Association between first-trimester maternal serum pregnancy-associated plasma protein-A and obstetric complications

ABSTRACT Objective This study aimed to investigate the relationship between maternal serum pregnancy‐associated plasma protein‐A (PAPP‐A) in the first trimester of pregnancy and the development of preeclampsia (PE), early PE, small‐for‐gestational age (SGA) fetus and preterm delivery (PD). Method This is a retrospective study of 12 355 pregnant women that delivered between 2008 and 2011. We define the first, third and fifth percentiles of maternal serum PAPP‐A multiples of the median (MoM). The primary outcome measures were the occurrence of PE, early PE (PE requiring delivery before 34 weeks), SGA fetus (birth weight