Association of Dysglycemia and All-Cause Mortality Across the Spectrum of Coronary Artery Disease
Abstract Objective To assess the association between fasting plasma glucose (FPG) and all-cause mortality across the spectrum of coronary artery disease (CAD). Patients and Methods The study included 18,999 patients during a study period of April 1, 2004, through October 31, 2010. The primary end po...
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| creator | Yang, Shi-Wei, MD Zhou, Yu-Jie, MD Tian, Xiao-Fang, MM Pan, Guo-Zhong, MD Liu, Yu-Yang, MB Zhang, Jian, MD Guo, Zhen-Feng, MM Chen, Shu-Yan, MM Gao, Song-Tao, MM Du, Jie, PhD Jia, De-An, MD Fang, Zhe, MD Hu, Bin, MD Han, Hong-Ya, MD Gao, Fei, MD Hu, Da-Yi, MB Xu, Yu-Yun, MB |
| description | Abstract Objective To assess the association between fasting plasma glucose (FPG) and all-cause mortality across the spectrum of coronary artery disease (CAD). Patients and Methods The study included 18,999 patients during a study period of April 1, 2004, through October 31, 2010. The primary end points were in-hospital and follow-up all-cause mortality. According to the quartiles of FPG levels, patients were categorized into 4 groups: quartile 1, less than 5.1 mmol/L; quartile 2, 5.1 to less than 5.9 mmol/L; quartile 3, 5.9 to less than 7.5 mmol/L; and quartile 4, 7.5 mmol/L or greater. The conversion factor for units of plasma glucose is 1.00 mmol/L equals 18 mg/dL. Presented as mg/dL, the 4 quartile ranges of plasma glucose concentrations used in our data analysis are ≤90.0 mg/dL, 90.1-106.0 mg/dL, 106.1 mg/dL-135.0 mg/dL and ≥135.1 mg/dL. Quartile 1 was recognized as the lower glycemic group, quartiles 2 and 3 as the normoglycemic groups, and quartile 4 as the higher glycemic group. Results In patients with acute myocardial infarction, all-cause mortality for the dysglycemic groups was higher than for the normoglycemic groups: in-hospital mortality for quartiles 1, 2, 3, and 4 was 1.0%, 0.9%, 0.2%, and 1.5%, respectively ( P =.001); follow-up mortality for quartiles 1, 2, 3, and 4 was 1.7%, 0.9%, 0.3%, and 1.8%, respectively ( P |
| doi_str_mv | 10.1016/j.mayocp.2013.05.022 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1430395849</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A344842913</galeid><els_id>S002561961300459X</els_id><sourcerecordid>A344842913</sourcerecordid><originalsourceid>FETCH-LOGICAL-c515t-a7443224646d9672787e1f63cf7ec7596a9261cf4129f5e09cd6df5634318eae3</originalsourceid><addsrcrecordid>eNqFkl2L1DAUhoMo7uzoPxApCLI3rflucyOUWb9gxYtV8C7E9HQnY9qMSSv035s669feSC4OJM97cnjfg9ATgiuCiXxxqAazBHusKCaswqLClN5DG6I4LYXg8j7aYExFKYmSZ-g8pQPGuFaKP0RnlGNMeCM2yLQpBevM5MJYhL64XNKNXywMzhRm7IrW-3Jn5gTF-xAn4920FK2NIaVi2kNxfQQ7xXlYpbsQw2hifo8T5HLpEpgEj9CD3vgEj2_rFn16_erj7m159eHNu117VVpBxFSamnNGKZdcdkrWtG5qIL1ktq_B1kJJo6gktueEql4AVraTXS8k44w0YIBt0cWp7zGGbzOkSQ8uWfDejBDmpAlnmCnRcJXRZ3fQQ5jjmKdbKUkla_IwW1SdqBvjQbuxD1M0Np8uu2PDCL3L9y3jvOFUEZYFz_8S7MH4aZ-Cn1dv078gP4E_jYzQ62N0Q7ZOE6zXcPVBn8LVa7gaC53DzbKnt2PPXwbofot-pZmBlycAss_fHUSdrIPRQudizkl3wf3vh7sNrHejs8Z_hQXSH5d0ohrr63XB1v0iDGMu1Gf2A-s4yao</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1436263844</pqid></control><display><type>article</type><title>Association of Dysglycemia and All-Cause Mortality Across the Spectrum of Coronary Artery Disease</title><source>MEDLINE</source><source>ProQuest Central UK/Ireland</source><source>Alma/SFX Local Collection</source><creator>Yang, Shi-Wei, MD ; Zhou, Yu-Jie, MD ; Tian, Xiao-Fang, MM ; Pan, Guo-Zhong, MD ; Liu, Yu-Yang, MB ; Zhang, Jian, MD ; Guo, Zhen-Feng, MM ; Chen, Shu-Yan, MM ; Gao, Song-Tao, MM ; Du, Jie, PhD ; Jia, De-An, MD ; Fang, Zhe, MD ; Hu, Bin, MD ; Han, Hong-Ya, MD ; Gao, Fei, MD ; Hu, Da-Yi, MB ; Xu, Yu-Yun, MB</creator><creatorcontrib>Yang, Shi-Wei, MD ; Zhou, Yu-Jie, MD ; Tian, Xiao-Fang, MM ; Pan, Guo-Zhong, MD ; Liu, Yu-Yang, MB ; Zhang, Jian, MD ; Guo, Zhen-Feng, MM ; Chen, Shu-Yan, MM ; Gao, Song-Tao, MM ; Du, Jie, PhD ; Jia, De-An, MD ; Fang, Zhe, MD ; Hu, Bin, MD ; Han, Hong-Ya, MD ; Gao, Fei, MD ; Hu, Da-Yi, MB ; Xu, Yu-Yun, MB ; Beijing Heart and Metabolism Survey Study Group</creatorcontrib><description>Abstract Objective To assess the association between fasting plasma glucose (FPG) and all-cause mortality across the spectrum of coronary artery disease (CAD). Patients and Methods The study included 18,999 patients during a study period of April 1, 2004, through October 31, 2010. The primary end points were in-hospital and follow-up all-cause mortality. According to the quartiles of FPG levels, patients were categorized into 4 groups: quartile 1, less than 5.1 mmol/L; quartile 2, 5.1 to less than 5.9 mmol/L; quartile 3, 5.9 to less than 7.5 mmol/L; and quartile 4, 7.5 mmol/L or greater. The conversion factor for units of plasma glucose is 1.00 mmol/L equals 18 mg/dL. Presented as mg/dL, the 4 quartile ranges of plasma glucose concentrations used in our data analysis are ≤90.0 mg/dL, 90.1-106.0 mg/dL, 106.1 mg/dL-135.0 mg/dL and ≥135.1 mg/dL. Quartile 1 was recognized as the lower glycemic group, quartiles 2 and 3 as the normoglycemic groups, and quartile 4 as the higher glycemic group. Results In patients with acute myocardial infarction, all-cause mortality for the dysglycemic groups was higher than for the normoglycemic groups: in-hospital mortality for quartiles 1, 2, 3, and 4 was 1.0%, 0.9%, 0.2%, and 1.5%, respectively ( P =.001); follow-up mortality for quartiles 1, 2, 3, and 4 was 1.7%, 0.9%, 0.3%, and 1.8%, respectively ( P <.001). In patients with stable CAD, no significant differences in mortality were found among groups. However, in patients with unstable angina pectoris, the normoglycemic groups had lower follow-up mortality and roughly equal in-hospital mortality compared with the dysglycemic groups. After adjusting for confounding factors, this observation persisted. Conclusion The association between lower FPG level and mortality differed across the spectrum of CAD. In patients with acute myocardial infarction, there was a U-shaped relationship. In patients with stable CAD or unstable angina pectoris, mildly to moderately decreasing FPG level was associated with neither higher nor lower all-cause mortality.</description><identifier>ISSN: 0025-6196</identifier><identifier>EISSN: 1942-5546</identifier><identifier>DOI: 10.1016/j.mayocp.2013.05.022</identifier><identifier>PMID: 24001485</identifier><identifier>CODEN: MACPAJ</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Angina Pectoris - blood ; Angina Pectoris - mortality ; Angina, Unstable - blood ; Angina, Unstable - mortality ; Blood Glucose - analysis ; Comparative analysis ; Coronary Artery Disease - blood ; Coronary Artery Disease - mortality ; Coronary heart disease ; Distribution ; Female ; Hospital Mortality ; Humans ; Internal Medicine ; Male ; Metabolic diseases ; Middle Aged ; Mortality ; Myocardial Infarction - blood ; Myocardial Infarction - mortality ; Retrospective Studies ; United Kingdom ; Young Adult</subject><ispartof>Mayo Clinic proceedings, 2013-09, Vol.88 (9), p.930-941</ispartof><rights>Mayo Foundation for Medical Education and Research</rights><rights>2013 Mayo Foundation for Medical Education and Research</rights><rights>Copyright © 2013 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.</rights><rights>COPYRIGHT 2013 Elsevier, Inc.</rights><rights>Copyright Mayo Foundation for Medical Education and Research Sep 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c515t-a7443224646d9672787e1f63cf7ec7596a9261cf4129f5e09cd6df5634318eae3</citedby><cites>FETCH-LOGICAL-c515t-a7443224646d9672787e1f63cf7ec7596a9261cf4129f5e09cd6df5634318eae3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1436263844?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24001485$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, Shi-Wei, MD</creatorcontrib><creatorcontrib>Zhou, Yu-Jie, MD</creatorcontrib><creatorcontrib>Tian, Xiao-Fang, MM</creatorcontrib><creatorcontrib>Pan, Guo-Zhong, MD</creatorcontrib><creatorcontrib>Liu, Yu-Yang, MB</creatorcontrib><creatorcontrib>Zhang, Jian, MD</creatorcontrib><creatorcontrib>Guo, Zhen-Feng, MM</creatorcontrib><creatorcontrib>Chen, Shu-Yan, MM</creatorcontrib><creatorcontrib>Gao, Song-Tao, MM</creatorcontrib><creatorcontrib>Du, Jie, PhD</creatorcontrib><creatorcontrib>Jia, De-An, MD</creatorcontrib><creatorcontrib>Fang, Zhe, MD</creatorcontrib><creatorcontrib>Hu, Bin, MD</creatorcontrib><creatorcontrib>Han, Hong-Ya, MD</creatorcontrib><creatorcontrib>Gao, Fei, MD</creatorcontrib><creatorcontrib>Hu, Da-Yi, MB</creatorcontrib><creatorcontrib>Xu, Yu-Yun, MB</creatorcontrib><creatorcontrib>Beijing Heart and Metabolism Survey Study Group</creatorcontrib><title>Association of Dysglycemia and All-Cause Mortality Across the Spectrum of Coronary Artery Disease</title><title>Mayo Clinic proceedings</title><addtitle>Mayo Clin Proc</addtitle><description>Abstract Objective To assess the association between fasting plasma glucose (FPG) and all-cause mortality across the spectrum of coronary artery disease (CAD). Patients and Methods The study included 18,999 patients during a study period of April 1, 2004, through October 31, 2010. The primary end points were in-hospital and follow-up all-cause mortality. According to the quartiles of FPG levels, patients were categorized into 4 groups: quartile 1, less than 5.1 mmol/L; quartile 2, 5.1 to less than 5.9 mmol/L; quartile 3, 5.9 to less than 7.5 mmol/L; and quartile 4, 7.5 mmol/L or greater. The conversion factor for units of plasma glucose is 1.00 mmol/L equals 18 mg/dL. Presented as mg/dL, the 4 quartile ranges of plasma glucose concentrations used in our data analysis are ≤90.0 mg/dL, 90.1-106.0 mg/dL, 106.1 mg/dL-135.0 mg/dL and ≥135.1 mg/dL. Quartile 1 was recognized as the lower glycemic group, quartiles 2 and 3 as the normoglycemic groups, and quartile 4 as the higher glycemic group. Results In patients with acute myocardial infarction, all-cause mortality for the dysglycemic groups was higher than for the normoglycemic groups: in-hospital mortality for quartiles 1, 2, 3, and 4 was 1.0%, 0.9%, 0.2%, and 1.5%, respectively ( P =.001); follow-up mortality for quartiles 1, 2, 3, and 4 was 1.7%, 0.9%, 0.3%, and 1.8%, respectively ( P <.001). In patients with stable CAD, no significant differences in mortality were found among groups. However, in patients with unstable angina pectoris, the normoglycemic groups had lower follow-up mortality and roughly equal in-hospital mortality compared with the dysglycemic groups. After adjusting for confounding factors, this observation persisted. Conclusion The association between lower FPG level and mortality differed across the spectrum of CAD. In patients with acute myocardial infarction, there was a U-shaped relationship. In patients with stable CAD or unstable angina pectoris, mildly to moderately decreasing FPG level was associated with neither higher nor lower all-cause mortality.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Angina Pectoris - blood</subject><subject>Angina Pectoris - mortality</subject><subject>Angina, Unstable - blood</subject><subject>Angina, Unstable - mortality</subject><subject>Blood Glucose - analysis</subject><subject>Comparative analysis</subject><subject>Coronary Artery Disease - blood</subject><subject>Coronary Artery Disease - mortality</subject><subject>Coronary heart disease</subject><subject>Distribution</subject><subject>Female</subject><subject>Hospital Mortality</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Metabolic diseases</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Myocardial Infarction - blood</subject><subject>Myocardial Infarction - mortality</subject><subject>Retrospective Studies</subject><subject>United Kingdom</subject><subject>Young Adult</subject><issn>0025-6196</issn><issn>1942-5546</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkl2L1DAUhoMo7uzoPxApCLI3rflucyOUWb9gxYtV8C7E9HQnY9qMSSv035s669feSC4OJM97cnjfg9ATgiuCiXxxqAazBHusKCaswqLClN5DG6I4LYXg8j7aYExFKYmSZ-g8pQPGuFaKP0RnlGNMeCM2yLQpBevM5MJYhL64XNKNXywMzhRm7IrW-3Jn5gTF-xAn4920FK2NIaVi2kNxfQQ7xXlYpbsQw2hifo8T5HLpEpgEj9CD3vgEj2_rFn16_erj7m159eHNu117VVpBxFSamnNGKZdcdkrWtG5qIL1ktq_B1kJJo6gktueEql4AVraTXS8k44w0YIBt0cWp7zGGbzOkSQ8uWfDejBDmpAlnmCnRcJXRZ3fQQ5jjmKdbKUkla_IwW1SdqBvjQbuxD1M0Np8uu2PDCL3L9y3jvOFUEZYFz_8S7MH4aZ-Cn1dv078gP4E_jYzQ62N0Q7ZOE6zXcPVBn8LVa7gaC53DzbKnt2PPXwbofot-pZmBlycAss_fHUSdrIPRQudizkl3wf3vh7sNrHejs8Z_hQXSH5d0ohrr63XB1v0iDGMu1Gf2A-s4yao</recordid><startdate>20130901</startdate><enddate>20130901</enddate><creator>Yang, Shi-Wei, MD</creator><creator>Zhou, Yu-Jie, MD</creator><creator>Tian, Xiao-Fang, MM</creator><creator>Pan, Guo-Zhong, MD</creator><creator>Liu, Yu-Yang, MB</creator><creator>Zhang, Jian, MD</creator><creator>Guo, Zhen-Feng, MM</creator><creator>Chen, Shu-Yan, MM</creator><creator>Gao, Song-Tao, MM</creator><creator>Du, Jie, PhD</creator><creator>Jia, De-An, MD</creator><creator>Fang, Zhe, MD</creator><creator>Hu, Bin, MD</creator><creator>Han, Hong-Ya, MD</creator><creator>Gao, Fei, MD</creator><creator>Hu, Da-Yi, MB</creator><creator>Xu, Yu-Yun, MB</creator><general>Elsevier Inc</general><general>Elsevier, Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>4U-</scope><scope>7RV</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>20130901</creationdate><title>Association of Dysglycemia and All-Cause Mortality Across the Spectrum of Coronary Artery Disease</title><author>Yang, Shi-Wei, MD ; Zhou, Yu-Jie, MD ; Tian, Xiao-Fang, MM ; Pan, Guo-Zhong, MD ; Liu, Yu-Yang, MB ; Zhang, Jian, MD ; Guo, Zhen-Feng, MM ; Chen, Shu-Yan, MM ; Gao, Song-Tao, MM ; Du, Jie, PhD ; Jia, De-An, MD ; Fang, Zhe, MD ; Hu, Bin, MD ; Han, Hong-Ya, MD ; Gao, Fei, MD ; Hu, Da-Yi, MB ; Xu, Yu-Yun, MB</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c515t-a7443224646d9672787e1f63cf7ec7596a9261cf4129f5e09cd6df5634318eae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Angina Pectoris - blood</topic><topic>Angina Pectoris - mortality</topic><topic>Angina, Unstable - blood</topic><topic>Angina, Unstable - mortality</topic><topic>Blood Glucose - analysis</topic><topic>Comparative analysis</topic><topic>Coronary Artery Disease - blood</topic><topic>Coronary Artery Disease - mortality</topic><topic>Coronary heart disease</topic><topic>Distribution</topic><topic>Female</topic><topic>Hospital Mortality</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Metabolic diseases</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Myocardial Infarction - blood</topic><topic>Myocardial Infarction - mortality</topic><topic>Retrospective Studies</topic><topic>United Kingdom</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Shi-Wei, MD</creatorcontrib><creatorcontrib>Zhou, Yu-Jie, MD</creatorcontrib><creatorcontrib>Tian, Xiao-Fang, MM</creatorcontrib><creatorcontrib>Pan, Guo-Zhong, MD</creatorcontrib><creatorcontrib>Liu, Yu-Yang, MB</creatorcontrib><creatorcontrib>Zhang, Jian, MD</creatorcontrib><creatorcontrib>Guo, Zhen-Feng, MM</creatorcontrib><creatorcontrib>Chen, Shu-Yan, MM</creatorcontrib><creatorcontrib>Gao, Song-Tao, MM</creatorcontrib><creatorcontrib>Du, Jie, PhD</creatorcontrib><creatorcontrib>Jia, De-An, MD</creatorcontrib><creatorcontrib>Fang, Zhe, MD</creatorcontrib><creatorcontrib>Hu, Bin, MD</creatorcontrib><creatorcontrib>Han, Hong-Ya, MD</creatorcontrib><creatorcontrib>Gao, Fei, MD</creatorcontrib><creatorcontrib>Hu, Da-Yi, MB</creatorcontrib><creatorcontrib>Xu, Yu-Yun, MB</creatorcontrib><creatorcontrib>Beijing Heart and Metabolism Survey Study Group</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>University Readers</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Mayo Clinic proceedings</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Shi-Wei, MD</au><au>Zhou, Yu-Jie, MD</au><au>Tian, Xiao-Fang, MM</au><au>Pan, Guo-Zhong, MD</au><au>Liu, Yu-Yang, MB</au><au>Zhang, Jian, MD</au><au>Guo, Zhen-Feng, MM</au><au>Chen, Shu-Yan, MM</au><au>Gao, Song-Tao, MM</au><au>Du, Jie, PhD</au><au>Jia, De-An, MD</au><au>Fang, Zhe, MD</au><au>Hu, Bin, MD</au><au>Han, Hong-Ya, MD</au><au>Gao, Fei, MD</au><au>Hu, Da-Yi, MB</au><au>Xu, Yu-Yun, MB</au><aucorp>Beijing Heart and Metabolism Survey Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of Dysglycemia and All-Cause Mortality Across the Spectrum of Coronary Artery Disease</atitle><jtitle>Mayo Clinic proceedings</jtitle><addtitle>Mayo Clin Proc</addtitle><date>2013-09-01</date><risdate>2013</risdate><volume>88</volume><issue>9</issue><spage>930</spage><epage>941</epage><pages>930-941</pages><issn>0025-6196</issn><eissn>1942-5546</eissn><coden>MACPAJ</coden><abstract>Abstract Objective To assess the association between fasting plasma glucose (FPG) and all-cause mortality across the spectrum of coronary artery disease (CAD). Patients and Methods The study included 18,999 patients during a study period of April 1, 2004, through October 31, 2010. The primary end points were in-hospital and follow-up all-cause mortality. According to the quartiles of FPG levels, patients were categorized into 4 groups: quartile 1, less than 5.1 mmol/L; quartile 2, 5.1 to less than 5.9 mmol/L; quartile 3, 5.9 to less than 7.5 mmol/L; and quartile 4, 7.5 mmol/L or greater. The conversion factor for units of plasma glucose is 1.00 mmol/L equals 18 mg/dL. Presented as mg/dL, the 4 quartile ranges of plasma glucose concentrations used in our data analysis are ≤90.0 mg/dL, 90.1-106.0 mg/dL, 106.1 mg/dL-135.0 mg/dL and ≥135.1 mg/dL. Quartile 1 was recognized as the lower glycemic group, quartiles 2 and 3 as the normoglycemic groups, and quartile 4 as the higher glycemic group. Results In patients with acute myocardial infarction, all-cause mortality for the dysglycemic groups was higher than for the normoglycemic groups: in-hospital mortality for quartiles 1, 2, 3, and 4 was 1.0%, 0.9%, 0.2%, and 1.5%, respectively ( P =.001); follow-up mortality for quartiles 1, 2, 3, and 4 was 1.7%, 0.9%, 0.3%, and 1.8%, respectively ( P <.001). In patients with stable CAD, no significant differences in mortality were found among groups. However, in patients with unstable angina pectoris, the normoglycemic groups had lower follow-up mortality and roughly equal in-hospital mortality compared with the dysglycemic groups. After adjusting for confounding factors, this observation persisted. Conclusion The association between lower FPG level and mortality differed across the spectrum of CAD. In patients with acute myocardial infarction, there was a U-shaped relationship. In patients with stable CAD or unstable angina pectoris, mildly to moderately decreasing FPG level was associated with neither higher nor lower all-cause mortality.</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>24001485</pmid><doi>10.1016/j.mayocp.2013.05.022</doi><tpages>12</tpages></addata></record> |
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| ispartof | Mayo Clinic proceedings, 2013-09, Vol.88 (9), p.930-941 |
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| subjects | Adult Aged Aged, 80 and over Angina Pectoris - blood Angina Pectoris - mortality Angina, Unstable - blood Angina, Unstable - mortality Blood Glucose - analysis Comparative analysis Coronary Artery Disease - blood Coronary Artery Disease - mortality Coronary heart disease Distribution Female Hospital Mortality Humans Internal Medicine Male Metabolic diseases Middle Aged Mortality Myocardial Infarction - blood Myocardial Infarction - mortality Retrospective Studies United Kingdom Young Adult |
| title | Association of Dysglycemia and All-Cause Mortality Across the Spectrum of Coronary Artery Disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T17%3A42%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20of%20Dysglycemia%20and%20All-Cause%20Mortality%20Across%20the%20Spectrum%20of%20Coronary%20Artery%20Disease&rft.jtitle=Mayo%20Clinic%20proceedings&rft.au=Yang,%20Shi-Wei,%20MD&rft.aucorp=Beijing%20Heart%20and%20Metabolism%20Survey%20Study%20Group&rft.date=2013-09-01&rft.volume=88&rft.issue=9&rft.spage=930&rft.epage=941&rft.pages=930-941&rft.issn=0025-6196&rft.eissn=1942-5546&rft.coden=MACPAJ&rft_id=info:doi/10.1016/j.mayocp.2013.05.022&rft_dat=%3Cgale_proqu%3EA344842913%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1436263844&rft_id=info:pmid/24001485&rft_galeid=A344842913&rft_els_id=S002561961300459X&rfr_iscdi=true |