Decreased serum selenium in alcoholics as related to liver structure and function
Serum selenium was evaluated in relation to hepatic structure and function in 46 alcoholics with diagnostic liver biopsy classified into 4 groups by hepatic histology. Their serum selenium concentration varied from 12 to 88 µg/1 and was lower (p < 0.001) in all groups of alcoholics, ie patients w...
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| Veröffentlicht in: | The American journal of clinical nutrition 1985-07, Vol.42 (1), p.147-151 |
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| creator | Korpela, H Kumpulainen, J Luoma, PV Arranto, AJ Sotaniemi, EA |
| description | Serum selenium was evaluated in relation to hepatic structure and function in 46 alcoholics with diagnostic liver biopsy classified into 4 groups by hepatic histology. Their serum selenium concentration varied from 12 to 88 µg/1 and was lower (p < 0.001) in all groups of alcoholics, ie patients with normal liver (53.0 ± 20.7 µg/1, mean ± SD), fatty liver (55.8 ± 21.2 µg/1), alcoholic hepatitis (46.0 ±14.1 µg/1), and cirrhosis (41.1 ± 12.8 µg/1), than in 25 healthy controls (88.7 ± 11.0 µg/l). Serum selenium level was related to the severity of liver disease, and most reduced in subjects with decompensated alcoholic cirrhosis. Their serum selenium level (29.2 ± 13.7 µg/l) was below (p < 0.05) that obtained in alcoholics with normal liver and fatty liver respectively. Both inadequate dietary selenium intake and alcohol-induced changes in hepatic structure and function may have contributed to the decrease of serum selenium in the subjects studied. |
| doi_str_mv | 10.1093/ajcn/42.1.147 |
| format | Article |
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Their serum selenium concentration varied from 12 to 88 µg/1 and was lower (p < 0.001) in all groups of alcoholics, ie patients with normal liver (53.0 ± 20.7 µg/1, mean ± SD), fatty liver (55.8 ± 21.2 µg/1), alcoholic hepatitis (46.0 ±14.1 µg/1), and cirrhosis (41.1 ± 12.8 µg/1), than in 25 healthy controls (88.7 ± 11.0 µg/l). Serum selenium level was related to the severity of liver disease, and most reduced in subjects with decompensated alcoholic cirrhosis. Their serum selenium level (29.2 ± 13.7 µg/l) was below (p < 0.05) that obtained in alcoholics with normal liver and fatty liver respectively. Both inadequate dietary selenium intake and alcohol-induced changes in hepatic structure and function may have contributed to the decrease of serum selenium in the subjects studied.</description><identifier>ISSN: 0002-9165</identifier><identifier>EISSN: 1938-3207</identifier><identifier>DOI: 10.1093/ajcn/42.1.147</identifier><identifier>PMID: 4014064</identifier><identifier>CODEN: AJCNAC</identifier><language>eng</language><publisher>Bethesda, MD: Elsevier Inc</publisher><subject>Adult ; Aged ; alcohol ; alcohol abuse ; alcoholic liver disease ; Alcoholism and acute alcohol poisoning ; Biological and medical sciences ; cirrhosis ; Diagnosis, Differential ; fatty liver ; Female ; hepatitis ; Humans ; Liver - pathology ; Liver Diseases, Alcoholic - blood ; Liver Diseases, Alcoholic - pathology ; Liver Diseases, Alcoholic - physiopathology ; Liver Function Tests ; liver histology ; Male ; Medical sciences ; metabolic diseases ; Middle Aged ; mineral metabolism ; nutrient deficiencies ; risk ; Selenium ; Selenium - blood ; Toxicology</subject><ispartof>The American journal of clinical nutrition, 1985-07, Vol.42 (1), p.147-151</ispartof><rights>1985 American Society for Nutrition.</rights><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c525t-cf4190e31ff4c2431b41290d66b91b7684d98ddd5b462d7332e29ddfd7587f683</citedby><cites>FETCH-LOGICAL-c525t-cf4190e31ff4c2431b41290d66b91b7684d98ddd5b462d7332e29ddfd7587f683</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8583109$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4014064$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Korpela, H</creatorcontrib><creatorcontrib>Kumpulainen, J</creatorcontrib><creatorcontrib>Luoma, PV</creatorcontrib><creatorcontrib>Arranto, AJ</creatorcontrib><creatorcontrib>Sotaniemi, EA</creatorcontrib><title>Decreased serum selenium in alcoholics as related to liver structure and function</title><title>The American journal of clinical nutrition</title><addtitle>Am J Clin Nutr</addtitle><description>Serum selenium was evaluated in relation to hepatic structure and function in 46 alcoholics with diagnostic liver biopsy classified into 4 groups by hepatic histology. Their serum selenium concentration varied from 12 to 88 µg/1 and was lower (p < 0.001) in all groups of alcoholics, ie patients with normal liver (53.0 ± 20.7 µg/1, mean ± SD), fatty liver (55.8 ± 21.2 µg/1), alcoholic hepatitis (46.0 ±14.1 µg/1), and cirrhosis (41.1 ± 12.8 µg/1), than in 25 healthy controls (88.7 ± 11.0 µg/l). Serum selenium level was related to the severity of liver disease, and most reduced in subjects with decompensated alcoholic cirrhosis. Their serum selenium level (29.2 ± 13.7 µg/l) was below (p < 0.05) that obtained in alcoholics with normal liver and fatty liver respectively. Both inadequate dietary selenium intake and alcohol-induced changes in hepatic structure and function may have contributed to the decrease of serum selenium in the subjects studied.</description><subject>Adult</subject><subject>Aged</subject><subject>alcohol</subject><subject>alcohol abuse</subject><subject>alcoholic liver disease</subject><subject>Alcoholism and acute alcohol poisoning</subject><subject>Biological and medical sciences</subject><subject>cirrhosis</subject><subject>Diagnosis, Differential</subject><subject>fatty liver</subject><subject>Female</subject><subject>hepatitis</subject><subject>Humans</subject><subject>Liver - pathology</subject><subject>Liver Diseases, Alcoholic - blood</subject><subject>Liver Diseases, Alcoholic - pathology</subject><subject>Liver Diseases, Alcoholic - physiopathology</subject><subject>Liver Function Tests</subject><subject>liver histology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>metabolic diseases</subject><subject>Middle Aged</subject><subject>mineral metabolism</subject><subject>nutrient deficiencies</subject><subject>risk</subject><subject>Selenium</subject><subject>Selenium - blood</subject><subject>Toxicology</subject><issn>0002-9165</issn><issn>1938-3207</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10M9rHCEUB3ApDel2k2OPpXMovc3Gp46Ox5L0RyBQSpuzOPpsDa6T6kyg_31ddsmtFxXexy-PLyFvgO6Aan5lH1y-EmwHOxDqBdmA5mPPGVUvyYZSynoNcnhFXtf6QCkwMcpzci4oCCrFhny_QVfQVvRdxbLu25kwx_aIubPJzb_nFF3tbO0KJrs0t8xdik9YurqU1S1rwc5m34U1uyXO-YKcBZsqXp7uLbn__Onn9df-7tuX2-uPd70b2LD0LgjQFDmEIBwTHCYBTFMv5aRhUnIUXo_e-2ESknnFOUOmvQ9eDaMKcuRb8uGY-1jmPyvWxexjdZiSzTiv1YDglEsNDfZH6Mpca8FgHkvc2_LXADWHCs2hQiOYgfZJNf_2FLxOe_TP-tRZm78_zW11NoVis4v1mY3DyA-pW_LuyIKdjf1VGrn_wSjwFsOVErIJdRTYanqKWEx1EbNDHwu6xfg5_mfFf37JlbA</recordid><startdate>198507</startdate><enddate>198507</enddate><creator>Korpela, H</creator><creator>Kumpulainen, J</creator><creator>Luoma, PV</creator><creator>Arranto, AJ</creator><creator>Sotaniemi, EA</creator><general>Elsevier Inc</general><general>American Society for Clinical Nutrition</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>198507</creationdate><title>Decreased serum selenium in alcoholics as related to liver structure and function</title><author>Korpela, H ; Kumpulainen, J ; Luoma, PV ; Arranto, AJ ; Sotaniemi, EA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c525t-cf4190e31ff4c2431b41290d66b91b7684d98ddd5b462d7332e29ddfd7587f683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Adult</topic><topic>Aged</topic><topic>alcohol</topic><topic>alcohol abuse</topic><topic>alcoholic liver disease</topic><topic>Alcoholism and acute alcohol poisoning</topic><topic>Biological and medical sciences</topic><topic>cirrhosis</topic><topic>Diagnosis, Differential</topic><topic>fatty liver</topic><topic>Female</topic><topic>hepatitis</topic><topic>Humans</topic><topic>Liver - pathology</topic><topic>Liver Diseases, Alcoholic - blood</topic><topic>Liver Diseases, Alcoholic - pathology</topic><topic>Liver Diseases, Alcoholic - physiopathology</topic><topic>Liver Function Tests</topic><topic>liver histology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>metabolic diseases</topic><topic>Middle Aged</topic><topic>mineral metabolism</topic><topic>nutrient deficiencies</topic><topic>risk</topic><topic>Selenium</topic><topic>Selenium - blood</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Korpela, H</creatorcontrib><creatorcontrib>Kumpulainen, J</creatorcontrib><creatorcontrib>Luoma, PV</creatorcontrib><creatorcontrib>Arranto, AJ</creatorcontrib><creatorcontrib>Sotaniemi, EA</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>The American journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Korpela, H</au><au>Kumpulainen, J</au><au>Luoma, PV</au><au>Arranto, AJ</au><au>Sotaniemi, EA</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Decreased serum selenium in alcoholics as related to liver structure and function</atitle><jtitle>The American journal of clinical nutrition</jtitle><addtitle>Am J Clin Nutr</addtitle><date>1985-07</date><risdate>1985</risdate><volume>42</volume><issue>1</issue><spage>147</spage><epage>151</epage><pages>147-151</pages><issn>0002-9165</issn><eissn>1938-3207</eissn><coden>AJCNAC</coden><abstract>Serum selenium was evaluated in relation to hepatic structure and function in 46 alcoholics with diagnostic liver biopsy classified into 4 groups by hepatic histology. Their serum selenium concentration varied from 12 to 88 µg/1 and was lower (p < 0.001) in all groups of alcoholics, ie patients with normal liver (53.0 ± 20.7 µg/1, mean ± SD), fatty liver (55.8 ± 21.2 µg/1), alcoholic hepatitis (46.0 ±14.1 µg/1), and cirrhosis (41.1 ± 12.8 µg/1), than in 25 healthy controls (88.7 ± 11.0 µg/l). Serum selenium level was related to the severity of liver disease, and most reduced in subjects with decompensated alcoholic cirrhosis. Their serum selenium level (29.2 ± 13.7 µg/l) was below (p < 0.05) that obtained in alcoholics with normal liver and fatty liver respectively. Both inadequate dietary selenium intake and alcohol-induced changes in hepatic structure and function may have contributed to the decrease of serum selenium in the subjects studied.</abstract><cop>Bethesda, MD</cop><pub>Elsevier Inc</pub><pmid>4014064</pmid><doi>10.1093/ajcn/42.1.147</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged alcohol alcohol abuse alcoholic liver disease Alcoholism and acute alcohol poisoning Biological and medical sciences cirrhosis Diagnosis, Differential fatty liver Female hepatitis Humans Liver - pathology Liver Diseases, Alcoholic - blood Liver Diseases, Alcoholic - pathology Liver Diseases, Alcoholic - physiopathology Liver Function Tests liver histology Male Medical sciences metabolic diseases Middle Aged mineral metabolism nutrient deficiencies risk Selenium Selenium - blood Toxicology |
| title | Decreased serum selenium in alcoholics as related to liver structure and function |
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