Elisa protocol for rapid screening of potential anti-tubercular drugs based on antigenic reactivity of mycobacterial ES-31 serine protease - a drug target supported by axenic culture of Mycobacterium tuberculosis H37 Ra strain in the presence of inhibitor

Mycobacterial ES-31 serine protease has been reported to be a drug target using protease and lipase inhibitors in axenic and macrophage cultures. Simple screening techniques are needed for rapid testing of anti-tubercular drugs. To demonstrate the usefulness of ELISA protocol based on antigenic reac...

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Veröffentlicht in:	Indian journal of tuberculosis 2013-07, Vol.60 (3), p.138-141
Hauptverfasser:	Hutke, Vinita, Wankhade, Gauri, Waghmare, Pranita J, Harinath, B C
Format:	Artikel
Sprache:	eng
Schlagworte:	Antitubercular Agents - pharmacokinetics Axenic Culture Bacterial Proteins - metabolism Drug Resistance, Microbial - physiology Enzyme-Linked Immunosorbent Assay - methods Humans Isoniazid - pharmacokinetics Lactones - pharmacokinetics Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - metabolism Serine Proteases - metabolism Tuberculosis - drug therapy
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