.7%, 92.2%, and 89.4% at 10, 20, and 30 years, respectively. Younger age at time of repair (p < 0.001) and an end-to-end anastomosis technique (p < 0.001) were independently associated with lower rates of re-intervention on the descending aorta.
Primary repair of isolated coarctation of the aorta was performed with a low rate of mortality. However, long-term survival was reduced compared with that in an age- and sex-matched population, and many patients required further reoperation. These findings emphasize that patients with aortic coarctation need early recognition and intervention, as well as lifelong informed follow-up.]]></abstract><cop>New York, NY</cop><pub>Elsevier</pub><pmid>23850909</pmid><doi>10.1016/j.jacc.2013.06.016</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present); Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adolescent Adult Aorta - surgery Aortic Coarctation - complications Aortic Coarctation - mortality Aortic Coarctation - surgery Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Child Child, Preschool Cohort Studies Diseases of the aorta Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Follow-Up Studies Heart Humans Hypertension - epidemiology Hypertension - etiology Infant Medical Records Medical sciences Reoperation - statistics & numerical data Surveys and Questionnaires Survival Rate Treatment Outcome Young Adult |
| title | Coarctation of the Aorta: Lifelong Surveillance Is Mandatory Following Surgical Repair |
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