$Age, JAK2(V617F) and SF3B1 mutations are the main predicting factors for survival in refractory anaemia with ring sideroblasts and marked thrombocytosis$

Age, JAK2(V617F) and SF3B1 mutations are the main predicting factors for survival in refractory anaemia with ring sideroblasts and marked thrombocytosis

Refractory anaemia with ring sideroblasts (RARS) and marked thrombocytosis (RARS-T) is a provisional entity in the World Health Organisation 2008 classification and has previously been shown to have a high proportion of JAK2(V617F) (Janus Kinase 2) and SF3B1 (Splicing Factor 3B subunit 1) mutations....

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Veröffentlicht in:	Leukemia 2013-09, Vol.27 (9), p.1826-1831
Hauptverfasser:	Broséus, J, Alpermann, T, Wulfert, M, Florensa Brichs, L, Jeromin, S, Lippert, E, Rozman, M, Lifermann, F, Grossmann, V, Haferlach, T, Germing, U, Luño, E, Girodon, F, Schnittger, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Factors Aged Aged, 80 and over Anemia, Refractory - complications Anemia, Refractory - diagnosis Anemia, Refractory - genetics Anemia, Refractory - mortality Anemia, Sideroblastic - complications Chromosome Mapping Female Humans Janus Kinase 2 - genetics Karyotype Male Middle Aged Mutation Mutation Rate Phosphoproteins - genetics Prognosis Ribonucleoprotein, U2 Small Nuclear - genetics RNA Splicing Factors Thrombocytosis - complications Young Adult
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