Proactive treatment of adult facial seborrhoeic dermatitis with 0.1% tacrolimus ointment: randomized, double-blind, vehicle-controlled, multi-centre trial
The effectiveness of intermittent topical tacrolimus to prevent relapse in patients with stabilized facial seborrhoeic dermatitis has not been evaluated. The aim of this study was to determine whether proactive use of 0.1% tacrolimus ointment can keep adult facial seborrhoeic dermatitis in remission...
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| Veröffentlicht in: | Acta dermato-venereologica 2013-01, Vol.93 (5), p.557-561 |
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| container_title | Acta dermato-venereologica |
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| creator | Kim, Tae-Wook Mun, Je-Ho Jwa, Seung-Wook Song, Margaret Kim, Hoon-Soo Ko, Hyun-Chang Kim, Moon-Bum Song, Ki-Hoon Lee, Sook-Kyung Seo, Jong-Keun Lee, Deborah Kim, Byung-Soo |
| description | The effectiveness of intermittent topical tacrolimus to prevent relapse in patients with stabilized facial seborrhoeic dermatitis has not been evaluated. The aim of this study was to determine whether proactive use of 0.1% tacrolimus ointment can keep adult facial seborrhoeic dermatitis in remission. A total of 75 patients who had stabilized facial seborrhoeic dermatitis after 2 weeks' (open-label induction) treatment with 0.1% tacrolimus were randomized in a double-blind fashion to treatment with 0.1% tacrolimus once a week, twice a week, or vehicle twice a week, for 10 weeks (maintenance). Significant improvement in erythema, scaling and pruritus compared with baseline was maintained during the maintenance phase in both tacrolimus groups, but not in the vehicle group. The mean recurrence rate according to global assessment was significantly higher in the tacrolimus once-weekly group than in the twice-weekly group. In conclusion, twice-weekly treatment with 0.1% tacrolimus ointment had superior effects in keeping facial seborrhoeic dermatitis in remission. |
| doi_str_mv | 10.2340/00015555-1532 |
| format | Article |
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The aim of this study was to determine whether proactive use of 0.1% tacrolimus ointment can keep adult facial seborrhoeic dermatitis in remission. A total of 75 patients who had stabilized facial seborrhoeic dermatitis after 2 weeks' (open-label induction) treatment with 0.1% tacrolimus were randomized in a double-blind fashion to treatment with 0.1% tacrolimus once a week, twice a week, or vehicle twice a week, for 10 weeks (maintenance). Significant improvement in erythema, scaling and pruritus compared with baseline was maintained during the maintenance phase in both tacrolimus groups, but not in the vehicle group. The mean recurrence rate according to global assessment was significantly higher in the tacrolimus once-weekly group than in the twice-weekly group. In conclusion, twice-weekly treatment with 0.1% tacrolimus ointment had superior effects in keeping facial seborrhoeic dermatitis in remission.</description><identifier>ISSN: 0001-5555</identifier><identifier>EISSN: 1651-2057</identifier><identifier>DOI: 10.2340/00015555-1532</identifier><identifier>PMID: 23388687</identifier><language>eng</language><publisher>Sweden</publisher><subject>Administration, Cutaneous ; Adult ; Aged ; Chi-Square Distribution ; Dermatitis, Seborrheic - diagnosis ; Dermatitis, Seborrheic - drug therapy ; Dermatologic Agents - administration & dosage ; Dermatologic Agents - adverse effects ; Double-Blind Method ; Drug Administration Schedule ; Facial Dermatoses - diagnosis ; Facial Dermatoses - drug therapy ; Female ; Humans ; Male ; Middle Aged ; Ointments ; Remission Induction ; Republic of Korea ; Secondary Prevention ; Tacrolimus - administration & dosage ; Tacrolimus - adverse effects ; Time Factors ; Treatment Outcome</subject><ispartof>Acta dermato-venereologica, 2013-01, Vol.93 (5), p.557-561</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c332t-55e8383b38cf7a75b9631e0ae1ea0a620aa89f26f635e28f61e2fa606406acd23</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23388687$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Tae-Wook</creatorcontrib><creatorcontrib>Mun, Je-Ho</creatorcontrib><creatorcontrib>Jwa, Seung-Wook</creatorcontrib><creatorcontrib>Song, Margaret</creatorcontrib><creatorcontrib>Kim, Hoon-Soo</creatorcontrib><creatorcontrib>Ko, Hyun-Chang</creatorcontrib><creatorcontrib>Kim, Moon-Bum</creatorcontrib><creatorcontrib>Song, Ki-Hoon</creatorcontrib><creatorcontrib>Lee, Sook-Kyung</creatorcontrib><creatorcontrib>Seo, Jong-Keun</creatorcontrib><creatorcontrib>Lee, Deborah</creatorcontrib><creatorcontrib>Kim, Byung-Soo</creatorcontrib><title>Proactive treatment of adult facial seborrhoeic dermatitis with 0.1% tacrolimus ointment: randomized, double-blind, vehicle-controlled, multi-centre trial</title><title>Acta dermato-venereologica</title><addtitle>Acta Derm Venereol</addtitle><description>The effectiveness of intermittent topical tacrolimus to prevent relapse in patients with stabilized facial seborrhoeic dermatitis has not been evaluated. The aim of this study was to determine whether proactive use of 0.1% tacrolimus ointment can keep adult facial seborrhoeic dermatitis in remission. A total of 75 patients who had stabilized facial seborrhoeic dermatitis after 2 weeks' (open-label induction) treatment with 0.1% tacrolimus were randomized in a double-blind fashion to treatment with 0.1% tacrolimus once a week, twice a week, or vehicle twice a week, for 10 weeks (maintenance). Significant improvement in erythema, scaling and pruritus compared with baseline was maintained during the maintenance phase in both tacrolimus groups, but not in the vehicle group. The mean recurrence rate according to global assessment was significantly higher in the tacrolimus once-weekly group than in the twice-weekly group. In conclusion, twice-weekly treatment with 0.1% tacrolimus ointment had superior effects in keeping facial seborrhoeic dermatitis in remission.</description><subject>Administration, Cutaneous</subject><subject>Adult</subject><subject>Aged</subject><subject>Chi-Square Distribution</subject><subject>Dermatitis, Seborrheic - diagnosis</subject><subject>Dermatitis, Seborrheic - drug therapy</subject><subject>Dermatologic Agents - administration & dosage</subject><subject>Dermatologic Agents - adverse effects</subject><subject>Double-Blind Method</subject><subject>Drug Administration Schedule</subject><subject>Facial Dermatoses - diagnosis</subject><subject>Facial Dermatoses - drug therapy</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Ointments</subject><subject>Remission Induction</subject><subject>Republic of Korea</subject><subject>Secondary Prevention</subject><subject>Tacrolimus - administration & dosage</subject><subject>Tacrolimus - adverse effects</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><issn>0001-5555</issn><issn>1651-2057</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kU9LJDEQxYMo6zh69Cq5CB5szZ_pTMabiO4KA3rYPTfV6QoTSXc0Sc-iH8VPa3rVzSU86levUnmEHHN2IeSCXTLGeF1OxWspdsiMq5pXgtXLXTKbatVU3CcHKT0VKWquf5B9IaXWSi9n5P0xBjDZbZHmiJB7HDINlkI3-kwtGAeeJmxDjJuAztAOYw_ZZZfoX5c3lF3wU5rBxOBdPyYa3PDP5IpGGLrQuzfszmkXxtZj1Xo3FLXFjTNFmjDk0ucnoi_zXGVKZ5yeUsYekj0LPuHR1z0nf-5uf9_8qtYPP-9vrteVkVLksh9qqWUrtbFLWNbtSkmODJAjMFCCAeiVFcoqWaPQVnEUFhRTC6bAdELOydmn73MMLyOm3PQuGfQeBgxjavhCMrnSSqiCVp9oWTeliLZ5jq6H-Npw1kxxNN9xNFMchT_5sh7bHrv_9Pf_yw8D1Idv</recordid><startdate>20130101</startdate><enddate>20130101</enddate><creator>Kim, Tae-Wook</creator><creator>Mun, Je-Ho</creator><creator>Jwa, Seung-Wook</creator><creator>Song, Margaret</creator><creator>Kim, Hoon-Soo</creator><creator>Ko, Hyun-Chang</creator><creator>Kim, Moon-Bum</creator><creator>Song, Ki-Hoon</creator><creator>Lee, Sook-Kyung</creator><creator>Seo, Jong-Keun</creator><creator>Lee, Deborah</creator><creator>Kim, Byung-Soo</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130101</creationdate><title>Proactive treatment of adult facial seborrhoeic dermatitis with 0.1% tacrolimus ointment: randomized, double-blind, vehicle-controlled, multi-centre trial</title><author>Kim, Tae-Wook ; Mun, Je-Ho ; Jwa, Seung-Wook ; Song, Margaret ; Kim, Hoon-Soo ; Ko, Hyun-Chang ; Kim, Moon-Bum ; Song, Ki-Hoon ; Lee, Sook-Kyung ; Seo, Jong-Keun ; Lee, Deborah ; Kim, Byung-Soo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c332t-55e8383b38cf7a75b9631e0ae1ea0a620aa89f26f635e28f61e2fa606406acd23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Administration, Cutaneous</topic><topic>Adult</topic><topic>Aged</topic><topic>Chi-Square Distribution</topic><topic>Dermatitis, Seborrheic - diagnosis</topic><topic>Dermatitis, Seborrheic - drug therapy</topic><topic>Dermatologic Agents - administration & dosage</topic><topic>Dermatologic Agents - adverse effects</topic><topic>Double-Blind Method</topic><topic>Drug Administration Schedule</topic><topic>Facial Dermatoses - diagnosis</topic><topic>Facial Dermatoses - drug therapy</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Ointments</topic><topic>Remission Induction</topic><topic>Republic of Korea</topic><topic>Secondary Prevention</topic><topic>Tacrolimus - administration & dosage</topic><topic>Tacrolimus - adverse effects</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Tae-Wook</creatorcontrib><creatorcontrib>Mun, Je-Ho</creatorcontrib><creatorcontrib>Jwa, Seung-Wook</creatorcontrib><creatorcontrib>Song, Margaret</creatorcontrib><creatorcontrib>Kim, Hoon-Soo</creatorcontrib><creatorcontrib>Ko, Hyun-Chang</creatorcontrib><creatorcontrib>Kim, Moon-Bum</creatorcontrib><creatorcontrib>Song, Ki-Hoon</creatorcontrib><creatorcontrib>Lee, Sook-Kyung</creatorcontrib><creatorcontrib>Seo, Jong-Keun</creatorcontrib><creatorcontrib>Lee, Deborah</creatorcontrib><creatorcontrib>Kim, Byung-Soo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta dermato-venereologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Tae-Wook</au><au>Mun, Je-Ho</au><au>Jwa, Seung-Wook</au><au>Song, Margaret</au><au>Kim, Hoon-Soo</au><au>Ko, Hyun-Chang</au><au>Kim, Moon-Bum</au><au>Song, Ki-Hoon</au><au>Lee, Sook-Kyung</au><au>Seo, Jong-Keun</au><au>Lee, Deborah</au><au>Kim, Byung-Soo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Proactive treatment of adult facial seborrhoeic dermatitis with 0.1% tacrolimus ointment: randomized, double-blind, vehicle-controlled, multi-centre trial</atitle><jtitle>Acta dermato-venereologica</jtitle><addtitle>Acta Derm Venereol</addtitle><date>2013-01-01</date><risdate>2013</risdate><volume>93</volume><issue>5</issue><spage>557</spage><epage>561</epage><pages>557-561</pages><issn>0001-5555</issn><eissn>1651-2057</eissn><abstract>The effectiveness of intermittent topical tacrolimus to prevent relapse in patients with stabilized facial seborrhoeic dermatitis has not been evaluated. The aim of this study was to determine whether proactive use of 0.1% tacrolimus ointment can keep adult facial seborrhoeic dermatitis in remission. A total of 75 patients who had stabilized facial seborrhoeic dermatitis after 2 weeks' (open-label induction) treatment with 0.1% tacrolimus were randomized in a double-blind fashion to treatment with 0.1% tacrolimus once a week, twice a week, or vehicle twice a week, for 10 weeks (maintenance). Significant improvement in erythema, scaling and pruritus compared with baseline was maintained during the maintenance phase in both tacrolimus groups, but not in the vehicle group. The mean recurrence rate according to global assessment was significantly higher in the tacrolimus once-weekly group than in the twice-weekly group. In conclusion, twice-weekly treatment with 0.1% tacrolimus ointment had superior effects in keeping facial seborrhoeic dermatitis in remission.</abstract><cop>Sweden</cop><pmid>23388687</pmid><doi>10.2340/00015555-1532</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Administration, Cutaneous Adult Aged Chi-Square Distribution Dermatitis, Seborrheic - diagnosis Dermatitis, Seborrheic - drug therapy Dermatologic Agents - administration & dosage Dermatologic Agents - adverse effects Double-Blind Method Drug Administration Schedule Facial Dermatoses - diagnosis Facial Dermatoses - drug therapy Female Humans Male Middle Aged Ointments Remission Induction Republic of Korea Secondary Prevention Tacrolimus - administration & dosage Tacrolimus - adverse effects Time Factors Treatment Outcome |
| title | Proactive treatment of adult facial seborrhoeic dermatitis with 0.1% tacrolimus ointment: randomized, double-blind, vehicle-controlled, multi-centre trial |
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