Amadori products promote cellular senescence activating insulin-like growth factor-1 receptor and down-regulating the antioxidant enzyme catalase

Activation of the insulin growth factor receptor-1 signaling pathways has been largely related to the aging process. Amadori products are produced in pathological conditions such as diabetes and aging, and are potentially involved in diabetic nephropathy or age-associated decline of renal function....

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Veröffentlicht in:	The international journal of biochemistry & cell biology 2013-07, Vol.45 (7), p.1255-1264
Hauptverfasser:	del Nogal-Ávila, María, Troyano-Suárez, Nuria, Román-García, Pablo, Cannata-Andía, Jorge B., Rodriguez-Puyol, Manuel, Rodriguez-Puyol, Diego, Kuro-O, Makoto, Ruiz-Torres, María P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation albumins Amadori product Amadori products antioxidants beta-galactosidase beta-Galactosidase - drug effects beta-Galactosidase - metabolism Catalase Catalase - biosynthesis cell cycle cell senescence Cells, Cultured Cellular senescence Cellular Senescence - physiology diabetic nephropathy Down-Regulation Glomerular Mesangium - cytology Glomerular Mesangium - metabolism Glycated albumin Humans insulin-like growth factor I Insulin-Like Growth Factor I - metabolism insulin-like growth factor I receptor Insulin-like growth factor-1 Mesangial Cells - metabolism Ras Receptor, IGF Type 1 - metabolism renal function rho GTP-Binding Proteins - biosynthesis Serum Albumin - pharmacology signal transduction Signal Transduction - drug effects Tumor Suppressor Protein p53 - biosynthesis
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