Evaluation of the association of prostate cancer-specific anxiety with sexual function, depression and cancer aggressiveness in men 1 year following surgical treatment for localized prostate cancer
Background Cancer‐specific anxiety (CSA) can affect treatment decisions and is common in men following surgery for prostate cancer (PCa). We hypothesized that CSA is also associated with factors affecting quality of life. Herein, we examine the association of CSA with psychosocial factors and PCa ag...
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| Veröffentlicht in: | Psycho-oncology (Chichester, England) England), 2013-06, Vol.22 (6), p.1328-1335 |
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| creator | Tavlarides, Andrea M. Ames, Steven C. Diehl, Nancy N. Joseph, Richard W. Castle, Erik P. Thiel, David D. Broderick, Gregory A. Parker, Alexander S. |
| description | Background
Cancer‐specific anxiety (CSA) can affect treatment decisions and is common in men following surgery for prostate cancer (PCa). We hypothesized that CSA is also associated with factors affecting quality of life. Herein, we examine the association of CSA with psychosocial factors and PCa aggressiveness in a cohort of men 1 year after prostatectomy for localized PCa.
Methods
From our prospective PCa Registry, we identified 365 men who underwent prostatectomy for localized PCa who completed the Memorial Anxiety Scale for Prostate Cancer (MAX‐PC) and Expanded Prostate Cancer Index Composite at 1‐year follow‐up. We evaluated the association of scores on the MAX‐PC with demographics, clinicopathologic features, sexual function, and depression scores using Wilcoxon Rank Sum and Kendall's tau correlation tests.
Results
Higher scores on the MAX‐PC (i.e., higher anxiety) are associated with younger age (p |
| doi_str_mv | 10.1002/pon.3138 |
| format | Article |
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Cancer‐specific anxiety (CSA) can affect treatment decisions and is common in men following surgery for prostate cancer (PCa). We hypothesized that CSA is also associated with factors affecting quality of life. Herein, we examine the association of CSA with psychosocial factors and PCa aggressiveness in a cohort of men 1 year after prostatectomy for localized PCa.
Methods
From our prospective PCa Registry, we identified 365 men who underwent prostatectomy for localized PCa who completed the Memorial Anxiety Scale for Prostate Cancer (MAX‐PC) and Expanded Prostate Cancer Index Composite at 1‐year follow‐up. We evaluated the association of scores on the MAX‐PC with demographics, clinicopathologic features, sexual function, and depression scores using Wilcoxon Rank Sum and Kendall's tau correlation tests.
Results
Higher scores on the MAX‐PC (i.e., higher anxiety) are associated with younger age (p < 0.01) and non‐Caucasian race (p < 0.01). Men with higher MAX‐PC scores also reported poor sexual satisfaction/function (p < 0.01) and increasing depressive symptoms (p < 0.01). Finally, although higher anxiety is associated with several pathologic features of aggressiveness (stage, positive margins, PSA at 1 year; all p‐values < 0.01), we noted several men with clinically indolent disease who reported significant anxiety.
Conclusions
Our data suggest that higher levels of CSA are associated with poor sexual function and increased depressive symptoms 1 year after prostatectomy. Moreover, we noted demographic and pathologic features associated with higher CSA as well. If confirmed, our data support development of models to predict men at high risk of CSA following PCa surgery and targeted referral for additional counseling. Copyright © 2012 John Wiley & Sons, Ltd.]]></description><identifier>ISSN: 1057-9249</identifier><identifier>EISSN: 1099-1611</identifier><identifier>DOI: 10.1002/pon.3138</identifier><identifier>PMID: 22855322</identifier><identifier>CODEN: POJCEE</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Age Factors ; Aged ; Anxiety ; Anxiety - diagnosis ; Anxiety - etiology ; Anxiety - psychology ; Anxiety-Depression ; Depression ; Depression - diagnosis ; Depression - etiology ; Depression - psychology ; Follow-Up Studies ; Humans ; Male ; Men ; Middle Aged ; oncology ; Postoperative anxiety ; Prospective Studies ; Prostate cancer ; Prostatectomy ; Prostatic cancer ; Prostatic Neoplasms - complications ; Prostatic Neoplasms - psychology ; Prostatic Neoplasms - surgery ; Quality of Life ; Severity of Illness Index ; Sexual behavior ; Sexual Dysfunction, Physiological - etiology ; Sexual Dysfunctions, Psychological - etiology ; Social psychology ; Statistics, Nonparametric ; Stress, Psychological ; Surgery ; Surveys and Questionnaires</subject><ispartof>Psycho-oncology (Chichester, England), 2013-06, Vol.22 (6), p.1328-1335</ispartof><rights>Copyright © 2012 John Wiley & Sons, Ltd.</rights><rights>Copyright Wiley Subscription Services, Inc. Jun 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3688-2812b922e98ed1683af7bb0e8726d3753ffbd6a18d19ca28f9ee4a65eecd21a3</citedby><cites>FETCH-LOGICAL-c3688-2812b922e98ed1683af7bb0e8726d3753ffbd6a18d19ca28f9ee4a65eecd21a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fpon.3138$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fpon.3138$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,30978,30979,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22855322$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tavlarides, Andrea M.</creatorcontrib><creatorcontrib>Ames, Steven C.</creatorcontrib><creatorcontrib>Diehl, Nancy N.</creatorcontrib><creatorcontrib>Joseph, Richard W.</creatorcontrib><creatorcontrib>Castle, Erik P.</creatorcontrib><creatorcontrib>Thiel, David D.</creatorcontrib><creatorcontrib>Broderick, Gregory A.</creatorcontrib><creatorcontrib>Parker, Alexander S.</creatorcontrib><title>Evaluation of the association of prostate cancer-specific anxiety with sexual function, depression and cancer aggressiveness in men 1 year following surgical treatment for localized prostate cancer</title><title>Psycho-oncology (Chichester, England)</title><addtitle>Psycho-Oncology</addtitle><description><![CDATA[Background
Cancer‐specific anxiety (CSA) can affect treatment decisions and is common in men following surgery for prostate cancer (PCa). We hypothesized that CSA is also associated with factors affecting quality of life. Herein, we examine the association of CSA with psychosocial factors and PCa aggressiveness in a cohort of men 1 year after prostatectomy for localized PCa.
Methods
From our prospective PCa Registry, we identified 365 men who underwent prostatectomy for localized PCa who completed the Memorial Anxiety Scale for Prostate Cancer (MAX‐PC) and Expanded Prostate Cancer Index Composite at 1‐year follow‐up. We evaluated the association of scores on the MAX‐PC with demographics, clinicopathologic features, sexual function, and depression scores using Wilcoxon Rank Sum and Kendall's tau correlation tests.
Results
Higher scores on the MAX‐PC (i.e., higher anxiety) are associated with younger age (p < 0.01) and non‐Caucasian race (p < 0.01). Men with higher MAX‐PC scores also reported poor sexual satisfaction/function (p < 0.01) and increasing depressive symptoms (p < 0.01). Finally, although higher anxiety is associated with several pathologic features of aggressiveness (stage, positive margins, PSA at 1 year; all p‐values < 0.01), we noted several men with clinically indolent disease who reported significant anxiety.
Conclusions
Our data suggest that higher levels of CSA are associated with poor sexual function and increased depressive symptoms 1 year after prostatectomy. Moreover, we noted demographic and pathologic features associated with higher CSA as well. If confirmed, our data support development of models to predict men at high risk of CSA following PCa surgery and targeted referral for additional counseling. Copyright © 2012 John Wiley & Sons, Ltd.]]></description><subject>Age Factors</subject><subject>Aged</subject><subject>Anxiety</subject><subject>Anxiety - diagnosis</subject><subject>Anxiety - etiology</subject><subject>Anxiety - psychology</subject><subject>Anxiety-Depression</subject><subject>Depression</subject><subject>Depression - diagnosis</subject><subject>Depression - etiology</subject><subject>Depression - psychology</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Male</subject><subject>Men</subject><subject>Middle Aged</subject><subject>oncology</subject><subject>Postoperative anxiety</subject><subject>Prospective Studies</subject><subject>Prostate cancer</subject><subject>Prostatectomy</subject><subject>Prostatic cancer</subject><subject>Prostatic Neoplasms - complications</subject><subject>Prostatic Neoplasms - psychology</subject><subject>Prostatic Neoplasms - surgery</subject><subject>Quality of Life</subject><subject>Severity of Illness Index</subject><subject>Sexual behavior</subject><subject>Sexual Dysfunction, Physiological - etiology</subject><subject>Sexual Dysfunctions, Psychological - etiology</subject><subject>Social psychology</subject><subject>Statistics, Nonparametric</subject><subject>Stress, Psychological</subject><subject>Surgery</subject><subject>Surveys and Questionnaires</subject><issn>1057-9249</issn><issn>1099-1611</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><recordid>eNqNksFu1DAQhiMEomVB4gmQJS4cSIntTWwfUVVapFXLqhVws7zOeOuSdVLb6e72xJUn4z14EhwaFqkSgtNY42_-sWf-LHuOiwNcFORN17oDiil_kO3jQogcVxg_HM4lywWZir3sSQhXRZFgUT3O9gjhZUkJ2c--H92oplfRtg61BsVLQCqEVttdqvNtiCoC0spp8HnoQFtjNVJuYyFu0drGSxRg06sGmd7pofA1qqHzEMIgolw9FiO1XP7K3oBLAVmHVuAQ_vH12xaUR6ZtmnZt3RKF3i-tTorRg4oJiunSo6ZNOXsL9f1nPc0eGdUEeDbGSXbx7uji8CSfnR2_P3w7yzWtOM8Jx2QhCAHBocYVp8qwxaIAzkhVU1ZSYxZ1pTCvsdCKcCMApqoqAXRNsKKT7NWdbGp_3UOIcmWDhqZRDto-SDylBeaiwuw_UCwoZWJK_43SqhScFWlnk-zlPfSq7b1LXx4oxtKOGf8jqNOUggcjO29Xym8lLuTgGJkcIwfHJPTFKNgvVlDvwN8WSUB-B6xtA9u_CskPZ6ej4MjbEGGz45X_IiuWRiw_nR7L8_kcf_x8Ppcz-hODlt8M</recordid><startdate>201306</startdate><enddate>201306</enddate><creator>Tavlarides, Andrea M.</creator><creator>Ames, Steven C.</creator><creator>Diehl, Nancy N.</creator><creator>Joseph, Richard W.</creator><creator>Castle, Erik P.</creator><creator>Thiel, David D.</creator><creator>Broderick, Gregory A.</creator><creator>Parker, Alexander S.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QJ</scope><scope>ASE</scope><scope>FPQ</scope><scope>K6X</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>201306</creationdate><title>Evaluation of the association of prostate cancer-specific anxiety with sexual function, depression and cancer aggressiveness in men 1 year following surgical treatment for localized prostate cancer</title><author>Tavlarides, Andrea M. ; Ames, Steven C. ; Diehl, Nancy N. ; Joseph, Richard W. ; Castle, Erik P. ; Thiel, David D. ; Broderick, Gregory A. ; Parker, Alexander S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3688-2812b922e98ed1683af7bb0e8726d3753ffbd6a18d19ca28f9ee4a65eecd21a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Age Factors</topic><topic>Aged</topic><topic>Anxiety</topic><topic>Anxiety - diagnosis</topic><topic>Anxiety - etiology</topic><topic>Anxiety - psychology</topic><topic>Anxiety-Depression</topic><topic>Depression</topic><topic>Depression - diagnosis</topic><topic>Depression - etiology</topic><topic>Depression - psychology</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Male</topic><topic>Men</topic><topic>Middle Aged</topic><topic>oncology</topic><topic>Postoperative anxiety</topic><topic>Prospective Studies</topic><topic>Prostate cancer</topic><topic>Prostatectomy</topic><topic>Prostatic cancer</topic><topic>Prostatic Neoplasms - complications</topic><topic>Prostatic Neoplasms - psychology</topic><topic>Prostatic Neoplasms - surgery</topic><topic>Quality of Life</topic><topic>Severity of Illness Index</topic><topic>Sexual behavior</topic><topic>Sexual Dysfunction, Physiological - etiology</topic><topic>Sexual Dysfunctions, Psychological - etiology</topic><topic>Social psychology</topic><topic>Statistics, Nonparametric</topic><topic>Stress, Psychological</topic><topic>Surgery</topic><topic>Surveys and Questionnaires</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tavlarides, Andrea M.</creatorcontrib><creatorcontrib>Ames, Steven C.</creatorcontrib><creatorcontrib>Diehl, Nancy N.</creatorcontrib><creatorcontrib>Joseph, Richard W.</creatorcontrib><creatorcontrib>Castle, Erik P.</creatorcontrib><creatorcontrib>Thiel, David D.</creatorcontrib><creatorcontrib>Broderick, Gregory A.</creatorcontrib><creatorcontrib>Parker, Alexander S.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>British Nursing Index</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Psycho-oncology (Chichester, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tavlarides, Andrea M.</au><au>Ames, Steven C.</au><au>Diehl, Nancy N.</au><au>Joseph, Richard W.</au><au>Castle, Erik P.</au><au>Thiel, David D.</au><au>Broderick, Gregory A.</au><au>Parker, Alexander S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of the association of prostate cancer-specific anxiety with sexual function, depression and cancer aggressiveness in men 1 year following surgical treatment for localized prostate cancer</atitle><jtitle>Psycho-oncology (Chichester, England)</jtitle><addtitle>Psycho-Oncology</addtitle><date>2013-06</date><risdate>2013</risdate><volume>22</volume><issue>6</issue><spage>1328</spage><epage>1335</epage><pages>1328-1335</pages><issn>1057-9249</issn><eissn>1099-1611</eissn><coden>POJCEE</coden><abstract><![CDATA[Background
Cancer‐specific anxiety (CSA) can affect treatment decisions and is common in men following surgery for prostate cancer (PCa). We hypothesized that CSA is also associated with factors affecting quality of life. Herein, we examine the association of CSA with psychosocial factors and PCa aggressiveness in a cohort of men 1 year after prostatectomy for localized PCa.
Methods
From our prospective PCa Registry, we identified 365 men who underwent prostatectomy for localized PCa who completed the Memorial Anxiety Scale for Prostate Cancer (MAX‐PC) and Expanded Prostate Cancer Index Composite at 1‐year follow‐up. We evaluated the association of scores on the MAX‐PC with demographics, clinicopathologic features, sexual function, and depression scores using Wilcoxon Rank Sum and Kendall's tau correlation tests.
Results
Higher scores on the MAX‐PC (i.e., higher anxiety) are associated with younger age (p < 0.01) and non‐Caucasian race (p < 0.01). Men with higher MAX‐PC scores also reported poor sexual satisfaction/function (p < 0.01) and increasing depressive symptoms (p < 0.01). Finally, although higher anxiety is associated with several pathologic features of aggressiveness (stage, positive margins, PSA at 1 year; all p‐values < 0.01), we noted several men with clinically indolent disease who reported significant anxiety.
Conclusions
Our data suggest that higher levels of CSA are associated with poor sexual function and increased depressive symptoms 1 year after prostatectomy. Moreover, we noted demographic and pathologic features associated with higher CSA as well. If confirmed, our data support development of models to predict men at high risk of CSA following PCa surgery and targeted referral for additional counseling. Copyright © 2012 John Wiley & Sons, Ltd.]]></abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>22855322</pmid><doi>10.1002/pon.3138</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1057-9249 |
| ispartof | Psycho-oncology (Chichester, England), 2013-06, Vol.22 (6), p.1328-1335 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Applied Social Sciences Index & Abstracts (ASSIA) |
| subjects | Age Factors Aged Anxiety Anxiety - diagnosis Anxiety - etiology Anxiety - psychology Anxiety-Depression Depression Depression - diagnosis Depression - etiology Depression - psychology Follow-Up Studies Humans Male Men Middle Aged oncology Postoperative anxiety Prospective Studies Prostate cancer Prostatectomy Prostatic cancer Prostatic Neoplasms - complications Prostatic Neoplasms - psychology Prostatic Neoplasms - surgery Quality of Life Severity of Illness Index Sexual behavior Sexual Dysfunction, Physiological - etiology Sexual Dysfunctions, Psychological - etiology Social psychology Statistics, Nonparametric Stress, Psychological Surgery Surveys and Questionnaires |
| title | Evaluation of the association of prostate cancer-specific anxiety with sexual function, depression and cancer aggressiveness in men 1 year following surgical treatment for localized prostate cancer |
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