Persimmon peel extract attenuates PDGF-BB-induced human aortic smooth muscle cell migration and invasion through inhibition of c-Src activity

•PPE inhibited PDGF-BB-induced migration and invasion in HASMCs.•PPE inhibited PDGF-BB induced MMP-1 expression in HASMCs.•PPE strongly inhibited Src kinase activity by direct binding.•PPE inhibited PDGF-BB induced MAPK and Akt signalling pathway.•PPE strongly inhibited PDGF-BB-induced rat aortic sp...

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Veröffentlicht in:	Food chemistry 2013-12, Vol.141 (4), p.3309-3316
Hauptverfasser:	Son, Joe Eun, Hwang, Mun Kyung, Lee, Eunjung, Seo, Sang Gwon, Kim, Jong-Eun, Jung, Sung Keun, Kim, Jong Rhan, Ahn, Gwang-Hwan, Lee, Ki Won, Lee, Hyong Joo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta - cytology Aorta - drug effects Aorta - metabolism Aortic smooth muscle cell Biological and medical sciences Cell Movement - drug effects Cells, Cultured Cellular Src Diospyros - chemistry Down-Regulation - drug effects Food toxicology Fruit - chemistry Humans Male Medical sciences Migration Myocytes, Smooth Muscle - cytology Myocytes, Smooth Muscle - drug effects Myocytes, Smooth Muscle - metabolism Persimmon extract Plant Extracts - pharmacology Platelet-derived growth factor Proto-Oncogene Proteins c-sis - metabolism Proto-Oncogene Proteins pp60(c-src) - antagonists & inhibitors Proto-Oncogene Proteins pp60(c-src) - genetics Proto-Oncogene Proteins pp60(c-src) - metabolism Rats Rats, Sprague-Dawley Toxicology
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