Sirtuin‐6–dependent genetic and epigenetic alterations are associated with poor clinical outcome in hepatocellular carcinoma patients

Sirtuin 6 (SIRT6) is a member of the sirtuin family of NAD+–dependent deacetylases. Genetic deletion of Sirt6 in mice results in a severe degenerative phenotype with impaired liver function and premature death. The role of SIRT6 in development and progression of hepatocellular carcinoma is currently...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2013-09, Vol.58 (3), p.1054-1064
Hauptverfasser:	Marquardt, Jens U., Fischer, Kerstin, Baus, Katharina, Kashyap, Anubha, Ma, Shengyun, Krupp, Markus, Linke, Matthias, Teufel, Andreas, Zechner, Ulrich, Strand, Dennis, Thorgeirsson, Snorri S., Galle, Peter R., Strand, Susanne
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Animals Apoptosis Carcinoma, Hepatocellular - diagnosis Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - physiopathology Cells, Cultured Disease Progression Down-Regulation - physiology Epigenesis, Genetic - physiology Epigenetics Female Gene expression Hepatology Humans Liver cancer Liver cirrhosis Liver Neoplasms - diagnosis Liver Neoplasms - genetics Liver Neoplasms - physiopathology Male Mice Mice, Knockout Middle Aged Oxidative Stress - physiology Prognosis Signal Transduction - physiology Sirtuins - genetics Sirtuins - physiology Survival Rate Tumors
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