The combined effect of metformin and l-cysteine on inflammation, oxidative stress and insulin resistance in streptozotocin-induced type 2 diabetes in rats

Increasing evidence has established causative links between obesity, chronic inflammation and insulin resistance; the core pathophysiological feature in type 2 diabetes mellitus. This study was designed to examine whether the combination of l-cysteine and metformin would provide additional benefits...

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Veröffentlicht in:	European journal of pharmacology 2013-08, Vol.714 (1-3), p.448-455
Hauptverfasser:	Salman, Zenat K., Refaat, Rowaida, Selima, Eman, Sarha, Ashgan El, Ismail, Menna A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals blood glucose blood serum Body Weight - drug effects C-reactive protein C-Reactive Protein - metabolism Caspase 3 - metabolism caspase-3 Chemokine CCL2 - blood chemokines cysteine Cysteine - pharmacology Cysteine - therapeutic use cytochrome c Cytochromes c - metabolism Diabetes Mellitus, Experimental - blood Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - pathology Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - metabolism Diabetes Mellitus, Type 2 - pathology Drug Interactions fasting Fatty Acids, Nonesterified - blood free fatty acids glutathione Glutathione - metabolism glycemic effect high fat diet homeostasis inflammation Inflammation - drug therapy insulin Insulin Resistance l-Cysteine liver Liver - drug effects Liver - metabolism Liver - pathology Male malondialdehyde Malondialdehyde - metabolism Metformin Metformin - pharmacology Metformin - therapeutic use nitrates Nitrates - blood Nitrites - blood noninsulin-dependent diabetes mellitus obesity oxidative stress Oxidative Stress - drug effects Rats Rats, Wistar streptozotocin Streptozotocin-induced type 2 diabetes therapeutics
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