The relationship between the optical density of cataract and its influence on retinal nerve fibre layer thickness measured with spectral domain optical coherence tomography
. Purpose: The purpose of this study was to model the influence of cataract on Spectral Domain Optical Coherence Tomography (SDOCT) image quality and Retinal Nerve Fibre Layer (RNFL) thickness measurements. Methods: SDOCT images, made with two different devices (3DOCT‐1000, Topcon and Cirrus HD‐OC...
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| Veröffentlicht in: | Acta ophthalmologica (Oxford, England) England), 2013-08, Vol.91 (5), p.418-424 |
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| creator | Kok, Pauline H. B. van den Berg, Thomas J. T. P. van Dijk, Hille W. Stehouwer, Marilette van der Meulen, Ivanka J. E. Mourits, Maarten P. Verbraak, Frank D. |
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Purpose: The purpose of this study was to model the influence of cataract on Spectral Domain Optical Coherence Tomography (SDOCT) image quality and Retinal Nerve Fibre Layer (RNFL) thickness measurements.
Methods: SDOCT images, made with two different devices (3DOCT‐1000, Topcon and Cirrus HD‐OCT), before and after cataract surgery were compared and judged against measurements from normal subjects using artificial filters simulating the effects of cataract. Optical density of the images was calculated based on a mathematical model described previously.
Results: In total, forty‐eight eyes were included for pre‐ and postoperative cataract extraction measurements. OCT image quality significantly (p |
| doi_str_mv | 10.1111/j.1755-3768.2012.02514.x |
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Purpose: The purpose of this study was to model the influence of cataract on Spectral Domain Optical Coherence Tomography (SDOCT) image quality and Retinal Nerve Fibre Layer (RNFL) thickness measurements.
Methods: SDOCT images, made with two different devices (3DOCT‐1000, Topcon and Cirrus HD‐OCT), before and after cataract surgery were compared and judged against measurements from normal subjects using artificial filters simulating the effects of cataract. Optical density of the images was calculated based on a mathematical model described previously.
Results: In total, forty‐eight eyes were included for pre‐ and postoperative cataract extraction measurements. OCT image quality significantly (p < 0.001) improved postoperative and postoperative RNFL thickness was significantly (p < 0.001) thicker in both groups of patients. The measurements using artificial filters showed a rather precise linear relation between change in filter induced optical density and change in RNFL thickness (R = 0.941, p < 0.001 for 3DOCT‐1000 and R = 0.785, p < 0.001 for Cirrus HD‐OCT). For the patient groups, the relation was less marked, 3DOCT‐1000 Rs = 0.697, p < 0.03 and Cirrus HD‐OCT Rs = 0.444, p < 0.03. The predictive potential based on the found linear relationship between OCT‐effective optical density of cataract and the cataract‐induced underestimation was however limited, and mean difference ± SD between predicted and measured RNFL thickness were 1.68 ± 7.55 (3DOCT‐1000) and 3.71 ± 2.97 (Cirrus HD‐OCT) micron.
Conclusions: A linear relationship exists between OCT‐effective optical density of cataract and underestimation of RNFL thickness measured with OCT. This finding holds promise to correct for cataract‐induced changes in RNFL measurements, but will differ for each type of OCT device.]]></description><identifier>ISSN: 1755-375X</identifier><identifier>EISSN: 1755-3768</identifier><identifier>DOI: 10.1111/j.1755-3768.2012.02514.x</identifier><identifier>PMID: 23106951</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Aged ; Algorithms ; cataract ; Cataract - pathology ; Cataract Extraction ; Female ; Humans ; image quality ; Lens, Crystalline ; Male ; Nerve Fibers - pathology ; Ophthalmology ; optical coherence tomography ; Postoperative Period ; Preoperative Period ; Retinal Ganglion Cells - pathology ; retinal nerve fibre layer ; Tomography, Optical Coherence - methods</subject><ispartof>Acta ophthalmologica (Oxford, England), 2013-08, Vol.91 (5), p.418-424</ispartof><rights>2012 The Authors. Acta Ophthalmologica © 2012 Acta Ophthalmologica Scandinavica Foundation</rights><rights>2012 The Authors. Acta Ophthalmologica © 2012 Acta Ophthalmologica Scandinavica Foundation.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4634-b3ce6df8b95ae331721f991820d23fc7b4219f3bc91636bf0e304d40c3b15c113</citedby><cites>FETCH-LOGICAL-c4634-b3ce6df8b95ae331721f991820d23fc7b4219f3bc91636bf0e304d40c3b15c113</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1755-3768.2012.02514.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1755-3768.2012.02514.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23106951$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kok, Pauline H. B.</creatorcontrib><creatorcontrib>van den Berg, Thomas J. T. P.</creatorcontrib><creatorcontrib>van Dijk, Hille W.</creatorcontrib><creatorcontrib>Stehouwer, Marilette</creatorcontrib><creatorcontrib>van der Meulen, Ivanka J. E.</creatorcontrib><creatorcontrib>Mourits, Maarten P.</creatorcontrib><creatorcontrib>Verbraak, Frank D.</creatorcontrib><title>The relationship between the optical density of cataract and its influence on retinal nerve fibre layer thickness measured with spectral domain optical coherence tomography</title><title>Acta ophthalmologica (Oxford, England)</title><addtitle>Acta Ophthalmol</addtitle><description><![CDATA[.
Purpose: The purpose of this study was to model the influence of cataract on Spectral Domain Optical Coherence Tomography (SDOCT) image quality and Retinal Nerve Fibre Layer (RNFL) thickness measurements.
Methods: SDOCT images, made with two different devices (3DOCT‐1000, Topcon and Cirrus HD‐OCT), before and after cataract surgery were compared and judged against measurements from normal subjects using artificial filters simulating the effects of cataract. Optical density of the images was calculated based on a mathematical model described previously.
Results: In total, forty‐eight eyes were included for pre‐ and postoperative cataract extraction measurements. OCT image quality significantly (p < 0.001) improved postoperative and postoperative RNFL thickness was significantly (p < 0.001) thicker in both groups of patients. The measurements using artificial filters showed a rather precise linear relation between change in filter induced optical density and change in RNFL thickness (R = 0.941, p < 0.001 for 3DOCT‐1000 and R = 0.785, p < 0.001 for Cirrus HD‐OCT). For the patient groups, the relation was less marked, 3DOCT‐1000 Rs = 0.697, p < 0.03 and Cirrus HD‐OCT Rs = 0.444, p < 0.03. The predictive potential based on the found linear relationship between OCT‐effective optical density of cataract and the cataract‐induced underestimation was however limited, and mean difference ± SD between predicted and measured RNFL thickness were 1.68 ± 7.55 (3DOCT‐1000) and 3.71 ± 2.97 (Cirrus HD‐OCT) micron.
Conclusions: A linear relationship exists between OCT‐effective optical density of cataract and underestimation of RNFL thickness measured with OCT. This finding holds promise to correct for cataract‐induced changes in RNFL measurements, but will differ for each type of OCT device.]]></description><subject>Aged</subject><subject>Algorithms</subject><subject>cataract</subject><subject>Cataract - pathology</subject><subject>Cataract Extraction</subject><subject>Female</subject><subject>Humans</subject><subject>image quality</subject><subject>Lens, Crystalline</subject><subject>Male</subject><subject>Nerve Fibers - pathology</subject><subject>Ophthalmology</subject><subject>optical coherence tomography</subject><subject>Postoperative Period</subject><subject>Preoperative Period</subject><subject>Retinal Ganglion Cells - pathology</subject><subject>retinal nerve fibre layer</subject><subject>Tomography, Optical Coherence - methods</subject><issn>1755-375X</issn><issn>1755-3768</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc9u1DAQhyMEoqXwCsgSFy4b7Nhx4gOHquKfVKkHisTNcpwx8ZLYwXbY5p14SJxu2QMX8MUjzTe_keYrCkRwSfJ7sy9JU9c72vC2rDCpSlzVhJV3j4rzU-Pxqa6_nhXPYtxjzAnn7GlxVlGCuajJefHrdgAUYFTJehcHO6MO0gHAoZQbfk5WqxH14KJNK_IGaZVUUDoh5XpkU0TWmXEBpzPtclKyLg84CD8BGdsFQKNaIeQ4q787iBFNoOISoEcHmwYUZ9ApbDv8pKw7rdR-gHAfm_zkvwU1D-vz4olRY4QXD_9F8eX9u9urj7vrmw-fri6vd5pxynYd1cB703aiVkApaSpihCBthfuKGt10rCLC0E4LwinvDAaKWc-wph2pNSH0onh9zJ2D_7FATHKyUcM4Kgd-iZIwilvGedP8G6VCCFpVHGf01V_o3i8hX2sLzGqEYKzOVHukdPAxBjByDnZSYZUEy02-3MvNq9wcy02-vJcv7_Loy4cFSzdBfxr8YzsDb4_AwY6w_newvLz5vFX0N7MqwIg</recordid><startdate>201308</startdate><enddate>201308</enddate><creator>Kok, Pauline H. B.</creator><creator>van den Berg, Thomas J. T. P.</creator><creator>van Dijk, Hille W.</creator><creator>Stehouwer, Marilette</creator><creator>van der Meulen, Ivanka J. E.</creator><creator>Mourits, Maarten P.</creator><creator>Verbraak, Frank D.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>201308</creationdate><title>The relationship between the optical density of cataract and its influence on retinal nerve fibre layer thickness measured with spectral domain optical coherence tomography</title><author>Kok, Pauline H. B. ; van den Berg, Thomas J. T. P. ; van Dijk, Hille W. ; Stehouwer, Marilette ; van der Meulen, Ivanka J. E. ; Mourits, Maarten P. ; Verbraak, Frank D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4634-b3ce6df8b95ae331721f991820d23fc7b4219f3bc91636bf0e304d40c3b15c113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Aged</topic><topic>Algorithms</topic><topic>cataract</topic><topic>Cataract - pathology</topic><topic>Cataract Extraction</topic><topic>Female</topic><topic>Humans</topic><topic>image quality</topic><topic>Lens, Crystalline</topic><topic>Male</topic><topic>Nerve Fibers - pathology</topic><topic>Ophthalmology</topic><topic>optical coherence tomography</topic><topic>Postoperative Period</topic><topic>Preoperative Period</topic><topic>Retinal Ganglion Cells - pathology</topic><topic>retinal nerve fibre layer</topic><topic>Tomography, Optical Coherence - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kok, Pauline H. B.</creatorcontrib><creatorcontrib>van den Berg, Thomas J. T. P.</creatorcontrib><creatorcontrib>van Dijk, Hille W.</creatorcontrib><creatorcontrib>Stehouwer, Marilette</creatorcontrib><creatorcontrib>van der Meulen, Ivanka J. E.</creatorcontrib><creatorcontrib>Mourits, Maarten P.</creatorcontrib><creatorcontrib>Verbraak, Frank D.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Acta ophthalmologica (Oxford, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kok, Pauline H. B.</au><au>van den Berg, Thomas J. T. P.</au><au>van Dijk, Hille W.</au><au>Stehouwer, Marilette</au><au>van der Meulen, Ivanka J. E.</au><au>Mourits, Maarten P.</au><au>Verbraak, Frank D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The relationship between the optical density of cataract and its influence on retinal nerve fibre layer thickness measured with spectral domain optical coherence tomography</atitle><jtitle>Acta ophthalmologica (Oxford, England)</jtitle><addtitle>Acta Ophthalmol</addtitle><date>2013-08</date><risdate>2013</risdate><volume>91</volume><issue>5</issue><spage>418</spage><epage>424</epage><pages>418-424</pages><issn>1755-375X</issn><eissn>1755-3768</eissn><abstract><![CDATA[.
Purpose: The purpose of this study was to model the influence of cataract on Spectral Domain Optical Coherence Tomography (SDOCT) image quality and Retinal Nerve Fibre Layer (RNFL) thickness measurements.
Methods: SDOCT images, made with two different devices (3DOCT‐1000, Topcon and Cirrus HD‐OCT), before and after cataract surgery were compared and judged against measurements from normal subjects using artificial filters simulating the effects of cataract. Optical density of the images was calculated based on a mathematical model described previously.
Results: In total, forty‐eight eyes were included for pre‐ and postoperative cataract extraction measurements. OCT image quality significantly (p < 0.001) improved postoperative and postoperative RNFL thickness was significantly (p < 0.001) thicker in both groups of patients. The measurements using artificial filters showed a rather precise linear relation between change in filter induced optical density and change in RNFL thickness (R = 0.941, p < 0.001 for 3DOCT‐1000 and R = 0.785, p < 0.001 for Cirrus HD‐OCT). For the patient groups, the relation was less marked, 3DOCT‐1000 Rs = 0.697, p < 0.03 and Cirrus HD‐OCT Rs = 0.444, p < 0.03. The predictive potential based on the found linear relationship between OCT‐effective optical density of cataract and the cataract‐induced underestimation was however limited, and mean difference ± SD between predicted and measured RNFL thickness were 1.68 ± 7.55 (3DOCT‐1000) and 3.71 ± 2.97 (Cirrus HD‐OCT) micron.
Conclusions: A linear relationship exists between OCT‐effective optical density of cataract and underestimation of RNFL thickness measured with OCT. This finding holds promise to correct for cataract‐induced changes in RNFL measurements, but will differ for each type of OCT device.]]></abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>23106951</pmid><doi>10.1111/j.1755-3768.2012.02514.x</doi><tpages>7</tpages></addata></record> |
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| subjects | Aged Algorithms cataract Cataract - pathology Cataract Extraction Female Humans image quality Lens, Crystalline Male Nerve Fibers - pathology Ophthalmology optical coherence tomography Postoperative Period Preoperative Period Retinal Ganglion Cells - pathology retinal nerve fibre layer Tomography, Optical Coherence - methods |
| title | The relationship between the optical density of cataract and its influence on retinal nerve fibre layer thickness measured with spectral domain optical coherence tomography |
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